School of Chemistry

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Andrew Wilson

Professor of Organic Chemistry
Member of the Chemical Biology and Medicinal Chemistry group

Contact details

Room: G15
Tel: +44 (0)113 3431409
Email: A.J.Wilson@leeds.ac.uk

Keywords

Synthetic chemistry
Molecular recognition and self-assembly
Chemical Biology
Supramolecular Materials


Photograph of Andrew Wilson

Research interests

Our group is interested in using synthetic molecules to solve problems in Chemical Biology and Materials Science. The major theme of our multidisciplinary program involves the development and application of robust methods for synthesis of designed compounds. These compounds are used as tools to study molecular recognition and self-assembly using modern characterisation techniques. Current areas of interest include: the development of inhibitors of protein-protein interactions - a novel target class for pharmaceutical intervention, structural and mechanistic studies of amyloid assembly and development of supramolecular polymers based on novel hydrogen-bonding motifs.

Useful links

Wilson Group Pages   
   
   

Publications

Burslem GM, Kyle HF, Breeze AL, Edwards TA, Nelson A, Warriner SL, Wilson AJ Towards "bionic" proteins: Replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics Chemical Communications 52 5421-5424, 2016
DOI:10.1039/c6cc01812b
View abstract

Wilson AJ, Gunning PT Understanding Protein-Protein Interactions: Essential Players in (Patho)physiology (Part 2) ChemMedChem 11 732-733, 2016
DOI:10.1002/cmdc.201600158
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Azzarito V, Rowell P, Barnard A, Edwards TA, Macdonald A, Warriner SL, Wilson AJ Probing Protein Surfaces: QSAR Analysis with Helix Mimetics ChemBioChem 17 768-773, 2016
DOI:10.1002/cbic.201500504
View abstract

Wilson AJ, Gunning PT Understanding Protein-Protein Interactions: Essential Players in (Patho)physiology (Part 1). Chembiochem : a European journal of chemical biology 17 644-645, 2016
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Liu LJ, He B, Miles JA, Wang W, Mao Z, Che WI, Lu JJ, Chen XP, Wilson AJ, Ma DL, Leung CH Inhibition of the p53/hDM2 protein-protein interaction by cyclometallated iridium(III) compounds. Oncotarget 7 13965-13975, 2016
View abstract

Burslem GM, Kyle HF, Prabhakaran P, Breeze AL, Edwards TA, Warriner SL, Nelson A, Wilson AJ Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups Organic and Biomolecular Chemistry 14 3782-3786, 2016
DOI:10.1039/c6ob00078a
View abstract

Rodriguez-Marin S, Murphy NS, Shepherd HJ, Wilson AJ Design, synthesis and conformational analyses of bifacial benzamide based foldamers RSC Advances 5 104187-104192, 2015
DOI:10.1039/c5ra20451h
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Wilson AJ Helix mimetics: Recent developments PROGRESS IN BIOPHYSICS&MOLECULAR BIOLOGY 119 33-40, 2015
DOI:10.1016/j.pbiomolbio.2015.05.001

Kyle HF, Wickson KF, Stott J, Burslem GM, Breeze AL, Tiede C, Tomlinson DC, Warriner SL, Nelson A, Wilson AJ, Edwards TA Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies Molecular BioSystems 11 2738-2749, 2015
DOI:10.1039/c5mb00284b
View abstract

Azzarito V, Miles JA, Fisher J, Edwards TA, Warriner SL, Wilson AJ Stereocontrolled protein surface recognition using chiral oligoamide proteomimetic foldamers Chemical Science 6 2434-2443, 2015
DOI:10.1039/c4sc03559c
View abstract

Houton KA, Burslem GM, Wilson AJ Development of solvent-free synthesis of hydrogen-bonded supramolecular polyurethanes Chemical Science 6 2382-2388, 2015
DOI:10.1039/c4sc03804e
View abstract

Barnard A, Long K, Martin HL, Miles JA, Edwards TA, Tomlinson DC, Macdonald A, Wilson AJ Selective and potent proteomimetic inhibitors of intracellular protein-protein interactions Angewandte Chemie - International Edition 54 2960-2965, 2015
DOI:10.1002/anie.201410810
View abstract

