School of Chemistry

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1 March 2017
Time: 15:30 to 16:30
Location: Seminar Room 1.53g

Combining inorganic chemistry and polymer chemistry: towards nanomedicines and nanomaterials

Nicolas Barry, University of Bradford

Inorganic medicinal chemistry is in the early days of its development, although there are now a significant number of clinical trials involving metal compounds, or other agents which interfere with metabolic pathways, both for therapy and for diagnosis. However, a number of challenges in inorganic medicinal chemistry remain to be overcome, such as for example, tumour-targeting and reduction of side effects. Nanotechnology, which has been defined as the engineering and manufacturing of materials at the atomic and molecular scale, offers unique tools for developing safer and more effective medicines, and provides several potential advantages for drug formulation and delivery. In this presentation, we will discuss the design of metallated particles combining unusual ligands (carboranes), precious metals, and polymers, and their applications in medicinal chemistry.

Tailoring nanoscopic objects is also of importance for the production of materials of the future, for example in industrial manufacturing, construction, and space exploration. However, the direct observation of resolved single atoms, atom-by-atom crystal formation, and crystallization process is still an experimental frontier. We will discuss how, starting from the same metallated particles designed for biological applications, we developed a novel synthetic strategy for assembling, atom-by-atom, metal nanocrystals of defined size. Experimental insight into the dynamics of nanocrystals and pathways for their assembly from single atoms will be described, and the extent to which this technology can be generalised to a wide variety of metals and dopants will be discussed.