School of Chemistry

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Paul Taylor

Professor of Chemical Education,
Director of Student Education
Member of the Chemical Biology and Medicinal Chemistry group

Contact details

Room: G52e
Tel: +44 (0)113 3436529
Email: P.C.Taylor@leeds.ac.uk

Keywords

Chemical Genomics
Drug Reprofiling
Cancer Treatments
Evolution
Chemical Education

Photograph of Paul Taylor

Research interests

A Chemical Genomics approach to Cancer Treatment: Our methods link drugs and natural products to genes that may affect cancer, for example drug candidate VAL401, being developed by ValiSeek Limited. VAL401 is the reformulation of an existing clinical drug to enable use instead in the treatment of cancer (Dilly et al., 2014). Preclinical data indicate potential use of the reformulated drug in lung, pancreatic, breast and prostate cancers.

The Evolutionary Origins of Chemical Messengers in Humans: A collaborative programme with Professor David Scanlan (School of Life Sciences, University of Warwick) and Dr Andrew Millard (Warwick Medical School) building on the finding that retinoic acid is not, as generally thought, an animal "invention" but originates in cyanobacteria (Millard et al., 2014). We are currently studying further lateral genetic transfer events using phylogenetic analysis and experimental study of chemical signals in "model" cyanobacteria using analytical chemistry and genetics techniques, all leading to new insights into both ecology and medicine.

Chemical Education: A student-engaged research programme (Lambert et al., 2012) around topics such as research-based learning, interdisciplinarity, internationalisation and enterprise education in tertiary education.

Publications

Millard A; Scanlan DJ; Gallagher C; Marsh A; Taylor PC Unexpected evolutionary proximity of eukaryotic and cyanobacterial enzymes responsible for biosynthesis of retinoic acid and its oxidation Molecular BioSystems 10 380-383, 2014
DOI:10.1039/c3mb70447e
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Apps JFS; Livingston AG; Parrett MR; Pounder RJ; Taylor PC; Turner AR Racemisation of 1-arylethylamines with Shvo-type organoruthenium catalysts Synlett 25 1391-1394, 2014
DOI:10.1055/s-0033-1341228
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Taylor PC; Clark AJ; Marsh A; Singer DRJ; Dilly SJ A chemical genomics approach to identification of interactions between bioactive molecules and alternative reading frame proteins Chemical Communications 49 9588-9590, 2013
DOI:10.1039/c3cc44647f
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Dobrzanska DA; Cooper AL; Dowson CG; Evans SD; Fox DJ; Johnson BR; Biggs CI; Randev RK; Stec HM; Taylor PC; Marsh A Oxidation of tertiary amine-derivatized surfaces to control protein adhesion Langmuir 29 2961-2970, 2013
DOI:10.1021/la4003719
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Dobrzanska DA; Cooper A(; Dowson CG; Evans SD; Fox DJ(J); Johnson BR; Biggs CI; Randev R; Stec HM; Taylor PC; Marsh A( Oxidation of tertiary amine-derivatized surfaces to control protein adhesion Langmuir Volume 29 2961-2970, 2013
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Issa RA; Barker GC; Marsh A; Slade SE; Taylor PC An optimized method for profiling glucosinolate content in brassica enabling plant line selection and quantitative trait locus mapping International Journal of Nutrition and Food Sciences Volume 2 author_id-6166, 2013

Dobrzanska DA; Cooper AL; Dowson CG; Evans SD; Haynes T; Johnson BRG; Stec HM; Taylor PC; Marsh A Protein-adhesive and protein-resistant functionalized silicon surfaces, 2012
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Watkins J; Marsh A(; Taylor PC; Singer DRJ Examining the intersection between network pharmacology and personalizing medicines, 2011

Watkins J; Marsh A; Taylor PC; Singer DRJ EXAMINING THE INTERSECTION BETWEEN NETWORK PHARMACOLOGY AND PERSONALIZING MEDICINES BASIC&CLINICAL PHARMACOLOGY&TOXICOLOGY 109 23-23, 2011