Barnard A, Long K, Martin HL, Miles JA, Edwards TA, Tomlinson DC, Macdonald A, Wilson AJ Selective and Potent Proteomimetic Inhibitors of Intracellular Protein-Protein Interactions. Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 127 3003-3008, 2015
View abstract

Wilson AJ Helix mimetics: Recent developments Progress in Biophysics and Molecular Biology 119 33-40, 2015
DOI:10.1016/j.pbiomolbio.2015.05.001
View abstract

Barnard A, Miles JA, Burslem GM, Barker AM, Wilson AJ Multivalent helix mimetics for PPI-inhibition. Organic and Biomolecular Chemistry 13 258-264, 2015
DOI:10.1039/c4ob02066a
View abstract

Houton KA, Wilson AJ Hydrogen-bonded supramolecular polyurethanes Polymer International 64 165-173, 2015
DOI:10.1002/pi.4837
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Barnard A, Long K, Yeo DJ, Miles JA, Azzarito V, Burslem GM, Prabhakaran P, Edwards TA, Wilson AJ Orthogonal functionalisation ofα-helix mimetics. Organic and Biomolecular Chemistry 12 6794-6799, 2014
DOI:10.1039/c4ob00915k
View abstract

Burslem GM, Kyle HF, Breeze AL, Edwards TA, Nelson A, Warriner SL, Wilson AJ Small-molecule proteomimetic inhibitors of the HIF-1α-p300 protein-protein interaction. ChemBioChem 15 1083-1087, 2014
DOI:10.1002/cbic.201400009
View abstract

Preston GW, Radford SE, Ashcroft AE, Wilson AJ Analysis of amyloid nanostructures using photo-cross-linking: in situ comparison of three widely used photo-cross-linkers. ACS Chem Biol 9 761-768, 2014
DOI:10.1021/cb400731s
View abstract

Burslem GM, Wilson AJ Synthesis of oligobenzamideα-Helix Mimetics Synlett 25 324-335, 2014
DOI:10.1055/s-0033-1340342
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Gooch A, Murphy NS, Thomson NH, Wilson AJ Side-Chain Supramolecular Polymers Employing Conformer Independent Triple Hydrogen Bonding Arrays MACROMOLECULES 46 9634-9641, 2013
DOI:10.1021/ma402069b

Yeo DJ, Warriner SL, Wilson AJ Monosubstituted alkenyl amino acids for peptide "stapling". Chemical Communications 49 9131-9133, 2013
DOI:10.1039/c3cc45231j
View abstract

Thompson S, Wilson AJ, Battersby AR In celebration of the 60th birthday of Professor Andrew D. Hamilton FRS ORGANIC&BIOMOLECULAR CHEMISTRY 11 6236-6241, 2013
DOI:10.1039/c3ob90109b

Wilson AJ Synthesis of peptidomimetic scaffolds In Understanding and Exploiting Protein-Protein Interactions as Drug Targets , 2013
DOI:10.4155/EBO.13.176

Long K, Edwards TA, Wilson AJ Microwave assisted solid phase synthesis of highly functionalized N-alkylated oligobenzamideα-helix mimetics. Bioorg Med Chem 21 4034-4040, 2013
DOI:10.1016/j.bmc.2012.09.053
View abstract

Murphy NS, Prabhakaran P, Azzarito V, Plante JP, Hardie MJ, Kilner CA, Warriner SL, Wilson AJ Solid-phase methodology for synthesis of O-alkylated aromatic oligoamide inhibitors ofα-helix-mediated protein-protein interactions. Chemistry - A Eupoean Journal 19 5546-5550, 2013
DOI:10.1002/chem.201204098
View abstract

Preston GW, Wilson AJ Photo-induced covalent cross-linking for the analysis of biomolecular interactions. Chem Soc Rev 42 3289-3301, 2013
DOI:10.1039/c3cs35459h
View abstract

Wilson AJ, Ault JR, Filby MH, Philips HI, Ashcroft AE, Fletcher NC Protein destabilisation by ruthenium(II) tris-bipyridine based protein-surface mimetics. Org Biomol Chem 11 2206-2212, 2013
DOI:10.1039/c3ob26251k
View abstract

