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Inaugural Dalton Symposium and Poster Prize

15 September 2015

The inaugural Dalton Younger Members Event (DYME@Leeds 2015) was held at the University of Leeds on 9-10th September.

This two-day conference saw national PhD and post-doctoral speakers from across the UK presenting their research in the area of inorganic chemistry.

PhD student, Jonathan Fowler from the Hardie and Willans groups at the University of Leeds, won the Dalton Transactions prize for the best poster contribution entitled "NHC Ligands in Metallo-supramolecular Chemistry: Fundamentals and Towards Carbene-Appended Cavitands".




The anticancer mechanism of a wasp venom peptide

7 September 2015

Research from the group of Dr Paul Beales has provided mechanistic insight into why a wasp venom peptide has anticancer properties.

The MP1 peptide, found in the venom of the aggressive Brazilian social wasp Polybia Paulista, is known to be able to inhibit the proliferation of, and in some cases kill, a variety of cancer cells without harming healthy cells such as red blood cells. However, until now, it was unclear why the peptide has these properties.

The natural role of this peptide is as an antibiotic, which attacks microbial membranes due to their different molecular composition compared to the wasp’s own cells. The team hypothesized that pathological changes in membrane composition were responsible for this peptide’s ability to specifically target cancer cells. It is known that PE and PS lipids, which are normally “hidden” on the inner leaflet of cell membranes become exposed to the outer membrane leaflet in many cancer cells.

In collaboration with Sao Paulo State University in Brazil and Dr Simon Connell in the School of Physics and Astronomy, this hypothesis was tested on model lipid membranes that were mainly composed of PC lipids (the major component of cell membranes) and containing neither, one of, or both PE and PS lipids. A variety of advanced biophysical spectroscopy and imaging techniques were applied to study the MP1 peptide’s interaction with these membranes. It was found that the PS lipid is required to increase the concentration of bound peptide on the membrane, whereas the PE lipid significantly increases the membrane’s susceptibility to disruption by the peptide. This facilitates the formation of large holes across the membrane that would allow vital biochemical constituents to leak from the cell and would lead to the loss of transmembrane chemical gradients. Therefore changes in the membrane composition of cancer cells form a mechanistic basis for the anticancer properties of MP1.

This work was recently published in Biophysical Journal and received significant international media attention. Coverage included the BBC website, BBC World Service, The International Business Times, The Times, The Guardian, The Independent, Phys.org, IFLscience, Discover Magazine, MTV and the Huffington Post.

This is early stage, fundamental research but these findings could in future aid the development of novel chemotherapies that target changes in the membrane composition of cancer cells. This would be a novel mechanism for an anticancer drug and so be particularly useful for the development of combination therapies where multiple drugs are used simultaneously to attack different parts of cancerous cells. The MP1 peptide has evolved as a natural antibiotic and not as an anticancer agent. Therefore it could be possible, now that there is insight into its mechanism of action, to improve the selectivity and potency of this peptide to cancer cells by designing modifications within its chemical structure.




Poster Prize

7 September 2015

Last week members of the McGowan and Willans groups travelled to St Anne’s College, Oxford for the RSC Coordination and Organometallic Chemistry Discussion Group meeting.

The two day event saw both national and international speakers presenting work in the areas of coordination and organometallic chemistry, with a poster session of around 100 posters. Heba Abdelgawad from the Willans group won first prize for her poster entitled ‘Silver N-Heterocyclic Carbene Complexes as Anticancer Agents’.




Vice Chancellor's Impact Award

4 September 2015

Professor Dwayne Heard has recently shared the University of Leeds Vice Chancellor’s Impact Award in the Engineering and Physical Sciences and Environment Sciences category for his group’s research in the African Monsoon Multidisciplinary Analysis (AMMA) project.

The lead investigator for this award is Professor Doug Parker from the School of Earth and Environment, together with Dr Jim McQuaid. AMMA is a very large project studying the impact of the West African Monsoon on the African and global environment. Dr Trevor Ingham from the School of Chemistry participated in a large field project in 2006, based in Niamey, Niger, to study details of the meteorology and chemistry of the West African Sahel, a region which separates the arid Sahara desert to the North from the wetter savannah and forests to the South. Measurements of the hydroxyl radical, which drives the chemical oxidative processing of natural and anthropogenic emissions, were made from the Facility for Airborne Atmospheric Measurements (FAAM), a highly instrumented aircraft operated by the NERC National Centre for Atmospheric Science and the Met Office.

Further details of the awards can be found at: http://www.leeds.ac.uk/forstaff/news/article/4865/outstanding_examples_of_leeds_research_impact_named




Chemical Communications Front Cover

23 July 2015

The 4 August 2015 issue of the flagship RSC journal Chemical Communications highlights a Feature Article by Dr James Henkelis (past PhD student at Leeds) and Prof Michaele Hardie on its front cover.

The article reviews the work of the Hardie group and other research groups around the world in constructing and controlling coordination cages based on cyclotriveratrylene-type ligands. Cyclotriveratrylene (CTV) is a bowl-shaped molecule which can act as a molecular host and bind guests in a non-covalent fashion.

The Hardie group at Leeds have a research programme developing ligand-functionalised CTVs which they use to self-assemble polyhedral cage-like architectures using transition metal binding.

The front cover picture shows the crystal structure of a capsule-like CTV-coordination cage after it has absorbed iodide guest molecules. The feature article, “Controlling the assembly of cyclotriveratrylene-derived coordination cages”,  is available on open access at http://pubs.rsc.org/en/content/articlelanding/2015/cc/c5cc03071d#!divAbstract




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