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Publications from the Webb group


39. Mechanism of regulation of pantothenate biosynthesis by the PanD-PanZ.AcCoA complex reveals an additional mode of action for the antimetabolite N-pentyl pantothenamide (N5-Pan)
Zoe L.P. Arnott, Shingo Nozaki, Diana C.F. Monteiro, Holly E. Morgan, Arwen R. Pearson, Hironori Niki, Michael E. Webb Biochemistry (2017) in press

38. Affimers proteins are versatile and renewable affinity reagents
Christian Tiede, Robert Bedford, Sophie J. Heseltine, Gina Smith, Imeshi Wijetunga, Rebecca L. Ross, Danah Al-Qallaf, Ashley P. Roberts, Alexander Balls, Alistair Curd, Ruth E. Hughes, Heather Martin, Sarah R. Needham, Laura C. Zanetti-Domingues, Yasha Sadigh, Thomas P. Peacock, Anna A. Tang, Naomi Gibson, Hannah Kyle, Geoffrey W. Platt, Nicola Ingram, Thomas W. Taylor, Louise P. Coletta, Iain Manfield, Margaret A. Knowles, Sandra Bell, Filomena Esteves, Azhar Maqbool, Raj J. Prasad, Mark J. Drinkhill, Robin S. Bon, Vikesh Patel, Sarah A. Goodchild, Marisa L. Martin-Fernandez, Ray J. Owens, Joanne E. Nettleship, Michael E. Webb, Michael Harrison, Jonathan D. Lippiat, Sreenivasan Ponnambalam, Michelle Peckham, Alastair Smith, Paul Ko Ferrigno, Matt Johnson, Michael J. McPherson and Darren C. Tomlinson eLife (2017) 24903. See also: Press release

37. Double quick, double click reversible peptide "stapling"
Claire M. Grison, George M. Burslem, Jennifer A. Miles, Ludwig K.A. Pilsl, David J Yeo, Zeynab Imani, Stuart L. Warriner, Michael E. Webb, Andrew J. Wilson Chem. Sci. (2017) in press See also: press release

36. Protein surface mimetics: understanding how ruthenium tris(bipyridines) interact with proteins
Sarah H Hewitt, Maria H Filby, Ed Hayes, Lars T Kuhn, Arnout P. Kalverda, Michael E Webb and Andrew J Wilson ChemBioChem (2017) 18 223-231


35. The adsorption of fungal ice-nucleating proteins on mineral dusts: a terrestrial reservoir of atmospheric ice-nucleating particles
Daniel O'Sullivan, Benjamin J. Murray, James F. Ross, and Michael E. Webb Atmos. Chem. Phys. (2016) 16 7879-7887

34. Sortase-mediated labelling of lipid nanodiscs for cellular tracing
A. Ivona Petrache, Darren C. Machin, Daniel J. Williamson, Michael E. Webb and Paul A. Beales Mol. Bio. Syst. (2016) 12 1760-1763

33. Confirmation of a protein-protein interaction in the pantothenate biosynthetic pathway using Sortase-mediated labelling
Philip M.Morrison, Matthew R. Balmforth, Samuel W. Ness, Daniel J. Williamson, Michael D. Rugen, W. Bruce Turnbull and Michael E. Webb ChemBioChem (2016) 17 753-758


32. Chemical generation and modification of peptides containing multiple dehydroalanines
Phillip M. Morrison, Patrick J. Foley, Stuart L. Warriner & Michael E. Webb Chem. Commun. (2015) 51 13470-3

31. Strain-promoted reaction of 1,2,4-triazines with bicyclononynes
Katherine A. Horner, Nathalie M. Valette & Michael E. Webb Chem.—Eur. J. (2015) 21 14376-81

30. The Structure of the PanD/PanZ Protein Complex Reveals Negative Feedback Regulation of Pantothenate Biosynthesis by Coenzyme A
Diana C.F. Monteiro, Vijay Patel, Christopher P. Bartlett, Shingo Nozaki, Thomas D. Grant, James A. Gowdy, Gary S. Thompson, Arnout P. Kalverda, Edward H. Snell, Hironori Niki, Arwen R. Pearson & Michael E. Webb Chem. Biol. (2015) 22 492-503

