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Stuart Warriner

Senior Lecturer
Member of the Chemical Biology and Medicinal Chemistry group

Contact details

Room: G13b
Tel: +44 (0)113 3436437
Email: S.L.Warriner@leeds.ac.uk

Keywords

Carbohydrate Chemistry
Oligosaccharide Synthesis
Asymmetric Synthesis'



Photograph of Stuart Warriner

Research interests

The group is developing new methods for the synthesis and analysis of complex oligosaccharides which play a vital role in many intracellular systems. We also investigate new methods for asymmetric synthesis using novel bifunctional catalysts whilst other projects are developing new methods for drug discovery using evolutionary concepts. We also have collaborations with colleagues in Biochemistry which use the tools of Chemistry to prepare novel compounds for investigations into the pathways of protein folding.

Publications

Baker A, Hogg TL, Warriner SL Peroxisome protein import: a complex journey. Biochemical Society transactions 44 783-789, 2016
DOI:10.1042/bst20160036
View abstract

Burslem GM, Kyle HF, Breeze AL, Edwards TA, Nelson A, Warriner SL, Wilson AJ Towards "bionic" proteins: Replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics Chemical Communications 52 5421-5424, 2016
DOI:10.1039/c6cc01812b
View abstract

Azzarito V, Rowell P, Barnard A, Edwards TA, Macdonald A, Warriner SL, Wilson AJ Probing Protein Surfaces: QSAR Analysis using Helix Mimetics. ChemBioChem 17 768-773, 2016
DOI:10.1002/cbic.201500504
View abstract

Bhogal MS, Lanyon-Hogg T, Johnston KA, Warriner SL, Baker A Covalent label transfer between peroxisomal importomer components reveals export-driven import interactions Journal of Biological Chemistry 291 2460-2468, 2016
DOI:10.1074/jbc.M115.686501
View abstract

Miles JA, Yeo DJ, Rowell P, Rodriguez-Marin S, Pask CM, Warriner SL, Edwards TA, Wilson AJ Hydrocarbon constrained peptides-understanding preorganisation and binding affinity Chemical Science 7 3694-3702, 2016
DOI:10.1039/c5sc04048e
View abstract

Burslem GM, Kyle HF, Prabhakaran P, Breeze AL, Edwards TA, Warriner SL, Nelson A, Wilson AJ Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups Organic and Biomolecular Chemistry 14 3782-3786, 2016
DOI:10.1039/c6ob00078a
View abstract

Fisher MJ, Williamson DJ, Burslem GM, Plante JP, Manfield IW, Tiede C, Ault JR, Stockley PG, Plein S, Maqbool A, Tomlinson DC, Foster R, Warriner SL, Bon RS Trivalent Gd-DOTA reagents for modification of proteins RSC Advances 5 96194-96200, 2015
DOI:10.1039/c5ra20359g
View abstract

Karageorgis G, Dow M, Aimon A, Warriner S, Nelson A Activity-Directed Synthesis with Intermolecular Reactions: Development of a Fragment into a Range of Androgen Receptor Agonists Angewandte Chemie - International Edition 54 13538-13544, 2015
DOI:10.1002/anie.201506944
View abstract

Karageorgis G, Dow M, Aimon A, Warriner S, Nelson A Frontispiece: Activity-Directed Synthesis with Intermolecular Reactions: Development of a Fragment into a Range of Androgen Receptor Agonists. Angewandte Chemie (International ed. in English) 54 -, 2015
DOI:10.1002/anie.201584661
View abstract

Horner KA, Valette NM, Webb ME Strain-Promoted Reaction of 1,2,4-Triazines with Bicyclononynes Chemistry - A European Journal 21 14376-14381, 2015
DOI:10.1002/chem.201502397
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Morrison PM, Foley PJ, Warriner SL, Webb ME Chemical generation and modification of peptides containing multiple dehydroalanines Chemical Communications 51 13470-13473, 2015
DOI:10.1039/c5cc05469a
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Kyle HF, Wickson KF, Stott J, Burslem GM, Breeze AL, Tiede C, Tomlinson DC, Warriner SL, Nelson A, Wilson AJ, Edwards TA Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies Molecular BioSystems 11 2738-2749, 2015
DOI:10.1039/c5mb00284b
View abstract

