School of Chemistry

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Dejian Zhou

Senior Lecturer
Member of the Chemical Biology and Medicinal Chemistry group

Contact details

Room: 1.54
Tel: +44 (0)113 3436230
Email: D.Zhou@leeds.ac.uk

Keywords

Nanomaterials
Smart Nanoparticle Sensor
Drug Delivery
Single-Molecule Studies


Photograph of Dejian Zhou

Research interests

Materials on the nanometre scale (1-100 nm) have unique, sized-dependent optical and electrical properties that are distinct and unavailable from the bulk. We are interested in developing novel, functional nanomaterials and structures, investigating their unique properties and exploring their applications. Current group research activities include the following three themes:

Smart nanoparticle-aptamer sensors Aptamers are short artificial DNA or RNA oligonucleotides generated to bind a wide range of targets with high affinity and specificity. We are developing smart nanoparticle-aptamer sensing technology suitable for fast and sensitive detection of a wide range of targets, from toxic food residues, street drugs, environmental pollutants to disease biomarkers. We are also developing ultra-sensitive technologies capable of detecting sub fM (10-15M) concentrations of disease markers by combining smart nanoparticles and sensitive, single-molecule fluorescence readouts, which may allow earlier and faster diagnosis of some important diseases, such as cancer that are impossible for conventional methods (with Prof. Peter Stockley, FBS, Leeds).

Nanoparticle-bioconjugate devices. We are developing functional nanoparticle-bioconjugate devices, e.g. hybrid nanoparticle-DNA devices that maybe used as targeted drug delivery systems or local pH nanosensors which maybe useful for targeting cancer tumours (with Prof. Dongsheng Liu, Tsinghua, China). We are developing nanoparticle-polymer based targeted nanoscale drug delivery systems which could significantly enhance the therapeutic index and reducing the side-effects of chemotherapy (with Dr Rongjun Chen, Leeds). We are developing enzyme coupled nanoparticles as novel re-usable biosensors and studying the energy transfer between quantum dots and fluorescent proteins (with Dr Michael Webb, Leeds).

Single-molecule studies. The unique advantage of single-molecule (SM) method is that it can study individual SMs one at a time, avoiding ensemble average and complicated separation processes. We are using SM fluorescence resonance energy transfer (FRET) to probe the structural information and pathogen recognition of important viral receptors (with Prof. Kurt Drickamer, Imperial College). We are also investigating the folding/unfolding of G-quadruplex DNAs and their interactions with drugs and/or proteins using AFM force spectroscopy (with Prof. Kumar Sinniah, Kelvin College, USA)

Useful links

BBC News highlighted some of my work   
CV and publications   
   

Publications

Wang W, Guo Y, Tiede C, Chen S, Kopytynski M, Kong Y, Kulak A, Tomlinson D, Chen R, McPherson M, Zhou D Ultraefficient Cap-Exchange Protocol To Compact Biofunctional Quantum Dots for Sensitive Ratiometric Biosensing and Cell Imaging. ACS Appl Mater Interfaces -, 2017
DOI:10.1021/acsami.6b13807
View abstract

Wang W, Yang Y, Cheng E, Zhao M, Meng H, Liu D, Zhou D Correction: A pH-driven, reconfigurable DNA nanotriangle Chemical Communications 52 10696-10696, 2016
DOI:10.1039/C6CC90352E

Zhang W, Wang F, Wang Y, Wang J, Yu Y, Guo S, Chen R, Zhou D PH and near-infrared light dual-stimuli responsive drug delivery using DNA-conjugated gold nanorods for effective treatment of multidrug resistant cancer cells Journal of Controlled Release 232 9-19, 2016
DOI:10.1016/j.jconrel.2016.04.001
View abstract

Kong Y, Chen J, Fang H, Heath G, Wo Y, Wang W, Li Y, Guo Y, Evans SD, Chen S, Zhou D Highly Fluorescent Ribonuclease-A-Encapsulated Lead Sulfide Quantum Dots for Ultrasensitive Fluorescence in Vivo Imaging in the Second Near-Infrared Window Chemistry of Materials 28 3041-3050, 2016
DOI:10.1021/acs.chemmater.6b00208
View abstract

Guo Y, Sakonsinsiri C, Nehlmeier I, Fascione MA, Zhang H, Wang W, Pöhlmann S, Turnbull WB, Zhou D Compact, Polyvalent Mannose Quantum Dots as Sensitive, Ratiometric FRET Probes for Multivalent Protein-Ligand Interactions Angewandte Chemie 128 4816-4820, 2016
DOI:10.1002/ange.201600593
View abstract

Guo Y, Sakonsinsiri C, Nehlmeier I, Fascione MA, Zhang H, Wang W, Pöhlmann S, Turnbull WB, Zhou D Compact, Polyvalent Mannose Quantum Dots as Sensitive, Ratiometric FRET Probes for Multivalent Protein-Ligand Interactions Angewandte Chemie - International Edition 55 4738-4742, 2016
DOI:10.1002/anie.201600593
View abstract

Guo Y, Sakonsinsiri C, Nehlmeier I, Fascione MA, Zhang H, Wang W, Pöhlmann S, Turnbull WB, Zhou D Back Cover: Compact, Polyvalent Mannose Quantum Dots as Sensitive, Ratiometric FRET Probes for Multivalent Protein-Ligand Interactions (Angew. Chem. Int. Ed. 15/2016) Angewandte Chemie International Edition 55 4838-4838, 2016
DOI:10.1002/anie.201602014

Guo Y, Sakonsinsiri C, Nehlmeier I, Fascione MA, Zhang H, Wang W, Pöhlmann S, Turnbull WB, Zhou D Rücktitelbild: Compact, Polyvalent Mannose Quantum Dots as Sensitive, Ratiometric FRET Probes for Multivalent Protein-Ligand Interactions (Angew. Chem. 15/2016) Angewandte Chemie 128 4920-4920, 2016
DOI:10.1002/ange.201602014