Dilly SJ; Clark AJ(J); Mitchell DA; Marsh A(; Taylor PC Using the Man9(GlcNAc)2 ? DC-SIGN pairing to probe specificity in photochemical immobilization Molecular BioSystems Vol.7 116-118, 2011
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Dilly SJ; Clark AJ; Mitchell DA; Marsh A; Taylor PC Using the Man9(GlcNAc)2-DC-SIGN pairing to probe specificity in photochemical immobilization Molecular BioSystems 7 116-118, 2011
DOI:10.1039/c0mb00118j
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Watkins J; Marsh A; Taylor PC; Singer DRJ Personalized medicine: The impact on chemistry Therapeutic Delivery 1 651-665, 2010
DOI:10.4155/tde.10.64
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Watkins J; Marsh A; Taylor PC; Singer DRJ Personalized medicine : the impact on chemistry Therapeutic Delivery Vol.1 651-665, 2010
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Chang JWW; Ton TMU; Tania S; Taylor PC; Chan PWH Practical copper(I)-catalysed amidation of aldehydes Chemical Communications Vol.46 922-924, 2010
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Chang JWW; Ton TMU; Tania S; Taylor PC; Chan PWH Practical copper(I)-catalysed amidation of aldehydes Chemical Communications 46 922-924, 2010
DOI:10.1039/b918588g
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Taylor PC Synthetic methods: Part (iii) heteroatom chemistry Annual Reports on the Progress of Chemistry - Section B 105 75-92, 2009
DOI:10.1039/b822046h
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Ladwa SR; Dilly SJ; Clark AJ; Marsh A; Taylor PC Rapid identification of a putative interaction betweenβ2- adrenoreceptor agonists and ATF4 using a chemical genomics approach ChemMedChem 3 742-744, 2008
DOI:10.1002/cmdc.200700317
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Ladwa SR; Dilly SJ; Clark AJ(J); Marsh A(; Taylor PC Rapid identification of a putative interaction between beta(2)-adrenoreceptor agonists and ATF4 using a chemical genomics approach ChemMedChem Vol.3 742-744, 2008
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Adjiman CS; Clarke AJ; Cooper G; Taylor PC Solvents for ring-closing metathesis reactions Chemical Communications 2806-2808, 2008
DOI:10.1039/b802921k
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Taylor PC; Apps JFS-L Synthetic methods: Part (iii) Heteroatom chemistry Annual Reports on the Progress of Chemistry - Section B 104 49-67, 2008
DOI:10.1039/b717023h
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Adjiman CS; Clarke AJ; Cooper G; Taylor PC A rational approach to solvent choice in the development of homogeneous catalytic reaction systems, 2008
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Adjiman CS; Clarke AJ; Cooper G; Taylor PC A rational approach to solvent choice in the development of homogeneous catalytic reaction systems, 2008

Adjiman CS; Clarke AJ; Cooper G; Taylor PC A rational approach to solvent choice in the development of homogeneous catalytic reaction systems, 2008
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Smith TR; Clark AJ; Napier RM; Taylor PC; Thompson AJ; Marsh A Function and stability of abscisic acid acyl hydrazone conjugates by LC-MS2 of ex vivo samples Bioconjugate Chemistry Vol.18 1355-1359, 2007
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Smith TR; Clark AJ; Napier R; Taylor PC; Thompson AJ; Marsh A Function and stability of abscisic acid acyl hydrazone conjugates by LC-MS2 of ex vivo samples Bioconjugate Chemistry 18 1355-1359, 2007
DOI:10.1021/bc070069x
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Roengpithya C; Patterson DA; Livingston AG; Taylor PC; Irwin JL; Parrett MR Towards a continuous dynamic kinetic resolution of 1-phenylethylamine using a membrane assisted, two vessel process Chemical Communications 3462-3463, 2007
DOI:10.1039/b709035h
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Dilly SJ; Bell MJ; Clark AJ; Marsh A; Napier RM; Sergeant MJ; Thompson AJ; Taylor PC A photoimmobilisation strategy that maximises exploration of chemical space in small molecule affinity selection and target discovery Chemical Communications 2808-2810, 2007
DOI:10.1039/b704271j
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Taylor PC; Parrett MR Synthetic methods: Part (iii) Heteroatom methods Physical Chemistry Chemical Physics 9 47-67, 2007
DOI:10.1039/b617791n
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Roengpithya C; Patterson DA; Taylor PC; Livingston AG Development of stable organic solvent nanofiltration membranes for membrane enhanced dynamic kinetic resolution, 2006
DOI:10.1016/j.desal.2006.03.045