Firth JD, Zhang R, Morgentin R, Guilleux R, Kalliokoski T, Warriner S, Foster R, Marsden SP, Nelson A Exploitation of the Ugi-Joullié Reaction in the Synthesis of Libraries of Drug-Like Bicyclic Hydantoins Synthesis (Germany) 47 2391-2406, 2015
DOI:10.1055/s-0034-1378704
View abstract

Azzarito V, Miles JA, Fisher J, Edwards TA, Warriner SL, Wilson AJ Stereocontrolled protein surface recognition using chiral oligoamide proteomimetic foldamers Chemical Science 6 2434-2443, 2015
DOI:10.1039/c4sc03559c
View abstract

Skoulding NS, Chowdhary G, Deus MJ, Baker A, Reumann S, Warriner SL Experimental validation of plant peroxisomal targeting prediction algorithms by systematic comparison of in vivo import efficiency and in vitro PTS1 binding affinity Journal of Molecular Biology 427 1085-1101, 2015
DOI:10.1016/j.jmb.2014.12.003
View abstract

Karageorgis G, Warriner S, Nelson A Efficient discovery of bioactive scaffolds by activity-directed synthesis NATURE CHEMISTRY 6 872-876, 2014
DOI:10.1038/NCHEM.2034

Branson TR, McAllister TE, Garcia-Hartjes J, Fascione MA, Ross JF, Warriner SL, Wennekes T, Zuilhof H, Turnbull WB A protein-based pentavalent inhibitor of the cholera toxin B-subunit. Angew Chem Int Ed Engl 53 8323-8327, 2014
DOI:10.1002/anie.201404397
View abstract

Lanyon-Hogg T, Hooper J, Gunn S, Warriner SL, Baker A PEX14 binding to Arabidopsis PEX5 has differential effects on PTS1 and PTS2 cargo occupancy of the receptor. FEBS Lett 588 2223-2229, 2014
DOI:10.1016/j.febslet.2014.05.038
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Macdonald SM, Gómez Martín JC, Chance R, Warriner S, Saiz-Lopez A, Carpenter LJ, Plane JMC A laboratory characterisation of inorganic iodine emissions from the sea surface: Dependence on oceanic variables and parameterisation for global modelling Atmospheric Chemistry and Physics 14 5841-5852, 2014
DOI:10.5194/acp-14-5841-2014
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Paudyal R, Jamaluddin A, Warren JP, Doyle SM, Robert S, Warriner SL, Baker A Trafficking modulator TENin1 inhibits endocytosis, causes endomembrane protein accumulation at the pre-vacuolar compartment and impairs gravitropic response in Arabidopsis thaliana. Biochem J 460 177-185, 2014
DOI:10.1042/BJ20131136
View abstract

Burslem GM, Kyle HF, Breeze AL, Edwards TA, Nelson A, Warriner SL, Wilson AJ Small-molecule proteomimetic inhibitors of the HIF-1α-p300 protein-protein interaction. Chembiochem 15 1083-1087, 2014
DOI:10.1002/cbic.201400009
View abstract

James T, Maclellan P, Burslem GM, Simpson I, Grant JA, Warriner S, Sridharan V, Nelson A A modular lead-oriented synthesis of diverse piperazine, 1,4-diazepane and 1,5-diazocane scaffolds. Org Biomol Chem 12 2584-2591, 2014
DOI:10.1039/c3ob42512f
View abstract

Henkelis JJ, Fisher J, Warriner SL, Hardie MJ Solvent-dependent self-assembly behaviour and speciation control of Pd6L8 metallo-supramolecular cages. Chemistry 20 4117-4125, 2014
DOI:10.1002/chem.201304437
View abstract