Chen J, Kong Y, Wang W, Fang H, Wo Y, Zhou D, Wu Z, Li Y, Chen S Direct water-phase synthesis of lead sulfide quantum dots encapsulated byβ-lactoglobulin for in vivo second near infrared window imaging with reduced toxicity Chemical Communications 52 4025-4028, 2016
DOI:10.1039/c6cc00099a
View abstract

Wang J, Wang F, Li F, Zhang W, Shen Y, Zhou D, Guo S A multifunctional poly(curcumin) nanomedicine for dual-modal targeted delivery, intracellular responsive release, dual-drug treatment and imaging of multidrug resistant cancer cells Journal of Materials Chemistry B 4 2954-2962, 2016
DOI:10.1039/c5tb02450a
View abstract

Chen J, Kong Y, Wo Y, Fang H, Li Y, Zhang T, Dong Y, Ge Y, Wu Z, Zhou D, Chen S Facile synthesis ofβ-lactoglobulin capped Ag2S quantum dots for: In vivo imaging in the second near-infrared biological window Journal of Materials Chemistry B 4 6271-6278, 2016
DOI:10.1039/c6tb01186a
View abstract

Wang Y, Guo Y, Shen Y, Chen R, Wang F, Zhou D, Guo S HCl-Retarded gold nanorod growth for aspect ratio and shape tuning Journal of Nanoscience and Nanotechnology 16 1194-1201, 2016
DOI:10.1166/jnn.2016.10637
View abstract

Song L, Guo Y, Roebuck D, Chen C, Yang M, Yang Z, Sreedharan S, Glover C, Thomas J, Liu D, Guo S, Chen R, Zhou D Terminal PEGylated DNA-Gold Nanoparticle Conjugates Offering High Resistance to Nuclease Degradation and Efficient Intracellular Delivery of DNA Binding Agents ACS Applied Materials and Interfaces 7 18707-18716, 2015
DOI:10.1021/acsami.5b05228
View abstract

Tian W, Liu J, Guo Y, Shen Y, Zhou D, Guo S Self-assembled micelles of amphiphilic PEGylated rapamycin for loading paclitaxel and resisting multidrug resistant cancer cells Journal of Materials Chemistry B 3 1204-1207, 2015
DOI:10.1039/c4tb01633e
View abstract

Lapitan LDS, Guo Y, Zhou D Nano-enabled bioanalytical approaches to ultrasensitive detection of low abundance single nucleotide polymorphisms Analyst 140 3872-3887, 2015
DOI:10.1039/c4an02304h
View abstract

Lv L, Guo Y, Shen Y, Liu J, Zhang W, Zhou D, Guo S Intracellularly Degradable, Self-Assembled Amphiphilic Block Copolycurcumin Nanoparticles for Efficient In Vivo Cancer Chemotherapy Advanced Healthcare Materials 4 1496-1501, 2015
DOI:10.1002/adhm.201500075
View abstract

Wang F, Zhang W, Shen Y, Huang Q, Zhou D, Guo S Efficient RNA delivery by integrin-targeted glutathione responsive polyethyleneimine capped gold nanorods Acta Biomaterialia 23 136-146, 2015
DOI:10.1016/j.actbio.2015.05.028
View abstract

Wang F, Shen Y, Zhang W, Li M, Wang Y, Zhou D, Guo S Efficient, dual-stimuli responsive cytosolic gene delivery using a RGD modified disulfide-linked polyethylenimine functionalized gold nanorod Journal of Controlled Release 196 37-51, 2014
DOI:10.1016/j.jconrel.2014.09.026
View abstract

Zhang Y, Zhou D, He J FRET studies between CdTe capped by small-molecule ligands and fluorescent protein International Journal of Nanoscience 13 -, 2014
DOI:10.1142/S0219581X14600138
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Zhang Y, Zhou D, He J MicroRNA sensor based on magnetic beads and enzymatic probes International Journal of Nanoscience 13 -, 2014
DOI:10.1142/S0219581X1460014X
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Lv L, Shen Y, Liu J, Wang F, Li M, Li M, Guo A, Wang Y, Zhou D, Guo S Enhancing curcumin anticancer efficacy through di-block copolymer micelle encapsulation. Journal of biomedical nanotechnology 10 179-193, 2014
DOI:10.1166/jbn.2014.1809
View abstract

Lv L, Shen YY, Li M, Wang F, Li MN, Guo JJ, Wang Y, Zhou D, Guo S Enhancing Curcumin Anticancer Efficacy Through Di-Block Copolymer Micelle Encapsulation Journal of Biomedical Nanotechnology 10 179-193, 2014
DOI:10.1166/jbn.2014.1809
View abstract

Timmer CT, Michmerhuizen NL, Witte AB, Van Winkle M, Zhou D, Sinniah K An isothermal titration and differential scanning calorimetry study of the G-quadruplex DNA-insulin interaction J. Phys. Chem. B 118 1784-1790, 2014
DOI:10.1021/jp411293r
View abstract

Wang Y, Wang F, Guo Y, Chen R, Shen Y, Guo A, Liu J, Zhang X, Zhou D, Guo S Controlled synthesis of monodisperse gold nanorods with different aspect ratios in the presence of aromatic additives Journal of Nanoparticle Research 16 -, 2014
DOI:10.1007/s11051-014-2806-3
View abstract

Dobson P, Yung LL, Rossi L, Pikramenou Z, Carreira S, Ray P, Amiens C, Brown K, Abdollah M, Zhou D, Prato M, Moise S, Litti L, Todd M, Göeken K, Borsley S, Heuer-Jungemann A, Reiser O, Harvey P, Carter T, Thanou M, Soukup D, Lesniak A, Mattoussi H, Abdul Ghani SF Optical nanoparticles: General discussion Faraday Discussions 175 215-227, 2014
DOI:10.1039/C4FD90079K