Azzarito V, Warriner SL, Wilson AJ Oligobenzamide alpha-helix mimetic scaffolds: The role of non-covalent interactions in molecular recognition, 2013

Pellizzaro ML, Fisher J, Wilson AJ Electronic substituent effects on hydrogen-bonding motifs modulate supramolecular polymerisation RSC Advances 3 3103-3108, 2013
DOI:10.1039/c2ra22715k
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Azzarito V, Long K, Murphy NS, Wilson AJ Inhibition ofα-helix-mediated protein-protein interactions using designed molecules. Nat Chem 5 161-173, 2013
DOI:10.1038/nchem.1568
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Pellizzaro ML, Houton KA, Wilson AJ Sequential and phototriggered supramolecular self-sorting cascades using hydrogen-bonded motifs Chemical Science 1825-1829, 2013
DOI:10.1039/c3sc22194f
View abstract

Prabhakaran P, Barnard A, Murphy NS, Wilson AJ, Kilner CA, Edwards TA Aromatic Oligoamide Foldamers with a "Wet Edge" as Inhibitors of theα-Helix-Mediated p53-hDM2 Protein-Protein Interaction European Journal of Organic Chemistry -, 2013
DOI:10.1002/ejoc.201300069
View abstract

Phillips HIA, Chernikov AV, Fletcher NC, Ashcroft AE, Ault JR, Filby MH, Wilson AJ The use of electrospray mass spectrometry to determine speciation in a dynamic combinatorial library for anion recognition Chemistry - A European Journal 18 13733-13742, 2012
DOI:10.1002/chem.201201302
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Azzarito V, Prabhakaran P, Bartlett AI, Murphy NS, Hardie MJ, Kilner CA, Edwards TA, Warriner SL, Wilson AJ 2-O-alkylated para-benzamideα-helix mimetics: the role of scaffold curvature. Org Biomol Chem 10 6469-6472, 2012
DOI:10.1039/c2ob26262b
View abstract

Fuller J, Jackson R, Edwards TA, Wilson AJ, Shirts MR Modeling of arylamide helix mimetics in the p53 peptide binding site of hDM2 suggests parallel and anti-parallel conformations are both stable. PLoS One 7 -, 2012
DOI:10.1371/journal.pone.0043253
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Preston GW, Radford SE, Ashcroft AE, Wilson AJ Covalent cross-linking within supramolecular peptide structures. Anal Chem 84 6790-6797, 2012
DOI:10.1021/ac301198c
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Pellizzaro ML, Barrett SA, Fisher J, Wilson AJ Design, synthesis and binding studies of a novel quadruple ADDA hydrogen-bond array. Org Biomol Chem 10 4899-4906, 2012
DOI:10.1039/c2ob25333j
View abstract

Gooch A, Nedolisa C, Houton KA, Lindsay CI, Saiani A, Wilson AJ Tunable self-assembled elastomers using triply hydrogen-bonded arrays Macromolecules 45 4723-4729, 2012
DOI:10.1021/ma3001109
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Prabhakaran P, Azzarito V, Jacobs T, Hardie MJ, Kilner CA, Edwards TA, Warriner SL, Wilson AJ Conformational properties of O-alkylated benzamides Tetrahedron 68 4485-4491, 2012
DOI:10.1016/j.tet.2011.11.078
View abstract

Turrell SJ, Filby MH, Whitehouse A, Wilson AJ Cellular uptake of highly-functionalized ruthenium(II) tris-bipyridine protein-surface mimetics. Bioorg Med Chem Lett 22 985-988, 2012
DOI:10.1016/j.bmcl.2011.12.007
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Pellizzaro ML, McGhee AM, Renton LC, Nix MG, Fisher J, Turnbull WB, Wilson AJ Conformer-independent ureidoimidazole motifs--tools to probe conformational and tautomeric effects on the molecular recognition of triply hydrogen-bonded heterodimers. Chemistry 17 14508-14517, 2011
DOI:10.1002/chem.201102128
View abstract

