School of Chemistry

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Paul Taylor

Professor of Chemical Education,
Director of Student Education
Member of the Chemical Biology and Medicinal Chemistry group

Contact details

Room: G52e
Tel: +44 (0)113 3436529
Email: P.C.Taylor@leeds.ac.uk

Keywords

Chemical Genomics
Drug Reprofiling
Cancer Treatments
Evolution
Chemical Education

Photograph of Paul Taylor

Research interests

A Chemical Genomics approach to Cancer Treatment: Our methods link drugs and natural products to genes that may affect cancer, for example drug candidate VAL401, being developed by ValiSeek Limited. VAL401 is the reformulation of an existing clinical drug to enable use instead in the treatment of cancer (Dilly et al., 2014). Preclinical data indicate potential use of the reformulated drug in lung, pancreatic, breast and prostate cancers.

The Evolutionary Origins of Chemical Messengers in Humans: A collaborative programme with Professor David Scanlan (School of Life Sciences, University of Warwick) and Dr Andrew Millard (Warwick Medical School) building on the finding that retinoic acid is not, as generally thought, an animal "invention" but originates in cyanobacteria (Millard et al., 2014). We are currently studying further lateral genetic transfer events using phylogenetic analysis and experimental study of chemical signals in "model" cyanobacteria using analytical chemistry and genetics techniques, all leading to new insights into both ecology and medicine.

Chemical Education: A student-engaged research programme (Lambert et al., 2012) around topics such as research-based learning, interdisciplinarity, internationalisation and enterprise education in tertiary education.

Publications

Hartswood M; Procter RN; Taylor PC; Blot L Computer supported cooperative learning in the workplace : a case study in radiology, 2013

Dobrzanska DA; Cooper A(; Dowson CG; Evans SD; Fox DJ(J); Johnson BR; Biggs CI; Randev R; Stec HM; Taylor PC; Marsh A( Oxidation of tertiary amine-derivatized surfaces to control protein adhesion Langmuir Volume 29 2961-2970, 2013
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Issa RA; Barker GC; Marsh A; Slade SE; Taylor PC An optimized method for profiling glucosinolate content in brassica enabling plant line selection and quantitative trait locus mapping International Journal of Nutrition and Food Sciences Volume 2 author_id-6166, 2013

Dobrzanska DA; Cooper AL; Dowson CG; Evans SD; Haynes T; Johnson BRG; Stec HM; Taylor PC; Marsh A Protein-adhesive and protein-resistant functionalized silicon surfaces, 2012
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Watkins J; Marsh A(; Taylor PC; Singer DRJ Examining the intersection between network pharmacology and personalizing medicines, 2011

Dilly SJ; Clark AJ(J); Mitchell DA; Marsh A(; Taylor PC Using the Man9(GlcNAc)2 ? DC-SIGN pairing to probe specificity in photochemical immobilization Molecular BioSystems Vol.7 116-118, 2011
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Watkins J; Marsh A; Taylor PC; Singer DRJ Personalized medicine : the impact on chemistry Therapeutic Delivery Vol.1 651-665, 2010
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Chang JWW; Ton TMU; Tania S; Taylor PC; Chan PWH Practical copper(I)-catalysed amidation of aldehydes Chemical Communications Vol.46 922-924, 2010
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Ladwa SR; Dilly SJ; Clark AJ(J); Marsh A(; Taylor PC Rapid identification of a putative interaction between beta(2)-adrenoreceptor agonists and ATF4 using a chemical genomics approach ChemMedChem Vol.3 742-744, 2008
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Adjiman CS; Clarke AJ; Cooper G(; Taylor PC Solvents for ring-closing metathesis reactions Chemical Communications Vol.44 2806-2808, 2008
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Taylor PC; Apps JFSL Synthetic methods : part (iii) Heteroatom chemistry Annual Reports Section "B" (Organic Chemistry) Volume 104 49-67, 2008
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Smith TR; Clark AJ; Napier RM; Taylor PC; Thompson AJ; Marsh A Function and stability of abscisic acid acyl hydrazone conjugates by LC-MS2 of ex vivo samples Bioconjugate Chemistry Vol.18 1355-1359, 2007
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Roengpithya C; Patterson DA; Livingston AG; Taylor PC; Irwin JL; Parrett MR Towards a continuous dynamic kinetic resolution of 1-phenylethylamine using a membrane assisted, two vessel process CHEMICAL COMMUNICATIONS 3462-3463, 2007
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Dilly SJ; Bell MJ; Clark AJ; Marsh A; Napier RM; Sergeant MJ; Thompson AJ; Taylor PC A photoimmobilisation strategy that maximises exploration of chemical space in small molecule affinity selection and target discovery CHEMICAL COMMUNICATIONS 2808-2810, 2007
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Dilly SJ; Beecham MP; Brown SP; Griffin JM; Clark AJ; Griffin CD; Marshall J; Napier RM; Taylor PC; Marsh A Novel tertiary amine oxide surfaces that resist nonspecific protein adsorption Langmuir Vol.22 8144-8150, 2006
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Dilly SJ; Carlisle SJ; Clarke AJ; Shepherd AR; Smith SC; Taylor PC; Marsh A Practical syntheses of [1,3,5]-triazine dendritic molecules on solid supports Journal of Polymer Science. Part A, Polymer Chemistry Volume 44 2248-2259, 2006
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Dilly SJ; Beecham MP; Brown SP; Griffin JM; Clark AJ; Griffin CD; Marshall J; Napier RM; Taylor PC; Marsh A Novel tertiary amine oxide surfaces that resist non-specific protein adsorption Langmuir Vol.22 8144-8150, 2006
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Clarkson GJ; Livingston AG; Muir JC; Taylor PC The absolute configuration of (+)-(E)-4-phenylbut-3-ene-2-ol Organic&Biomolecular Chemistry Volume 4 2081-2081, 2006
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