Dobson P, Yung LL, Rossi L, Carreira S, Ray P, Amiens C, Brown K, Zhou D, Gavriilidis A, Thanh NTK, Moise S, Litti L, Mattoussi H, Todd M, Mitchell S, Borsley S, Heuer-Jungemann A, Reiser O, Tsang E, Thanou M, Berkleman T, Soukup D, Chester K, Parkin I, Diaz Fernandez YA, Burke BP Magnetic Nanoparticles: General discussion Faraday Discussions 175 113-125, 2014
DOI:10.1039/C4FD90078B

Zhang Y, Pilapong C, Guo Y, Ling Z, Cespedes O, Quirke P, Zhou D Sensitive, Simultaneous Quantitation of Two Unlabeled DNA Targets Using a Magnetic Nanoparticle-Enzyme Sandwich Assay Analytical Chemistry 85 9238-9244, 2013
DOI:10.1021/ac402081u
View abstract

Zhang HY, Feng GQ, Guo Y, Zhou D Robust, specific ratiometric biosensing using a copper-free clicked quantum dot-DNA aptamer sensor Nanoscale 5 10307-10315, 2013
DOI:10.1039/C3NR02897F
View abstract

Zhang Y, Guo Y, Quirke P, Zhou D Ultrasensitive single-nucleotide polymorphism detection using target-recycled ligation, strand displacement and enzymatic amplification Nanoscale 5 5027-5035, 2013
DOI:10.1039/C3NR01010D
View abstract

Song L, Ho VHB, Chen C, Yang Z, Liu D, Chen R, Zhou D Efficient, pH-triggered drug delivery using a pH-responsive DNA conjugated gold nanoparticle Advanced Healthcare Materials 2 275-280, 2013
DOI:10.1002/adhm.201200112
View abstract

Kong Y, Chen J, Gao F, Brydson R, Johnson B, Heath G, Zhang Y, Wu L, Zhou DJ Near-Infrared Fluorescent Ribonuclease-A-Encapsulated Gold Nanoclusters: Preparation, Characterization, Cancer Cell Targeting and Imaging Nanoscale 5 1009-1017, 2013
DOI:10.1039/C2NR32760K
View abstract

Derbyshire N, White SJ, Bunka DH, Song L, Stead S, Tarbin J, Sharman M, Zhou DJ, Stockley PG Toggled RNA Aptamers Against Aminoglycosides Allowing Facile Detection of Antibiotics Using Gold Nanoparticle Assays. Analytical Chemistry 84 6595-6602, 2012
DOI:10.1021/ac300815c
View abstract

Zhou DJ Quantum dot-nucleic acid/aptamer bioconjugate based fluorimetric biosensors Biochemical Society Transactions 40 635-639, 2012
DOI:10.1042/BST20120059
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Zhang Y, Zhou DJ Magnetic particle based ultrasensitive biosensors for diagnostics Expert Review of Molecular Diagnostics 12 565-571, 2012
DOI:10.1586/ERM.12.54
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Zhang HY, Zhou DJ A quantum dot-intercalating dye dual-donor FRET based biosensor Chemical Communications 48 5097-5099, 2012
DOI:10.1039/C2CC30422H
View abstract

Zhang Y, Zhang HY, Hollins J, Webb ME, Zhou DJ Small-molecule ligands strongly affect the Förster resonance energy transfer between quantum dot and fluorescent protein Physical Chemistry Chemical Physics 13 19427-19436, 2011
DOI:10.1039/c1cp22024a
View abstract

Garcia J, Zhang Y, Taylor H, Cespedes O, Webb WE, Zhou DJ Multilayer enzyme-coupled magnetic nanoparticles as efficient, reusable biocatalysts and biosensors Nanoscale 3 3721-3730, 2011
DOI:10.1039/C1NR10411J
View abstract

Zhou DJ, Li Y, Hall EA, Abell C, Klenerman D A chelating dendritic ligand capped quantum dot: preparation, surface passivation, bioconjugation and specific DNA detection Nanoscale 3 201-211, 2011
DOI:10.1039/C0NR00462F
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Zhang HY, Sockley PG, Zhou DJ Development of smart nanoparticle-aptamer sensing technology Faraday Discussions 149 319-332, 2011
DOI:10.1039/C005373B
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Bruckbauer A, Dunne PD, James P, Howes E, Jones R, Zhou DJ, Klenerman D Selective diffusion barriers separate membrane compartments Biophysical Journal 99 L01-L03, 2010
DOI:10.1016/j.bpj.2010.03.067
View abstract

Kim DC, Sohn JI, Zhou DJ, Duke TAJ, Kang DJ Controlled Assembly of Well-Defined 3D Bioarchitecture Using Two Active Enzymes ACS Nano 4 1580-1586, 2010
DOI:10.1021/nn900610u
View abstract

Batchelor M, Zhou DJ, Cooper MA, Abell C, Rayment T Vancomycin dimer formation between analogues of bacterial peptidoglycan surfaces probed by force spectroscopy Organic and Biomolecular Chemistry 8 1142-1148, 2010
DOI:10.1039/b919347b
View abstract

Lynch S, Battershell R, Scott J, Zhou D, Sinniah K A Single Molecule Force Spectroscopy Study of the Binding Interaction Between Insulin and G-Quadruplex DNA BIOPHYSICAL JOURNAL 98 592A-592A, 2010

Sinniah K, Lynch S, Baker H, Byker SG, Zhou D A Single Molecule Study of Guanine Quadruplex DNA BIOPHYSICAL JOURNAL 98 592A-592A, 2010