29. The relevance of nanoscale biological fragments for ice nucleation in clouds
Daniel O'Sullivan, Benjamin J. Murray, James F. Ross, Tom F. Whale, Hannah C. Price, James D. Atkinson, Nsikanabasi S. Umo & Michael E Webb Sci. Rep. (2015) 5 8082


28. Evaluation of the interaction between phosphohistidine analogues and phosphotyrosine-binding domains
Tom E McAllister, Katherine A. Horner & Michael E Webb ChemBioChem (2014) 15 1088-1091

27. Threonine 57 is required for the post-translational activation of Escherichia coli aspartate alpha-decarboxylase
Michael E Webb, Briony A Yorke, Tom Kershaw, Sarah Lovelock, Carina M C Lobley, Mairi L Kilkenny, Alison G Smith, Tom L Blundell, Arwen R Pearson and Chris Abell Acta Cryst. (2014) D70 1176-1172

26. Depsipeptide substrates for sortase-mediated N-terminal protein ligation
D. J. Williamson, M. E. Webb & W. B. Turnbull Nat. Protoc. (2014) 9 253-262

25. Ice nucleation by soil dusts: relative importance of mineral dust and biogenic components
D. O'Sullivan, B. J. Murray, T. L. Malkin, T. Whale, N. S. Umo, J. D. Atkinson, H. C. Price, K. J. Baustian, J. Browse, and M. E. Webb Atmos. Chem. Phys. (2014) 4 1853-1867


24. Prospects for stable analogues of phosphohistidine
Tom E McAllister, Jeffrey J Hollins and Michael E Webb Biochem. Soc. Trans. (2013) 41 1072-1077


23. Ice nucleation by particles immersed in supercooled cloud droplets
Benjamin J Murray, Daniel O'Sullivan, James D Atkinson and Michael E Webb Chem. Soc. Rev. (2012) 41 6519-6554

22. Formation of a heterooctameric complex between ADC and its cognate activating factor, PanZ, is CoA-dependent
Diana C.F. Monteiro, Michael D Rugen, Dale Shepherd, Shingo Nozaki, Niki Hironori and Michael E Webb Biochem. Biophys. Res. Commun. (2012) 426 350-355

21. Efficient N-terminal labelling of proteins by use of Sortase
Daniel J. Williamson, Martin A. Fascione, Michael E Webb and W. Bruce Turnbull Angew. Chem. (2012) 51 9377-9380

20. An activator for pyruvoyl-dependent L-aspartate alpha-decarboxylase is conserved in a small group of the gamma-proteobacteria including Escherichia coli
Shingo Nozaki, Michael E Webb and Niki Hironori MicrobiologyOpen (2012) 1 298-300

19. Triazole phosphohistidine analogues compatible with the Fmoc-strategy
Tom E. McAllister and Michael E Webb. Org. Biomol. Chem. (2012) 10 4043-4049

18. Characterisation of the evolutionarily conserved iron sulphur cluster of sirohydrochlorin ferrochelatase from Arabidopsis thaliana
Kaushik Saha, Michael E Webb, Stephen EJ Rigby, Helen K Leech, Martin J Warren and Alison G Smith Biochem. J. (2012) 444 227-237

17. The crystal structure of Escherichia coli aspartate alpha-decarboxylase Asn72Ala: probing the role of Asn72 in pyruvoyl cofactor formation.
Michael E Webb, Carina M C Lobley, Fatima Soliman, Mairi L Kilkenny, Alison G Smith, Tom L Blundell and Chris Abell Acta Cryst.(2012) F68 414-417


16. Small-molecule ligands strongly affect the Förster resonance energy transfer between quantum dot and fluorescent protein
Yue Zhang, Haiyan Zhang, Jeff Hollins, Michael E. Webb and Dejian Zhou. Phys. Chem. Chem. Phys. (2011) 13 19427-19436