Gooch A, Barrett S, Fisher J, Lindsay CI, Wilson AJ Ditopic triply hydrogen-bonded heterodimers. Org Biomol Chem 9 5938-5940, 2011
DOI:10.1039/c1ob05593c
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Edwards TA, Wilson AJ Helix-mediated protein--protein interactions as targets for intervention using foldamers. Amino Acids 41 743-754, 2011
DOI:10.1007/s00726-011-0880-8
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Wilson AJ Hydrogen bonding: Attractive arrays. Nat Chem 3 193-194, 2011
DOI:10.1038/nchem.996

Gooch A, McGhee AM, Pellizzaro ML, Lindsay CI, Wilson AJ Substituent control over dimerization affinity of triply hydrogen bonded heterodimers. Org Lett 13 240-243, 2011
DOI:10.1021/ol102619u
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McGhee AM, Plante JP, Kilner CA, Wilson AJ Solid-state structures of ureidoimidazoles Supramol Chem 23 470-479, 2011
DOI:10.1080/10610278.2010.550289
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Filby MH, Muldoon J, Dabb S, Fletcher NC, Ashcroft AE, Wilson AJ Protein surface recognition using geometrically pure Ru(II) tris(bipyridine) derivatives Chemical Communications 47 559-561, 2011
DOI:10.1039/C0CC04754F

Campbell F, Plante JP, Edwards TA, Warriner SL, Wilson AJ N-alkylated oligoamide alpha-helical proteomimetics. Org Biomol Chem 8 2344-2351, 2010
DOI:10.1039/c001164a
View abstract

Campbell F, Kilner CA, Wilson AJ Expedient synthesis of benzene tricarboxamide macrocycles derived from p-aminobenzoic acid TETRAHEDRON LETT 51 1361-1363, 2010
DOI:10.1016/j.tetlet.2009.12.137

Muldoon J, Ashcroft AE, Wilson AJ Selective protein-surface sensing using ruthenium(II) tris(bipyridine) complexes. Chemistry 16 100-103, 2010
DOI:10.1002/chem.200902368

Wilson AJ Nanonose for sniffing out proteins NAT CHEM 1 429-430, 2009
DOI:10.1038/nchem.343

Campbell F, Wilson AJ An 'impossible' macrocyclisation using conformation directing protecting groups TETRAHEDRON LETT 50 2236-2238, 2009
DOI:10.1016/j.tetlet.2009.02.186

Wilson AJ Inhibition of protein-protein interactions using designed molecules CHEM SOC REV 38 3289-3300, 2009
DOI:10.1039/b807197g

Wilson AJ Inhibition of protein-protein interactions using designed molecules CHEM SOC REV 38 3289-3300, 2009
DOI:10.1039/b807197g

Gooch A, McGhee AM, Renton LC, Plante JP, Lindsay CI, Wilson AJ Design, synthesis and binding properties of conformer-independent linear ADA hydrogen-bonding arrays, 2009
DOI:10.1080/10610270802468397

Plante JP, Burnley T, Malkova B, Webb ME, Warriner SL, Edwards TA, Wilson AJ Oligobenzamide proteomimetic inhibitors of the p53-hDM2 protein-protein interaction CHEM COMMUN 5091-5093, 2009
DOI:10.1039/b908207g

Smith DP, Anderson J, Plante J, Ashcroft AE, Radford SE, Wilson AJ, Parker MJ Trifluoromethyldiazirine: an effective photo-induced cross-linking probe for exploring amyloid formation. Chem Commun (Camb) 5728-5730, 2008
DOI:10.1039/b813504e
View abstract

Plante J, Campbell F, Malkova B, Kilner C, Warriner SL, Wilson AJ Synthesis of functionalised aromatic oligamide rods. Org Biomol Chem 6 138-146, 2008
DOI:10.1039/b712606a
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McGhee AM, Kilner CA, Wilson AJ Conformer independent heterodimerisation of linear arrays using three hydrogen bonds, 2007
DOI:10.1039/b712603d

Campbell F, Plante JP, Carruthers CJ, Hardie MJ, Prior TJ, Wilson AJ Macrocyclic Scaffolds Derived From P-Aminobenzoic Acid Chemical Communications 2007 2240-2242, 2007
DOI:10.1039/b704366j