Cheng EJ, Xing YZ, Chen P, Yang Y, Sun YW, Zhou DJ, Xu LJ, Fan QH, Liu DS A pH-trigged, fast-responding DNA hydrogel Angewandte Chemie International Edition 48 7660-7663, 2009
DOI:10.1002/anie.200902538
View abstract

Lynch S, Baker H, Byker SG, Zhou DJ, Sinniah K Single Molecule Force Spectroscopy on G-Quadruplex DNA Chemistry - A European Journal 15 8113-8116, 2009
DOI:10.1002/chem.200901390
View abstract

Wang WX, Yang Y, Cheng EJ, Zhao MC, Meng HF, Liu DS, Zhou DJ A pH-driven, reconfigurable DNA nanotriangle Chemical Communications 2009 824-826, 2009
DOI:10.1039/b813064g
View abstract

Ndieyira JW, Watari M, Barrera AD, Zhou D, Vo¨gtli M, Batchelor M, Cooper MA, Strunz T, Horton MA, Abell C, Rayment T, Aeppli G, McKendry RA Nanomechanical detection of antibiotic– mucopeptide binding in a model for superbug drug resistance Nature Nanotechnology 3 691-696, 2008
DOI:10.1038/nnano.2008.275
View abstract

Zhou DJ, Ying LM, Hong X, Hall EA, Abell C, Klenerman D A Compact Functional Quantum Dot-DNA Conjugate: Preparation, Hybridization and Specific Label-free DNA Detection Langmuir 24 1659-1664, 2008
DOI:10.1021/la703583u
View abstract

Xu Y, Ye J, Liu HJ, Cheng EJ, Yang Y, Wang WX, Zhao MC, Zhou D, Liu DS, Fang RX DNA-templated CMV Viral Capsid Proteins Assembly Into Nanotubes Chemical Communications 49-51, 2008
DOI:10.1039/b715299j
View abstract

Wang WX, Liu HJ, Liu DS, Xu Y, Yang Y, Zhou DJ Use of the Inter-particle i-motif for the Controlled Assembly of Gold Nanoparticles Langmuir 23 11956-11959, 2007
DOI:10.1021/la702273a
View abstract

Kamper SG, Porter-Peden L, Blankespoor R, Sinniah K, Zhou DJ, Abell C, Rayment T Investigating the Specific Interactions between Carbonic Anhydrase and a Sulfonamide Inhibitor by Single Molecule Force Spectroscopy Langmuir 23 12561-12565, 2007
DOI:10.1021/la702148v

Bruckbauer A, James P, Zhou DJ, Yoon JW, Excell D, Korchev YE, Jones R, Klenerman D Nanopipet delivery of individual molecules to cellular compartments for single molecule fluorescence tracking Biophysical Journal 93 3120-3131, 2007
DOI:10.1529/biophysj.107.104737
View abstract

Clarke RW, Monnier N, Li HT, Zhou DJ, Browne H, Klenerman D Two-Color Fluorescence Analysis of Individual Virions Determines the Distribution of the Copy Number of Proteins in Herpes Simplex Virus Particles Biophysical Journal 93 1329-1337, 2007
DOI:10.1529/biophysj.107.106351
View abstract

Orlov A, Chan MC, Jefferson DA, Zhou D, Lynch RJ, Lambert RM Photocatalytic degradation of water-soluble organic pollutants on TiO2 modified with gold nanoparticles Environmental Technology 27 747-752, 2006
DOI:10.1080/09593332708618685
View abstract

Ying LM, Zhou DJ, Bruckbauer A Comment on Trapping Single Molecules by Dielectrophoresis Physical Review Letters 96 -, 2006
DOI:10.1103/PhysRevLett.96.199801

Li HT, Zhou DJ, Browne H, Klenerman D Evidence of Resonant Optical Trapping of Individual Fluorophore labeled Antibodies by Single-Molecule Fluorescence Spectroscopy Journal of the American Chemical Society 128 5711-5717, 2006
DOI:10.1021/ja056997t
View abstract

Rauf S, Zhou DJ, Abell C, Klenerman D, Kang DJ Building three-dimensional nanostructures with functional enzymes by surface templated layer-by-layer assembly Chemical Communications 1721-1723, 2006
DOI:10.1039/b517557g
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Geng JF, Li HW, Zhou DJ, Huck WTS, Johnson BFG A Dendrimer-based Co32 Nanocluster: Synthesis and Application as Catalyst in the Growth of Nearly Uniform-diameter Single-wall Carbon Nanotubes Polyhedron 25 585-590, 2006
DOI:10.1016/j.poly.2005.08.036
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Manzanera M, Frankel DJ, Li H, Zhou D, Bruckbauer A, Kreutzmann P, Blackburn JM, Abell C, Rayment T, Klenerman D, Barker PD Macroscopic 2D networks self-assembled from nanometer-sized protein/DNA complexes Nano Letters 6 365-370, 2006
DOI:10.1021/nl051599+
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Rodolfa KT, Bruckbauer A, Zhou DJ, Schevchuk AI, Korchev YE, Klenerman D Nanoscale pipetting for controlled chemistry in small arrayed water droplets using a double barrel pipet Nano Letters 6 252-257, 2006
DOI:10.1021/nl052215i
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Liu DS, Bruckbauer A, Abell C, Kang DJ, Balasubramanian S, Klenerman D, Zhou DJ A Reversible pH-Driven DNA Nanoswitch Array Journal of the American Chemical Society 128 2067-2071, 2006
DOI:10.1021/ja0568300
View abstract

Wang XZ, Zhou DJ, Sinniah K, Clarke C, Birch L, Li HT, Rayment T, Abell C Electrostatic Orientation of Enzymes on Surfaces for Ligand Screening Probed by Force Spectroscopy Langmuir 22 887-892, 2006
DOI:10.1021/la0525731
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Zhou DJ, Kang DJ Creating functional nanostructured materials at the crossroad of physics, chemistry and materials International Journal of Nanotechnology 2 440-468, 2005
DOI:10.1504/IJNT.2005.008078
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Rodolfa KT, Bruckbauer A, Zhou D, Korchev YE, Klenerman D Two-Component Graded Deposition of Biomolecules with a Double-Barrel Nanopipet Angewandte Chemie - International Edition 44 6854-6859, 2005
DOI:10.1002/anie.200502338