Roengpithya C; Patterson DA; Gibbins EJ; Taylor PC; Livingston AG Investigation of the compatibility of racemization and kinetic resolution for the dynamic kinetic resolution of an allylic alcohol Industrial and Engineering Chemistry Research 45 7101-7109, 2006
DOI:10.1021/ie060394o
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Dilly SJ; Beecham MP; Brown SP; Griffin JM; Clark AJ; Griffin CD; Marshall J; Napier RM; Taylor PC; Marsh A Novel tertiary amine oxide surfaces that resist nonspecific protein adsorption Langmuir Vol.22 8144-8150, 2006
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Dilly SJ; Beecham MP; Brown SP; Griffin JM; Clark AJ; Griffin CD; Marshall J; Napier RM; Taylor PC; Marsh A Novel tertiary amine oxide surfaces that resist nonspecific protein adsorption Langmuir 22 8144-8150, 2006
DOI:10.1021/la060743j
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Dilly SJ; Carlisle SJ; Clark AJ; Shepherd AR; Smith SC; Taylor PC; Marsh A Practical syntheses of [1,3,5]-triazine dendritic molecules on solid supports Journal of Polymer Science, Part A: Polymer Chemistry 44 2248-2259, 2006
DOI:10.1002/pola.21336
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Dilly SJ; Carlisle SJ; Clarke AJ; Shepherd AR; Smith SC; Taylor PC; Marsh A Practical syntheses of [1,3,5]-triazine dendritic molecules on solid supports Journal of Polymer Science. Part A, Polymer Chemistry Volume 44 2248-2259, 2006
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Dilly SJ; Beecham MP; Brown SP; Griffin JM; Clark AJ; Griffin CD; Marshall J; Napier RM; Taylor PC; Marsh A Novel tertiary amine oxide surfaces that resist non-specific protein adsorption Langmuir Vol.22 8144-8150, 2006
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Clarkson GJ; Livingston AG; Muir JC; Taylor PC The absolute configuration of (+)-(E)-4-phenylbut-3-ene-2-ol Organic&Biomolecular Chemistry Volume 4 2081-2081, 2006
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Smith TR; Clark AJ; Clarkson GJ; Taylor PC; Marsh A Concise enantioselective synthesis of abscisic acid and a new analogue Organic and Biomolecular Chemistry 4 4186-4192, 2006
DOI:10.1039/b611880a
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Clarkson G; Livingston AG; Muir JC; Taylor PC The absolute configuration of (+)-(E)-4-phenylbut-3-ene-2-ol Organic and Biomolecular Chemistry 4 2081-2081, 2006
DOI:10.1039/b603934k
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Taylor PC; Wall MD; Woodward PR Synthesis of dendritic oligo(aryl sulfone)s as supports for synthesis Tetrahedron 61 12314-12322, 2005
DOI:10.1016/j.tet.2005.09.103
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Gibbins EJ; Irwin JL; Livingston AG; Muir JC; Patterson DA; Roengpithya C; Taylor PC An improved protocol for the synthesis and nanofiltration of Kim and Park's aminocyclopentadienyl ruthenium chloride racemisation catalyst Synlett 2993-2995, 2005
DOI:10.1055/s-2005-921886
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Gibbins E; Irwin JL; Livingston AG; Muir JC; Patterson DA; Roengpithya C; Taylor PC Dynamic kinetic resolution of racemates using membrane-separated catalysts., 2005