15. The pyruvate,orthophosphate dikinase regulatory proteins of Arabidopsis are both bifunctional and interact with the catalytic and nucleotide binding domains of pyruvate,orthophosphate dikinase
Holly M. Astley, Kate Parsley, Sylvain Aubry, Chris J. Chastain, Jim N. Burnell, Michael E. Webb and Julian M. Hibberd Plant J. (2011) 68 1070-1080

14. Pantothenate biosynthesis in higher plants
Michael E Webb and Alison G Smith. Adv. Botan. Res. (2011), 58, 203-255

13. Multilayer enzyme-coupled magnetic nanoparticles as efficient, reusable biocatalysts and biosensors.
Josep Garcia, Yue Zhang, Hannah Taylor, Oscar Cespedes, Michael E. Webb and Dejian Zhou. Nanoscale (2011) 3, 3721-3730

12. Fmoc-chemistry of stable analogues of phosphohistidine.
Tom E McAllister, Michael G Nix and Michael E Webb Chem. Commun. (2011) 47, 1297-1299


11. Oligobenzamide proteomimetic inhibitors of the p53-hDM2 protein-protein interaction.
Jeffrey P Plante, Thomas Burnley, Barbora Malkova, Michael E Webb, Stuart L Warriner, Thomas A Edwards and Andrew J Wilson Chem. Commun. (2009) 5091

Publications prior to 2007

10. Riboswitches regulate thiamine biosynthesis in the model green alga Chlamydomonas reinhardtii
Martin T Croft, Michael Moulin, Michael E Webb and Alison G Smith Proc. Natl. Acad. Sci. U. S. A. (2007) 104 20770-20775

 9. Plants need their vitamins too
Alison G. Smith, Martin T. Croft, Michael L. Moulin and Michael E. Webb Curr. Opin. Plant Biol. (2007) 10 266-275

8. Roles of vitamins B5, B9, B12 and molybdenum cofactor at cellular and organismal levels
F. Rébeillé, S. Ravanel. A. Marquet, R. R. Mendel, M.E. Webb, A. G. Smith and M. J. Warren Nat. Prod. Rep. (2007) 24 949-962

7. Elucidating biosynthesis pathways for vitamins and cofactors
M. E. Webb, A. Marquet, R. R. Mendel, F. Rébeillé and A. G. Smith Nat. Prod. Rep. (2007) 24 988-1088

6. Synthesis and biological evaluation of N-{4-[5-(2, 4-diamino-6-oxo-1, 6-dihydropyrimidin-5-yl)-2-(2, 2, 2-trifluoroacetyl) pentyl] benzoyl}-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway
Heng Cheng, Inkyu Hwang, Youhoon Chong, Ali Tavassoli, Michael E Webb, Yan Zhang, Ian A Wilson, Stephen J Benkovic, Dale L Boger Bioorg. Med. Chem. (2005) 13 2592-2599

5. Biosynthesis of pantothenate
Michael E. Webb, Alison G. Smith and Chris Abell Nat. Prod. Rep. (2004) 21 695-721

4. Structural constraints on protein self‐processing in L‐aspartate‐α‐decarboxylase
Florian Schmitzberger, Mairi L Kilkenny, Carina Lobley, Michael E Webb, Mladen Vinkovic, Dijana Matak‐Vinkovic, Michael Witty, Dimitri Y Chirgadze, Alison G Smith, Chris Abell, Tom L Blundell EMBO J. (2003) 22 6193-6204

3. Structural insights into the evolution of the pantothenate-biosynthesis pathway
CMC Lobley, F Schmitzberger, ML Kilkenny, H Whitney, HH Ottenhof, E Chakauya, ME Webb, LM Birch, KL Tuck, Chris Abell, AG Smith, TL Blundell Biochem. Soc. Trans. (2003) 31 563-572

2. Rapid screening by MALDI-TOF mass spectrometry to probe binding specificity at enzyme active sites
Michael E. Webb Elaine Stephens, Alison G. Smith and Chris Abell Chem. Commun. (2003) 2416-2417

1. Identification of Tyr58 as the proton donor in the aspartate-α-decarboxylase reaction
S Adrian Saldanha, Louise M Birch, Michael E Webb, Brent K Nabbs, Frank von Delft, Alison G Smith, Chris Abell Chem. Commun. (2001) 18 1760-1761