Ying LM, Bruckbauer A, Zhou DJ, Gorelik J, Schevchuk AI, Lab M, Korchev YE, Klenerman D The scanned nanopipette: a new tool for high resolution bioimaging and controlled deposition of biomolecules Physical Chemistry, Chemical Physics: a journal of European Chemical Societies 7 2859-2866, 2005
DOI:10.1039/b506743j
View abstract

Zhou DJ, Piper JD, Abell C, Klenerman D, Kang DJ, Ying LM Fluorescence Resonance Energy Transfer between a Quantum Dot Donor and a Dye Acceptor Attached to a DNA Chemical Communications 4807-4809, 2005
DOI:10.1039/b508911e
View abstract

Clarke RW, White SS, Zhou DJ, Ying LM, Klenerman D Trapping of Proteins in Physiological Buffer Using a Nanopipet Angewandte Chemie - International Edition 44 3737-3740, 2005
DOI:10.1002/anie.200500196

Zhou DJ, Bruckbauer A, Abell C, Klenerman D, Kang DJ Fabrication of Three-Dimensional Surface Structures with Highly Fluorescent Quantum Dots by Surface-Templated Layer-by-Layer Assembly Advanced Materials 17 1243-1248, 2005
DOI:10.1002/adma.200401520
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Zhou DJ, Bruckbauer A, Batchelor M, Kang DJ, Abell C, Klenerman D The Influence of the Foundation Layer on the Layer-by-layer Assembly of Poly-L-lysine and Polystyrenesulfonate and Its Usage in the Fabrication of 3D Microscale Features Langmuir 20 9089-9094, 2004
DOI:10.1021/la048619s
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Bruckbauer A, Zhou DJ, Ying LM, Abell C, Klenerman D A Simple Voltage Controlled Enzymatic Nanoreactor Produced in the Tip of a Nanopipet Nano Letters 4 1859-1862, 2004
DOI:10.1021/nl049029h
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Bruckbauer A, Zhou DJ, Kang DJ, Korchev YE, Abell C, Klenerman D An addressable antibody nanoarray made on a novel nanostructured surface Journal of the American Chemical Society 126 6508-6509, 2004
DOI:10.1021/ja0317426

Li HT, Zhou DJ, Browne H, Balasubraminian S, Klenerman D Molecule by molecule direct and quantitative counting of antibody-protein complexes in solution Analytical Chemistry 76 4446-4451, 2004
DOI:10.1021/ac049512c
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Zhou DJ, Wang XZ, Birch L, Rayment T, Abell C AFM Studies on Protein Immobilization on Charged Surfaces at the Nanoscale: Toward the Fabrication of Three-Dimensional Protein Nanostructures Langmuir 19 10557-10562, 2003
DOI:10.1021/la035491q
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Zhou D, Bruckbauer A, Ying LM, Abell C, Klenerman D Building three-dimensional surface biological assemblies at the nanometer scale Nano Letters 3 1517-1520, 2003
DOI:10.1021/nl0345926

Zhou DJ, Sinniah K, Abell C, Rayment T Label-free detection of DNA hybridization at the nanoscale: A highly sensitive and selective approach using atomic-force microscopy Angewandte Chemie - International Edition 42 4934-4937, 2003
DOI:10.1002/anie.200352178

Bruckbauer A, Zhou DJ, Ying LM, Korchev YE, Abell C, Klenerman D Multicomponent Submicron Features of Biomolecules Created by Voltage Controlled Deposition from A Nanopipet Journal of the American Chemical Society 125 9834-9839, 2003
DOI:10.1021/ja035755v
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Wang X, Zhou D, Rayment T, Abell C Systematic manipulation of surface chemical reaction on the nanoscale: A novel approach for constructing three-dimensional nanostructures Chemical Communications 9 474-475, 2003
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Wang XZ, Zhou DJ, Rayment T, Abell C Systematic manipulation of surfaces by sequential nanoscale chemical reactions: a novel approach for constructing three dimensional nanostructures Chemical Communications 9 474-475, 2003
DOI:10.1039/b211906d
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Zhou DJ, Sinniah K, Abell C, Rayment T Use of Atomic Force Microscopy for Making addresses of DNA coatings Langmuir 18 8749-8752, 2002
DOI:10.1021/la0258547
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Bruckbauer A, Ying LM, Rothery AM, Zhou DJ, Shevchuk AI, Abell C, Korchev YE, Klenerman D Writing with DNA and Protein Using a Nanopipet for Controlled Delivery Journal of the American Chemical Society 124 8810-8811, 2002
DOI:10.1021/ja026816c

Ashwell GJ, Paxton GAN, Whittam AJ, Tyrrel WD, Berry M, Zhou DJ Merocyanine dyes: self-assembled monolayers Journal of Materials Chemistry 12 1631-1635, 2002
DOI:10.1039/b110676g
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Ashwell GJ, Hamilton R, Wood BJ, Gentle IR, Zhou DJ Molecular Lego: non-centrosymmetric alignment within interdigitating layers Journal of Materials Chemistry 11 2966-2970, 2001
DOI:10.1039/B105657N
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Ashwell GJ, Zhou DJ, Hamilton R, Skjonnemand K, Green A Molecular Lego: Non-centrosymmetric Langmuir-Blodgett Films for Nonlinear Optical Applications Synthetic Metals 121 1455-1458, 2001
DOI:10.1016/S0379-6779(00)00779-7