Tate DJ, Abdelbasit M, Kilner CA, Shepherd HJ, Warriner SL, Bushby RJ A simple route to derivatives of benzo[j]fluoranthene Tetrahedron 70 67-74, 2014
DOI:10.1016/j.tet.2013.11.029
View abstract

Martin HL, Adams M, Higgins J, Bond J, Morrison EE, Bell SM, Warriner S, Nelson A, Tomlinson DC High-content, high-throughput screening for the identification of cytotoxic compounds based on cell morphology and cell proliferation markers. PLoS One 9 e88338-, 2014
DOI:10.1371/journal.pone.0088338
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Yeo DJ, Warriner SL, Wilson AJ Monosubstituted alkenyl amino acids for peptide "stapling". Chem Commun (Camb) 49 9131-9133, 2013
DOI:10.1039/c3cc45231j
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Murphy NS, Prabhakaran P, Azzarito V, Plante JP, Hardie MJ, Kilner CA, Warriner SL, Wilson AJ Solid-phase methodology for synthesis of O-alkylated aromatic oligoamide inhibitors ofα-helix-mediated protein-protein interactions. Chemistry 19 5546-5550, 2013
DOI:10.1002/chem.201204098
View abstract

Maurya SK, Dow M, Warriner S, Nelson A Synthesis of skeletally diverse alkaloid-like molecules: Exploitation of metathesis substrates assembled from triplets of building blocks Beilstein Journal of Organic Chemistry 9 775-785, 2013
DOI:10.3762/bjoc.9.88
View abstract

Azzarito V, Warriner SL, Wilson AJ Oligobenzamide alpha-helix mimetic scaffolds: The role of non-covalent interactions in molecular recognition, 2013

Knapman TW, Valette NM, Warriner SL, Ashcroft AE Ion mobility spectrometry-mass spectrometry of intrinsically unfolded proteins: Trying to put order into disorder Current Analytical Chemistry 9 181-191, 2013
View abstract

Tate DJ, Abdelbasit M, Kilner CA, Shepherd HJ, Warriner SL, Bushby RJ A simple route to derivatives of benzo[j]fluoranthene Tetrahedron -, 2013
DOI:10.1016/j.tet.2013.11.029
View abstract

Brown L-A, Paudyal R, Baker A, Larson TR, Graham IA, Hawes C, Warriner SL An inhibitor of oil body mobilization in Arabidopsis New Phytologist -, 2013
DOI:10.1111/nph.12467
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Azzarito V, Prabhakaran P, Bartlett AI, Murphy NS, Hardie MJ, Kilner CA, Edwards TA, Warriner SL, Wilson AJ 2-O-alkylated para-benzamideα-helix mimetics: the role of scaffold curvature. Org Biomol Chem 10 6469-6472, 2012
DOI:10.1039/c2ob26262b
View abstract

Prabhakaran P, Azzarito V, Jacobs T, Hardie MJ, Kilner CA, Edwards TA, Warriner SL, Wilson AJ Conformational properties of O-alkylated benzamides Tetrahedron 68 4485-4491, 2012
DOI:10.1016/j.tet.2011.11.078
View abstract

Fascione MA, Webb NJ, Kilner CA, Warriner SL, Turnbull WB Stereoselective glycosylations using oxathiane spiroketal glycosyl donors. Carbohydr Res 348 6-13, 2012
DOI:10.1016/j.carres.2011.07.020
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Tate DJ, Anemian R, Bushby RJ, Nanan S, Warriner SL, Whitaker BJ Improved syntheses of high hole mobility phthalocyanines: A case of steric assistance in the cyclo-oligomerisation of phthalonitriles BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 8 120-128, 2012
DOI:10.3762/bjoc.8.14

Valette NM, Radford SE, Harris SA, Warriner SL Phosphorylation as a tool to modulate aggregation propensity and to predict fibril architecture. Chembiochem 13 271-281, 2012
DOI:10.1002/cbic.201100607
View abstract