Albone DP; Challenger S; Derrick AM; Fillery SM; Irwin JL; Parsons CM; Takada H; Taylor PC; Wilson DJ Amination of ethers using chloramine-T hydrate and a copper(I) catalyst Organic and Biomolecular Chemistry 3 107-111, 2005
DOI:10.1039/b410883c
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Storr MT; Taylor PC; Monfort J-P; Rodger PM Kinetic Inhibitor of Hydrate Crystallization Journal of the American Chemical Society 126 1569-1576, 2004
DOI:10.1021/ja035243g
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Bratt MO; Taylor PC Synthesis of carbonates and related compounds from carbon dioxide via methanesulfonyl carbonates Journal of Organic Chemistry 68 5439-5444, 2003
DOI:10.1021/jo026753g
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Moon C; Taylor PC; Rodger PM Molecular dynamics study of gas hydrate formation Journal of the American Chemical Society 125 4706-4707, 2003
DOI:10.1021/ja028537v
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Taylor PC; Fillery SM; Irwin JL; Parsons CM; Wilson DJ Amination of activated hydrocarbons using chloramine-T hydrate and copper or rhodium catalysts: Mechanistic aspects, 2003

Parsons CM; Taylor PC; Irwin JL; Wilson DJ; Fillery SM Amination of activated hydrocarbons using chloramine-T and copper catalysts; Applications to enantioselective synthesis., 2003

Moon C; Taylor PC; Rodger PM Clathrate nucleation and inhibition from a molecular perspective Canadian Journal of Physics 81 451-457, 2003
DOI:10.1139/p03-035
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Clark AJ; Echenique J; Haddleton DM; Straw TA; Taylor PC A nonisocyanate route to monodisperse branched polyurethanes Journal of Organic Chemistry 66 8687-8689, 2001
DOI:10.1021/jo016075i

Taylor PC; Albone DP; Challenger S; Derrick AM; Fillery SM; Parsons CM; Takada H Catalytic amination of ethers. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 221 U207-U207, 2001

Wall MD; Taylor PC; Woodward PR Poly(arylsulfone) dendrimers as "NMR quiet" homogeneous supports in combinatorial chemistry. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 221 U119-U119, 2001

Hannon MJ; Mayers PC; Taylor PC A dendritic structure containing a designed cleft which controls ligand coordination behavior in an analogous way to proteins Angewandte Chemie - International Edition 40 1081-1084, 2001
DOI:10.1002/1521-3773(20010316)40:6<1081::AID-ANIE10810>3.0.CO;2-#
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Hannon MJ; Mayers PC; Taylor PC A dendritic structure containing a designed cleft which controls ligand coordination behavior in an analogous way to proteins ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 40 1081-+, 2001
DOI:10.1002/1521-3773(20010316)40:6<1081::AID-ANIE10810>3.0.CO;2-#

Rayner CP; Clark AJ; Rooke SM; Sparey TJ; Taylor PC Diastereoselective addition reactions of racemic chiral vinyl sulfimides Journal of the Chemical Society, Perkin Transactions 1 79-87, 2001
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Alcock NW; Clase HJ; Duncalf DJ; Hart SL; McCamley A; McCormack PJ; Taylor PC Synthesis of racemic chiral-at-metal complexes of the Group 4 metals Journal of Organometallic Chemistry 605 45-54, 2000
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Albone DP; Aujla PS; Takada H; Taylor PC; Derrick AM; Challenger S Metal-catalyzed atom transfer to alkenes and activated hydrocarbons. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 219 U220-U220, 2000