Ashwell GJ, Zhou DJ, Skjonnemand K, Rajan R Second-Harmonic Generation from Alternate-Layer Langmuir-Blodgett Films of Optically Non-Linear Materials in which the Interleaving Species is a Complementary Dye or Poly(t-ButylMethacrylate)" Australian Journal of Chemistry 19-25, 2001
DOI:10.1071/CH00146
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Zhou D, Huang CH, Li FY Langmuir-Blodgett Films of Second-order Nonlinear Optical Materials In Ultrathin Films for Optics and Electronics , 2001

Ashwell GJ, Zhou D, Skjonnemand K Molecular engineering of non-centrosymmetric langmuir-blodgett films for NLO applications: Films with interlocking lego-type structures IEICE Transactions on Electronics E83-C 1057-1060, 2000
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Lang AD, Huang CH, Gan LB, Zhou D, Ashwell GJ Photoelectro-chemical properties of anilino squaraine derivatives in LB films Physical Chemistry, Chemical Physics: a journal of European Chemical Societies 1 2487-2490, 1999
DOI:10.1039/A900268E
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Ashwell GJ, Zhou DJ, Huang CH Z-type Langmuir-Blodgett Film of a Three Component Optically Nonlinear Dye Colloids and Surfaces A: Physicochemical and Engineering Aspects 155 47-50, 1999
DOI:10.1016/S0927-7757(98)00491-9
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Lang AD, Huang CH, Gan LB, Zhou DJ Studies of the photocurrent generation performance from a series of amphiphilic bis-chromorphore zinc complexes and correlation between photocurrent generation performance and molecular structure Synthetic Metals 99 97-103, 1999
DOI:10.1016/S0379-6779(98)01485-4
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Ashwell GJ, Zhou DJ, Skjonnemand K Z-type Films of A Two-legged Optically Nonlinear Dye Molecular Crystals and Liquid Crystals 337 413-416, 1999
DOI:10.1080/10587259908023465
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Li Q, Zhou DJ, Huang CH, Yao GQ, Zhou YF, Shigeo U, Masakazu M Synthesis, characterization and luminescence of Tb(III)-1-phenyl-3-methyl-4-acyl-5-pyrazolone ternary complexes Acta Chimica Sinica 56 56-57, 1998
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Zhao YL, Gan LB, Zhou DJ, Huang CH, Jiang JZ, Liu W Photocurrent generation from a self-assembling guest-host LB film of C-60(HOOC(C)under-barHNH(C)under-barHCOOH) and octopentyloxy phthalocyanine Solid State Communications 106 43-48, 1998
DOI:10.1016/S0038-1098(97)10243-5
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Lin Y, Zhang B, Xin YC, Guo CH, Dai L, Zhou DJ, Huang CH Observation of the disk mode pattern in organic microdisk Solid State Communications 105 445-447, 1998
DOI:10.1016/S0038-1098(97)10169-7

Lang AD, Zhai J, Huang CH, Gan LB, Zhao Y, Zhou DJ, Chen ZD Relationship between Structures and Photocurrent Generation Properties in A Series of Hemicyanine Congeners Journal of Physical Chemistry B 102 1424-1429, 1998
DOI:10.1021/jp972429r
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Zhao YL, Zhou DJ, Huang CH, Gan LB Langmuir-Blodgett Film of A Europium Complex and Its Application in A Silver Mirror Planar Microcavity Langmuir 14 417-422, 1998
DOI:10.1021/la971176q
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Li Q, Zhou DJ, Huang CH, Yao GQ, Zhou YF Synthesis, characterization and luminescence of Tb(III)-1-phenyl-3-methyl-4-acyl-5-pyrazolone ternary complexes Acta Chimica Sinica 56 52-57, 1998
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Luo CP, Gan LB, Zhou DJ, Huang CH Photoelectrochemical properties of a new C60 derivative: C60–glycine ester C60(C6H9NO4) Journal of the Chemical Society - Faraday Transactions 93 3115-3117, 1997
DOI:10.1039/A702057K
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Li Q, Zhou DJ, Huang CH, Yao GQ, Shigeo U, Masakazu M Synthesis and luminescence of a series terbium ternary complexes with 1-phenyl-3-methyl-4-acyl-5-pyrazolones Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities 18 -, 1997
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Zhou DJ, Ashwell GJ, Rajan R, Gan LB, Luo C, Huang CH The Synthesis, Langmuir Film Deposition and Optical Characterization of a 4-Acetalphenyl substitued C60-Pyrrolidine Derivative C60(C12H17NO2) Journal of the Chemical Society, Faraday Transactions 93 2077-2082, 1997
DOI:10.1039/A608570I
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Zhao YL, Zhou DJ, Yao GQ, Huang CH Strong Luminescent Tb(III)-Pyrazolone Complexes and Their Langmuir-Blodgett Films Langmuir 13 4060-4065, 1997
DOI:10.1021/la970009n
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Pavier MA, Richardson T, Searle TM, Huang CH, Li H, Zhou D Photoluminescence study of Langmuir-Blodgett films of a hemicyanine molecular complex containing Yb3+ Supramolecular Science 4 437-441, 1997
DOI:10.1016/S0968-5677(97)00043-6
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Zhou DJ, Li Q, Huang CH, Yao GQ, Umatani S, Matsui M, Ying LM, Yu AC, Zhao XS Room-temperature Fluorescence, Phosphorescence and Crystal Structure of Lanthide 4-Acyl Pyrazolone complexes: Ln(L)3.2H2O Polyhedron 16 1381-1389, 1997
DOI:10.1016/S0277-5387(96)00382-8
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Zhao YL, Gan LB, Zhou DJ, Luo CP, Huang CH, Jia GC, Wu T Synthesis of proline fullerene derivative Chinese Science Bulletin 42 1360-1363, 1997
DOI:10.1007/BF02882866

