School of Chemistry

Michael Webb

Lecturer
Research section: Organic Chemistry

Contact details

Keywords

Chemical Biology
Bioorganic Chemistry
Enzymology
Biosynthesis

Research interests

We are interested in the mechanistic basis for enzyme catalysis and biosynthesis and in the application of organic chemistry to develop tools to investigate these questions. Current interests include the enzymology of pantothenate and purine biosynthesis, the regulation of carbon fixation in plants and the development of probes for unusual protein phosphorylation events. In addition to organic synthesis, we use a wide range of complementary biochemical approaches including macromolecular crystallography and isothermal titration calorimetry to investigate these systems. More information about these approaches and current projects can be found at the group website

Useful links

Research group pages   
   
   

Selected publications

T. E. McAllister, M. G. Nix and M. E. Webb Fmoc-chemistry of a stable phosphohistidine analogue Chem. Commun. 2011, 47, 1297

M. T. Croft, M. Moulin, M. E. Webb and A. G. Smith Riboswitches regulate thiamine biosynthesis in the model green alga Chlamydomonas reinhardtii Proc. Natl. Acad. Sci 2007 104, 20770

M. E. Webb, A. Marqueet, R. R. Mendel, F. Rebeille and A. G. Smith Elucidating biosynthetic pathway for vitamins and cofactors Nat. Prod. Rep. 2007, 24, 988

F. Schmitzberger, C. M. C. Lobley, M. L. Kilkenny, M. E. Webb, D. Matak-Vinkovic, M. Vinkovic, D. J. Chiragdze, M. Witty, A. G. Smith, C. Abell and T. L. Blundell Structural insights into conformational constraints on protein self-processing in aspartate decarboxylase EMBO J. 2003, 22 6193