Joce C, White R, Stockley PG, Warriner S, Turnbull WB, Nelson A Design, synthesis and in vitro evaluation of novel bivalent S-adenosylmethionine analogues. Bioorg Med Chem Lett 22 278-284, 2012
DOI:10.1016/j.bmcl.2011.11.017
View abstract

Murrison S, Maurya SK, Einzinger C, McKeever-Abbas B, Warriner S, Nelson A Synthesis of Skeletally Diverse Alkaloid-Like Small Molecules EUR J ORG CHEM 2354-2359, 2011
DOI:10.1002/ejoc.201100116

Brown LA, O'Leary-Steele C, Brookes P, Armitage L, Kepinski S, Warriner SL, Baker A A small molecule with differential effects on the PTS1 and PTS2 peroxisome matrix import pathways. Plant J 65 980-990, 2011
DOI:10.1111/j.1365-313X.2010.04473.x
View abstract

Prabhakaran P, Azzarito V, Jacobs T, Hardie MJ, Kilner CA, Edwards TA, Warriner SL, Wilson AJ Conformational properties of O-alkylated benzamides Tetrahedron -, 2011

Valette NM, Radford SE, Harris SA, Warriner SL Studying peptide aggregation with a series of phosphopeptide variants ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 240 -, 2010

Baker A, Sparkes IA, Brown LA, O'Leary-Steele C, Warriner SL Peroxisome biogenesis and positioning. Biochem Soc Trans 38 807-816, 2010
DOI:10.1042/BST0380807
View abstract

Campbell F, Plante JP, Edwards TA, Warriner SL, Wilson AJ N-alkylated oligoamide alpha-helical proteomimetics. Org Biomol Chem 8 2344-2351, 2010
DOI:10.1039/c001164a
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Lanyon-Hogg T, Warriner SL, Baker A Getting a camel through the eye of a needle: the import of folded proteins by peroxisomes. Biol Cell 102 245-263, 2010
DOI:10.1042/BC20090159
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Foit L, Morgan GJ, Kern MJ, Steimer LR, von Hacht AA, Titchmarsh J, Warriner SL, Radford SE, Bardwell JCA Optimizing Protein Stability In Vivo MOL CELL 36 861-871, 2009
DOI:10.1016/j.molcel.2009.11.022

Nelson A, Bone H, Damiano M, Welham M, Bartlett S, Perry A, Cordier CJ, Warriner S, Leach SG, Morton D, Letchford J Exploring biologically-relevant chemical space with macrocyclic ligands ABSTR PAP AM CHEM S 238 -, 2009

Nelson A, Bone H, Damiano M, Welham M, Bartlett S, Perry A, Cordier CJ, Warriner S, Leach SG, Morton D, Letchford J Exploring biologically-relevant chemical space with macrocyclic ligands ABSTR PAP AM CHEM S 238 -, 2009

O'Leary-Steele C, Cordier C, Hayes J, Warriner S, Nelson A A fluorous-tagged "safety catch" linker for preparing heterocycles by ring-closing metathesis. Org Lett 11 915-918, 2009
DOI:10.1021/ol802848j
View abstract

Plante JP, Burnley T, Malkova B, Webb ME, Warriner SL, Edwards TA, Wilson AJ Oligobenzamide proteomimetic inhibitors of the p53-hDM2 protein-protein interaction CHEM COMMUN 5091-5093, 2009
DOI:10.1039/b908207g

Morton D, Leach S, Cordier C, Warriner S, Nelson A Synthesis of Natural-Product-Like Molecules with Over Eighty Distinct Scaffolds ANGEW CHEM INT EDIT 48 104-109, 2009
DOI:10.1002/anie.200804486

Murrison S, Glowacki D, Einzinger C, Titchmarsh J, Bartlett S, McKeever-Abbas B, Warriner S, Nelson A Remarkably slow rotation about a single bond between an sp(3)-hybridised carbon atom and an aromatic ring without ortho substituents. Chemistry 15 2185-2189, 2009
DOI:10.1002/chem.200802127
View abstract