Hannon MJ; Mayers PC; Taylor PC Synthesis and characterisation of water-soluble poly(aryl ether) dendrimers for encapsulation of biomimetic active site analogues Journal of the Chemical Society, Perkin Transactions 1 1881-1889, 2000
DOI:10.1039/b002026p
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Rayner CP; Clark AJ; Rooke SM; Sparey TJ; Taylor PC Diastereoselective addition reactions of racemic chiral vinyl sulfimides Journal of the Chemical Society, Perkin Transactions 1 79-87, 2000
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Hart SL; McCamley A; McCormack PJ; Taylor PC Synthesis of racemic chiral-at-metal complexes of the Group 4 metals by a lithium chloride catalysed ligand redistribution reaction (vol 553, pg 507, 1998) JOURNAL OF ORGANOMETALLIC CHEMISTRY 584 382-385, 1999
DOI:10.1016/S0022-328X(98)00799-2

Hart SL; McCamley A; Taylor PC Ti(η5-C5H5)(η5-C5H4(t)Bu)(CH2Ph)2; a probe of the course of the petasis benzylidenation reaction Synlett 90-92, 1999
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Clark AJ; Coleshill AA; Haddleton DM; Isles SJ; Sahota HS; Taylor PC; Yeates SG Changes in the homogeneity of poly(arylester) dendrimers during the matrix-assisted laser desorption/ionisation mass spectrometry experiment European Journal of Mass Spectrometry 5 273-277, 1999
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Albone DP; Aujla PS; Challenger S; Derrick AM; Taylor PC Catalytic nitrene transfer from chloramine-T Phosphorus, Sulfur and Silicon and Related Elements 153-154 347-348, 1999
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Hart SL; McCamley A; Taylor PC Ti(eta(5)-C5H5)(eta(5)-(C5H4Bu)-Bu-t)(CH2Ph)(2); a probe of the course of the petasis benzylidenation reaction SYNLETT 90-92, 1999

Albone DP; Aujla PS; Taylor PC; Challenger S; Derrick AM A simple copper catalyst for both aziridination of alkenes and amination of activated hydrocarbons with chloramine-T trihydrate Journal of Organic Chemistry 63 9569-9571, 1998
DOI:10.1021/jo981335q

Hannon MJ; Mayers PC; Taylor PC Preparation of substituted tris(2-pyridyl)methanol derivatives as mimics of the metal binding site of carbonic anhydrase Tetrahedron Letters 39 8509-8512, 1998
DOI:10.1016/S0040-4039(98)01850-4
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Baird CP; Taylor PC Enantioselective synthesis of epoxides and aziridines by asymmetric methylidene transfer from a sulfimide to carbonyl compounds and imines Journal of the Chemical Society - Perkin Transactions 1 3399-3403, 1998
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Albone DP; Aujla PS; Taylor PC; Challenger S; Derrick AM A simple, chemoselective copper catalyst for both aziridination of alkenes and amination of activated hydrocarbons with chloramine-T trihydrate ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 216 U579-U579, 1998

Clark AJ; Haddleton DM; Hannon MJ; Isles SJ; Mayers PC; Taylor PC Polyester dendrimers as metalloenzyme analogues ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 216 U372-U372, 1998

Deeth R; McCamley A; McCormack P; Taylor PC Synthetic and computer aided design of novel enantioselective "chiral-at-metal" Lewis acid catalyst precursors ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 216 U549-U549, 1998

Hart SL; McCamley A; McCormack PJ; Taylor PC Synthesis of racemic chiral-at-metal complexes of the group 4 metals by a lithium chloride catalysed ligand redistribution reaction Journal of Organometallic Chemistry 553 507-509, 1998
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Aujla PS; Baird CP; Taylor PC; Mauger H; Vallée Y Can chloramine-T be a nitrene transfer agent? Tetrahedron Letters 38 7453-7456, 1997
DOI:10.1016/S0040-4039(97)01754-1
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Coleshill AA; Haddleton DM; Taylor PC; Yeates SG Synthesis of poly(alkylester) dendrimers. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 213 77-POLY, 1997