Zhou DJ, Gan LB, Luo CP, Huang CH, Wu Y A New 4-Acetalphenyl C60-pyrrolidine Derivative for Langmuir-Blodgett Study Solid State Communications 102 891-894, 1997
DOI:10.1016/S0038-1098(97)00116-6
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Zhou DJ, Zhao YL, Gan LB, Luo CP, Huang CH, Lu MJ, Pan JQ, Wu Y Synthesis of C-60-pyrrolidine derivatives by 1,3-dipolar cycloaddition of azomethine ylides to C-60 Chemical Journal of Chinese Universities 18 665-670, 1997
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Zhou DJ, Gan LB, Luo CP, Huang CH, Yao GQ The synthesis and fluorescence of a methoxy-phenyl substituted C-60-pyrrolidine derivative Chinese Journal of Chemistry 15 35-41, 1997
DOI:10.1002/cjoc.19970150108
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Xia WS, Huang CH, Zhou DJ Photoelectric Conversion from A Hemicyanine Dye Containing Zinc Complex in Langmuir-Blodgett Film Langmuir 13 80-84, 1997
DOI:10.1021/la960108l
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Zhou D, Huang CH Coordination Chemistry in Inorganic Rare Earth Complexes In Rare Earth Coordination Chemistry (in Chinese) , 1997

Zhou DJ, Ashwell GJ, Huang CH Improved Second Harmonic Generation from Langmuir-Blodgett Monolayers of an Ionically Combined Bis-chromophore Zinc Complex" Chemistry Letters 26 7-8, 1997

Zhou DJ, Huang CH, Luo CP, Yao GQ Synthesis, luminescent properties and Langmuir films of four new amphiphilic N-hexadecyl pyridinium tetrakis(3-phenyl-4-benzoyl-5-isoxazolone) lanthanide complexes Chemical Journal of Chinese Universities 17 1828-1832, 1996
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Li H, Huang C, Zhou D, Xu L, Li T, Zhao X, Xie X Synthesis, characterization and film formation properties of a novel diazol system containing rare earth complex of nonlinear optical material Progress in Natural Science 6 100-101, 1996
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Ying LM, Yu AC, Zhao XS, Li Q, Zhou DJ, Huang CH, Umetani S, Matasai M Excited State Properties and Intramolecular Energy Transfer of Rare-earth Acyl-pyrazolone Complexes Journal of Physical Chemistry 100 18387-18391, 1996
DOI:10.1021/jp960872g
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Luo CP, Huang CH, Gan LB, Zhou DJ, Xia WS, Zhuang QK, Zhao YL, Huang YY An Investigation of Photoelectrochemistry of C60 and Its Derivatives of C60-Pyrrolidine by Monolayer-Modified SnO2 Electrodes Journal of Physical Chemistry 100 16685-16689, 1996
DOI:10.1021/jp961428g
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Zhou DJ, Gan LB, Luo CP, Tan HS, Huang CH, Yao GQ, Zhang B Photoluminescence and Fluorescence Quenchings of C60-Pyrrolidine Derivatives at Room Temperature Journal of Photochemistry and Photobiology, A: Chemistry 99 37-43, 1996
DOI:10.1016/1010-6030(96)04386-9
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Pavier MA, Weaver MS, Lidzey D, Richardson T, Searle TM, Bradley DDC, Huang CH, Li H, Zhou D Electroluminescence from dysprosium- and neodymium-containing LB films Thin Solid Films 284-285 644-647, 1996
DOI:10.1016/S0040-6090(95)08411-8
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Li Q, Zhou DJ, Yao GQ, Huang CH Synthesis, fluorescence characteristics and Langmuir-Blodgett film of a green strongly fluorescent terbium-isobutyryl pyrazolone complex Chemical Journal of Chinese Universities 17 1016-1018, 1996
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Li H, Zhou DJ, Huang CH, Xu JM, Li TK, Xie XM, Zhao XS Langmuir-Blodgett Film and Second Harmonic Generation of A New Type Amiphiphilic Bis-chromophore Complex Dyes Journal of Chemical Society: Faraday Transactions 92 2585-2592, 1996
DOI:10.1039/FT9969202585
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Zhou DJ, Huang CH, Li H, Zhao XS, Yu AC Nonlinear Optical Bis-chromophore Zinc Complexes: Langmuir-Blodgett Film and Second Harmonic Generation Study Solid State Communications 99 739-744, 1996
DOI:10.1016/0038-1098(96)00190-1
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Gan LB, Zhou DJ, Luo CP, Tan HS, Huang CH, Lu MJ, Pan JQ, Wu Y Synthesis of Fullerene Aminoacid Derivatives by Direct Interaction of Aminoacid Ester with C60 The Journal of Organic Chemistry (Washington) 61 1954-1961, 1996
DOI:10.1021/jo951933u
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Zhou DJ, Gan LB, Luo CP, Tan HS, Huang CH, Yao GQ, Zhao XS, Liu ZF, Xia XH, Zhang B Langmuir-Blodgett Film and Photophysical Property of A C60-Sarcosine Methyl Ester Derivative Journal of Physical Chemistry 100 3150-3156, 1996
DOI:10.1021/jp951933y
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Zhou DJ, Huang CH, Yao GQ, Bai J, Li TK Luminescent Europium Dibenzoyl-methane Complexes and Their Langmuir-Blodgett Films Journal of Alloys and Compounds 235 156-162, 1996
DOI:10.1016/0925-8388(95)02159-0
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Li H, Huang CH, Zhou DJ, Xu LG, Li TK, Zhao XS, Xie XM Synthesis, characterization and film formation properties of a novel diazol system containing rare earth complex of nonlinear optical material Progress in Natural Science 6 96-101, 1996
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Zhang B, Zhuang L, Lin Y, Xia ZJ, Ma Y, Ding XM, Wang SM, Zhou DJ, Huang CH Microcavity of organic semiconductor Solid State Communications 97 445-449, 1996
DOI:10.1016/0038-1098(95)00705-9
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Weaver MS, Lidzey DG, Pavier MA, Mellor H, Thorpe SL, Bradley DDC, Richardson T, Searle TM, Huang CH, Li H, Zhou D Organic light-emitting diodes (LEDs) based on Langmuir-Blodgett films containing rare-earth complexes Syntehtic metals 76 91-93, 1996
DOI:10.1016/0379-6779(95)03425-J
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Zhou DJ, Tan HS, Gan LB, Luo CP, Huang CH, Pan JQ, Lu MJ, Wu Y Fullerene Induced C-N Bond Breaking and Formation: Synthesis of Fullerene Pyrrolidine and Methanofullerene Sarcosine Derivatives by Photochemical Addition of Sarcosine Ester to C60 Tetrahedron Letters 36 9169-9172, 1995
DOI:10.1016/0040-4039(95)02036-O
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Zhou DJ, Gan LB, Tan HS, Luo CP, Huang CH, Pan JQ, Lu MJ, Wu Y Synthesis of fullerene pyrrolidines containing substituted phenyl groups through azomethine ylide addition Chinese Chemical Letters 6 1033-1036, 1995
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Zhou DJ, Gan LB, Tan HS, Luo CP, Yao GQ, Huang CH Room-temperature fluorescence of C-60-glycine ester derivatives in solution Chemical Journal of Chinese Universities 16 1512-1513, 1995
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Zhou DJ, Yao GQ, Huang CH, Bai J, Li TK Langmuir-Blodgett film of strong luminescent europium-dibenzoylmethane complexes Chinese Chemical Letters 6 903-906, 1995
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Zhou DJ, Gan LB, Tan HS, Luo CP, Yao GQ, Huang CH, Zhang B Room-Temperature Fluorescence of C60-Sarcosine Ester Derivatives in Solution Chinese Science Bulletin 40 2053-2056, 1995