Joce C, Caryl J, Stockley PG, Warriner S, Nelson A Identification of stable S-adenosylmethionine (SAM) analogues derivatised with bioorthogonal tags: effect of ligands on the affinity of the E. coli methionine repressor, MetJ, for its operator DNA ORG BIOMOL CHEM 7 635-638, 2009
DOI:10.1039/b816495a

Norcross NR, Melbardis JP, Solera MF, Sephton MA, Kilner C, Zakharov LN, Astles PC, Warriner SL, Blakemore PR Total synthesis of (+/-)-alpha-isosparteine, (+/-)-beta-isosparteine, and (+/-)-sparteine from a common tetraoxobispidine intermediate J ORG CHEM 73 7939-7951, 2008
DOI:10.1021/jo8013512

Stöckmann H, Bronowska A, Syme NR, Thompson GS, Kalverda AP, Warriner SL, Homans SW Residual ligand entropy in the binding of p-substituted benzenesulfonamide ligands to bovine carbonic anhydrase II. J Am Chem Soc 130 12420-12426, 2008
DOI:10.1021/ja803755m
View abstract

Murrison SL, Nelson AS, Warriner S, McKeever-Abbas B ORGN 668-Diversity-oriented synthesis of polycyclic alkaloid-like libraries., 2008

Murrison SL, Nelson AS, Warriner S, McKeever-Abbas B ORGN 668-Diversity-oriented synthesis of polycyclic alkaloid-like libraries., 2008

Leach SG, Cordier CJ, Morton D, McKiernan GJ, Warriner S, Nelson A A fluorous-tagged linker from which small molecules are released by ring-closing metathesis J ORG CHEM 73 2753-2759, 2008
DOI:10.1021/jo7026273

Plante J, Campbell F, Malkova B, Kilner C, Warriner SL, Wilson AJ Synthesis of functionalised aromatic oligamide rods. Org Biomol Chem 6 138-146, 2008
DOI:10.1039/b712606a
View abstract

Cordier C, Morton D, Leach S, Woodhall T, O'Leary-Steele C, Warriner S, Nelson A An efficient method for synthesising unsymmetrical silaketals: substrates for ring-closing, including macrocycle-closing, metathesis ORG BIOMOL CHEM 6 1734-1737, 2008
DOI:10.1039/b804769n

Nagalingam AC, Radford SE, Warriner SL Avoidance of epimerization in the synthesis of peptide thioesters using Fmoc protection SYNLETT 2517-2520, 2007
DOI:10.1055/s-2007-986631

Gunn SJ, Baker A, Bertram RD, Warriner SL A Novel Approach to the Solid-Phase Synthesis of Peptides with a Tetrazole at the C-Terminus Synlett 2007 2643-2646, 2007
DOI:10.1055/s-2007-986661

Ansell RJ, Barrett SA, Meegan JE, Warriner SL On the interactions of alkyl 2-hydroxycarboxylic acids with alkoxysilanes: Selective esterification of simple 2-hydroxycarboxylic acids Chemistry a European journal 13 4654-4664, 2007
DOI:10.1002/chem.200601859

Gunn SJ, Warriner SL, White JW Product class 13: glycosyl halides In Science of Synthesis , 2007

von Angerer S, Warriner SL Product class 6: acyclic and semicyclic O/O acetals In Science of Synthesis , 2007

Warriner SL Sciences of Synthesis. Compounds with Two Carbon-Heteratom Bonds, 2007

Blakemore PR, Norcross NR, Warriner SL, Astles PC A stereocontrolled synthesis of (+/-)-beta-isosparteine HETEROCYCLES 70 609-+, 2006

Bartlett S, Beddard GS, Jackson RM, Kayser V, Kilner C, Leach A, Nelson A, Oledzki PR, Parker P, Reid GD, Warriner SL Comparison of the ATP binding sites of protein kinases using conformationally diverse bisindolylmaleimides. J Am Chem Soc 127 11699-11708, 2005
DOI:10.1021/ja050576u
View abstract