Coleshill AA; Haddleton DM; Taylor PC; Yeates SG Synthesis of poly(alkylester) dendrimers American Chemical Society, Polymer Preprints, Division of Polymer Chemistry 38 135-136, 1997

Hanrahan JR; Taylor PC; Errington W The synthesis of 3-phosphonocyclobutyl amino acid analogues of glutamic acid via diethyl 3-oxycyclobutylphosphonate, a versatile synthetic intermediate Journal of the Chemical Society - Perkin Transactions 1 493-502, 1997
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Baird CP; Clark AJ; Rooke SM; Sparey TJ; Taylor PC Sulfimide-mediated asymmetric synthesis, 1997
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Takada H; Nishibayashi Y; Ohe K; Uemura S; Baird CP; Sparey TJ; Taylor PC Catalytic Asymmetric Sulfimidation Journal of Organic Chemistry 62 6512-6518, 1997
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Hart SL; Duncalf DJ; Hastings JJ; McCamley A; Taylor PC Synthesis and characterisation of (η5-cyclopentadienyl)(η5-ring)titanium alkyl (ring = indenyl or C5H4But) complexes. Crystal and molecular structure of racemic [Ti(η5-C5H5)(η5-C 9H7)(CH2SiMe3)CI] Journal of the Chemical Society - Dalton Transactions 2843-2849, 1996
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Haddleton DM; Sahota HS; Taylor PC; Yeates SG Synthesis of polyester dendrimers Journal of the Chemical Society - Perkin Transactions 1 649-656, 1996
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Hart SL; McCamley A; Taylor PC Catalytic asymmetric synthesis of chiral-at-metal organometallics. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 211 589-INOR, 1996

Smith G; Sparey TJ; Taylor PC The potential of sulfimides as chiral acyl anion equivalents Journal of the Chemical Society - Perkin Transactions 1 313-317, 1996
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Clark AJ; Rooke S; Sparey TJ; Taylor PC Synthesis of styryl tetrahydrofurans and tetrahydropyrans via addition of radicals to unsaturated sulfimides Tetrahedron Letters 37 909-912, 1996
DOI:10.1016/0040-4039(95)02277-5
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Baird CP; Taylor PC Asymmetric synthesis of epoxides using chiral sulfimides Journal of the Chemical Society, Chemical Communications 893-894, 1995
DOI:10.1039/C39950000893
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Bond TJ; Jenkins R; Taylor PC The origins of chemoselectivity in the hydrogenation of indolizidine precursors Tetrahedron Letters 35 9263-9266, 1994
DOI:10.1016/0040-4039(94)88483-8
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ERRINGTON W; SPAREY T; TAYLOR P ANTI,ANTI-N-(2,6-DIMETHYL-1,3,5-TRITHIAN-1-YLIDENE)-4-METHYLBENZENESULFONAMIDE ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS 50 1821-1823, 1994
DOI:10.1107/S0108270194007110

DERRICK P; HADDLETON D; SAHOTA H; TAYLOR P; LLOYD P; YEATES S SYNTHESIS AND CHARACTERIZATION BY MATRIX-ASSISTED LASER-DESORPTION MASS-SPECTROMETRY OF AROMATIC POLYESTER DENDRIMERS ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 208 271-POLY, 1994

Sahota HS; Lloyd PM; Yeates SG; Derrick PJ; Taylor PC; Haddleton DM Characterisation of aromatic polyester dendrimers by matrix-assisted laser desorption ionisation mass spectrometry Journal of the Chemical Society, Chemical Communications 2445-2446, 1994
DOI:10.1039/C39940002445
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Errington W; Sparey TJ; Taylor PC Conformational preferences of sulfimides Journal of the Chemical Society, Perkin Transactions 2 1439-1444, 1994
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Bond TJ; Jenkins R; Ridley AC; Taylor PC Efficient asymmetric synthesis of indolizidine building blocks Journal of the Chemical Society, Perkin Transactions 1 2241-2242, 1993
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