Zhou DJ, Tan HS, Gan LB, Luo CP, Huang CH, Yao GQ Room-Temperature Photoluminescence of A C60 Derivative Chemistry Letters 649-650, 1995

Zhou DJ, Gan LB, Luo CP, Tan HS, Huang CH, Liu ZF, Wu Z, Zhao XS, Xia XH, Zhang S, Sun FQ, Xia ZJ, Zou YH Langmuir-Blodgett Film and Nonlinear Optical Property of C60-Glycine Ester Derivatives Chemical Physics Letters 235 548-551, 1995
DOI:10.1016/0009-2614(95)00097-N
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Gan LB, Zhou DJ, Luo CP, Huang CH, Pan JQ, Lu MJ, Wu Y Reaction of C-60 and 2-amino-ethylhydrogensulfate Chinese Chemical Letters 6 199-200, 1995
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Wang KZ, Huang CH, Zhou DJ, Xu GX, Xu Y, Liu YQ, Zhu DB, Zhao XS, Xie XM Second-order nonlinear optical property of Langmuir-Blodgett film prepared from a novel ferrocenyl-containing lanthanide complex Solid State Communications 93 189-191, 1995
DOI:10.1016/0038-1098(94)00765-9
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Zhou DJ, Gan LB, Xu LB, Luo CP, Huang CH Glycine c6o adduct and its rare earth complexes Fullerene Science and Technology 3 127-131, 1995
DOI:10.1080/153638X9508543775
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Zhou DJ, Wang KZ, Huang CH, Xu GX, Xu LG, Li TK Langmuir-Blodgett Film Study on N-Hexadecyl Pyridinium Tetrakis(b-Naphthyltrifluoroacetone) Europium, HDP.Eu(NTA)4 Solid State Communications 93 167-169, 1995
DOI:10.1016/0038-1098(94)00659-8
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Gan LB, Zhou DJ, Luo CP, Huang CH, Li TK, Bai J, Zhao XS, Xia XH Langmuir-Blodgett Film and Second Harmonic Generation of C60(C4H8N2) Journal of Physical Chemistry 98 12459-12461, 1994
DOI:10.1021/j100099a001

Huang CH, Gan LB, Luo CP, Zhou DJ, Xu GX, Sun YL, Xiong Y, Gu ZN, Zhou XH A NOVEL CHEMICAL METHOD FOR PREPARATION OF 99-PERCENT PURE C60 Chinese Science Bulletin 39 1706-1708, 1994

Zhou DJ, Huang CH, Wang KZ, Xu GX Synthesis, Characterization Crystal Structure and Luminescent Property Study on a Novel Heteronuclear Rare Earth Complex, {H[EuLa2(DPA)5.8H2O].8H2O}n, H2DPA=Pyridine-2,6-Dicarboxylic Acid Polyhedron 13 987-991, 1994
DOI:10.1016/S0277-5387(00)83020-X
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Zhou DJ, Huang CH, Wang KZ, Xu GX, Zhao XS, Xie XM, Xu LG, Li TK Langmuir-Blodgett Film and Second Harmonic Generation of a Europium Hemicyanine Complex: Me₂NC₆H₄CH=CHC₅H₄NC₁₆H₃₃⁺Eu(NTA)₄⁻ Langmuir 10 1910-1912, 1994
DOI:10.1021/la00018a049
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Guo Y, Nehlmeier I, Poole E, Sakonsinsiri C, Hondow N, Brown A, Li Q, Li S, Whitworth J, Li Z, Yu A, Brydson R, Turnbull WB, Pöhlmann S, Zhou D Dissecting multivalent receptor-carbohydrate recognition and blocking Ebola virus infection using polyvalent multifunctional glycan-quantum dots Nature Communications -,
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Guo Y, Turnbull WB, Zhou D Probing Multivalent Protein-Carbohydrate Interactions By Quantum Dot-Förster Resonance Energy Transfer,
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