Burt J, Dean T, Warriner S The parallel synthesis of a disaccharide library using a solid phase, peptide-templated strategy. Chemical communications (Cambridge, England) 454-455, 2004
View abstract

Mocquet CM, Warriner SL Metal-Free Bifunctional Catalysis of the Asymmetric Baylis-Hillman Reaction Synlett 2 356-358, 2004
DOI:10.1055/s-2003-44982

Burt JF, Dean T, Warriner SL The parallel synthesis of a disaccharide library using a solid phase, peptide-templated strategy Chemical Communications 4 454-455, 2003
DOI:10.1039/b313571c

Bartlett SJ, Hodgson RD, Holland JM, Jones M, Kilner CA, Nelson AS, Warriner SL Exploiting predisposition in the stereoselective synthesis of mono-, bi- and tetracyclic oxygen heterocycles: Equilibration between, and trapping of, alternative di- and tetraacetals Organic&Biomolecular Chemistry 1 2393-2402, 2003
DOI:10.1039/b303089j

Greenwell DR, Ibnouzaki AF, Warriner SL Peptide-templated saccharide synthesis on a solid support. Angew Chem Int Ed Engl 41 1215-1218, 2002

Greenwell DR, Ibnouzaki AF, Warriner SL Peptide-templated saccharide synthesis on a solid support ANGEW CHEM INT EDIT 41 1215-+, 2002

Greenwell DR, Ibnouzaki AF, Warriner SL Peptide-templated saccharide synthesis on a solid support ANGEW CHEM INT EDIT 41 1215-+, 2002

Grahn E, Stonehouse NJ, Adams CJ, Fridborg K, Beigelman L, Matulic-Adamic J, Warriner SL, Stockley PG, Liljas L Deletion of a single hydrogen bonding atom from the MS2 RNA operator leads to dramatic rearrangements at the RNA-coat protein interface Nucleic Acids Research 28 4611-4616, 2000
View abstract

Marko IE, Warriner SL, Augustyns B Radical-initiated, skeletal rearrangements of bicyclo [2.2.2] lactones. Organic Letters 2 3123-3125, 2000

Green SM, Nelson AS, Warriner SL, Whittaker BP Synthesis and investigation of the configurational stability of some dimethylammonium borate salts. Royal Society of Chemistry. Journal: Perkin Transactions 1 5 -, 2000

Green SM, Nelson AS, Warriner SL, Whittaker BP Synthesis and investigation of the configurational stability of some dimethylammonium borate salts. Royal Society of Chemistry. Journal: Perkin Transactions 1 5 -, 2000

Douglas NL, Ley SV, Lucking U, Warriner SL Tuning glycoside reactivity: A new tool for efficient oligosaccharide synthesis Royal Society of Chemistry. Journal: Perkin Transactions 1 51-65, 1998

Grice P, Ley SV, Pietruszka J, Osborn HMI, Priepke HWM, Warriner SL A new strategy for oligosaccharide assembly exploiting cyclohexane-1,2-diacetal methodology: An efficient synthesis of a high mannose type nonasaccharide Chemistry a European journal 3 431-440, 1997

Grice P, Ley SV, Pietruszka J, Priepke HWM, Warriner SL Preparation, structure, derivatisation and nmr data of cyclohexane-1,2-diacetal protected carbohydrates Royal Society of Chemistry. Journal: Perkin Transactions 1 4 351-363, 1997

Marko IE, Chelle-Regnaut I, Leroy B, Warriner SL Remarkable effect of basic ligands in the lanthanide-catalysed enantioselective cycloadditions of 3-carbomethyoxy pyrone Tetrahedron Letters 38 4269-4272, 1997

Fowler JM, Thorp-Greenwood FL, Warriner SL, Willans CE, Hardie MJ M12L8 metallo-supramolecular cube with cyclotriguaiacylene-type ligand: spontaneous resolution of cube and its constituent host ligand Chemical Communications -,
DOI:10.1039/C6CC04130B
View abstract