Wilson AJ Supramolecular Chemistry Annual Reports on the Progress of Chemistry Section B 103 174-192, 2007

Wilson AJ Non-Covalent Polymer Assembly Using Arrays of Hydrogen-Bonds Soft Matter 409-425, 2007

Wilson AJ, Hong J, Hamilton AD Recognition of Solvent Exposed Protein Surfaces Using Anthracene Derived Receptors Organic&Biomolecular Chemistry 5 276-285, 2007

Wilson A Supramolecular Chemistry Annual Reports on the Progress of Chemistry Section B 104 164-183, 2007

Grainger RS, Wilson AJ Highlights from the 41st EUCHEM conference on stereochemistry, Bürgenstock, Switzerland, April 2006 Chemical Communications 3269-3272, 2006
DOI:10.1039/b608451f

Zhou OH, Baldini L, Hong J, Wilson AJ, Hamilton AD Pattern Recognition of Proteins Based on an Array of Functionalized Porphyrins Journal of the American Chemical Society 128 2421-2425, 2006
DOI:10.1021/ja056833c

Wilson AJ Supramolecular Chemistry Annual Reports on the Progress of Chemistry Section B 102 148-167, 2006

Wilson AJ, van Gestel J, Sijbesma RP, Meijer EW Amplification of chirality in benzene tricarboxamide helical supramolecular polymers CHEM COMMUN 4404-4406, 2006
DOI:10.1039/b610051a

Wilson AJ, Grainger RS The Bürgenstock 41st EUCHEM Conference on Stereochemistry Chemical Communications 3269-3272, 2006

Wilson AJ, Masuda M, Sijbesma RP, Meijer EW Chiral Amplification in the Transcription of Supramolecular Helicity into a Polymer Backbone Angewandte Chemie: International Edition 44 2275-2279, 2005
DOI:10.1002/anie.200462347

Leigh DA, Venturini A, Wilson AJ, Wong JKY, Zerbetto F The mechanism of formation of amide-based interlocked compounds: Prediction of a new rotaxane-forming motif Chemistry - A European journal 10 4960-4969, 2004
DOI:10.1002/chem.200305662

Groves K, Wilson AJ, Hamilton AD Catalytic unfolding and proteolysis of cytochrome c induced by synthetic binding agents Journal of the American Chemical Society 126 12833-12842, 2004

Baldini L, Wilson AJ, Hong J, Hamilton AD Pattern-Based Detection of Different Proteins Using an Array of Fluorescent Protein Surface Receptors Journal of the American Chemical Society 126 5656-5657, 2004
DOI:10.1021/ja039562j

Wilson AJ, Hannam JS, Kidd TJ, Leigh DA "Magic Rod" Rotaxanes: The Hydrogen Bond-Directed Synthesis of Molecular Shuttles Under Thermodynamic Control Organic Letters 5 1907-1910, 2003

Wilson AJ, Groves K, Jain RK, Park HS, Hamilton AD Directed Denaturation: Room Temperature and Stoichiometric Unfolding of Cytochrome c by a Metalloporphyrin Dimer Journal of the American Chemical Society 125 4420-4421, 2003
DOI:10.1021/ja028574m

Leigh DA, Lusby PJ, Treat SJ, Wilson AJ, Wong JKY Benzylic Imine Catenates: Readily Accessible Octahedral Analogues of the Sauvage Catenates Angewandte Chemie: International Edition 40 1538-1543, 2001
DOI:10.1002/1521-3773(20010417)40:8<1538::AID-ANIE1538>3.0.CO;2-F

Wilson AJ, Kidd TJ, Leigh DA ‘“Organic Magic Rings”: The Hydrogen Bond Directed Assembly of Catenanes Under Thermodynamic Control’ Journal of the American Chemical Society 121 1599-1600, 1999

Miles JA, Yeo DJ, Rowell P, Rodriguez-Marin S, Pask CM, Warriner SL, Edwards TA, Wilson AJ Hydrocarbon constrained peptides–understanding preorganisation and binding affinity Chemical Science -,
DOI:10.1039/C5SC04048E
View abstract