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Natalia Sergeeva

Lecturer
Member of the Colour and Polymer Science group

Contact details

Room: 1.14
Tel: +44 (0)113 3437553
Email: N.Sergeeva@leeds.ac.uk

Keywords

Biological colorants
Fluorescent dyes and organic chromophores
Chromic materials
Organic nanomaterials
Photomedicine and photodynamic therapy

Photograph of Natalia Sergeeva

Research interests

Due to their unique nature, coloured materials have found various applications in our day-to-day life including energy harvesting systems, solar protectors, UV and thermo-sensors, smart textiles, food technology, beauty & cosmetics, fashion etc. Many of these applications have been inspired by natural systems, which have been successfully isolated, re-created and synthetically improved providing a great choice of multifunctional and smart materials.

My research interests lie on the frontier of PHYSICS CHEMISTRY MOLECULAR MEDICINE and underpin the synthetic aspects and utilisation of these organic colorants with distinct optical and photophysical properties.[1] My particular interest is in functional dyes which can be used for purposes other than just colouration, for instance imaging agents with large Stokes shifts and NIR dyes, inflammation sensors, antimicrobial agents and chromic dyes which change the colour upon an external stimulus. Novel synthetic methods of these functional dyes therefore are essential to meet particular requirements to fine-tune the spectroscopic properties or generate new coloured organic materials for specific purposes.

Colorants in Healthcare [2,3]

Many of these functional dyes are based on biological molecules such as photosynthetic and respiratory pigments, betalains, flavonoids etc. which show physiological activities including anti-microbial, anti-tumour, anti-ageing, anti-inflammatory, immunosuppressive etc. This fact has been extensively used in preparation of novel therapeutics and preventive measures in healthcare.

Photodynamic therapy (PDT) is a division of photomedicine and based on three key elements light, a PDT agent (photosensitiser) and oxygen. PDT has been successfully used to treat medical conditions such as cancer, skin and vision disorders. Moreover, PDT can be used as an alternative treatment against infectious pathogens; which due to a rise in antibiotics resistance is becoming increasingly important.

Organic nanomaterials [4]

Our recent studies showed that functional dyes can also be used in preparation of stable, structurally well defined self-assembled nano-meshes. The basic idea is a use of molecular building blocks with predetermined intermolecular bonding properties. Since molecular self-assembly is based on non-covalent interactions, the stabilisation energies are usually very low. This results in conventional self-assembled structures often being unstable even at moderate temperatures. Inducing covalent reactions between the corresponding molecular components is an appealing approach in the fabrication of nanoscale structures. These nanostructures have potential applications in novel sensing, energy conversion or catalytic devices and molecular templates for directing the growth of, for example, metal clusters with interesting catalytic or magnetic properties.

Useful links

Knowledge Transfer   
MSc Programme   
   

Publications

Martin DP, Tariq A, Richards BDO, Jose G, Krasnikov SA, Kulak A, Sergeeva NN White light induced covalent modification of graphene using a phenazine dye CHEMICAL COMMUNICATIONS 53 10715-10718, 2017
DOI:10.1039/c7cc05158a

Lübben O, Krasnikov SA, Walls B, Sergeeva NN, Murphy BE, Chaika AN, Bozhko SI, Shvets IV Nanoclusters and nanolines: the effect of molybdenum oxide substrate stoichiometry on iron self-assembly Nanotechnology 28 -, 2017
DOI:10.1088/1361-6528/aa6b50
View abstract

Canas AMG, Martsinovich N, Sergeeva NN pi-Conjugated Indole Dyads with Strong Blue Emission Made Possible by Stille Cross-Coupling and Double Fischer Indole Cyclisation CHEMISTRYSELECT 2 2433-2438, 2017
DOI:10.1002/slct.201700217

Svirskiy GI, Sergeeva NN, Krasnikov SA, Vinogradov NA, Sergeeva YN, Cafolla AA, Preobrajenski AB, Vinogradov AS Electronic structure of nickel porphyrin NiP: Study by X-ray photoelectron and absorption spectroscopy Physics of the Solid State 59 368-377, 2017
DOI:10.1134/S1063783417020299
View abstract

Beard E, Ledward M, Sergeeva N Bio-based additives as renewable alternatives for polyvinylchloride formulations and application in paper coatings RSC Advances 7 31428-31432, 2017
DOI:10.1039/c7ra04995a
View abstract

Rogers L, Sergeeva NN, Paszko E, Vaz GMF, Senge MO Lead Structures for Applications in Photodynamic Therapy. 6. Temoporfin Anti-Inflammatory Conjugates to Target the Tumor Microenvironment for In Vitro PDT PLoS ONE 10 -, 2015
DOI:10.1371/journal.pone.0125372
View abstract

Ryan AA, Ebrahim MM, Petitdemange R, Vaz GM, Paszko E, Sergeeva NN, Senge MO Lead structures for applications in photodynamic therapy. 5. Synthesis and biological evaluation of water soluble phosphorus(V) 5,10,15,20-tetraalkylporphyrins for PDT. Photodiagnosis and Photodynamic Therapy 11 510-515, 2014
DOI:10.1016/j.pdpdt.2014.07.003
View abstract

Murphy BE, Krasnikov SA, Sergeeva NN, Cafolla AA, Preobrajenski AB, Chaika AN, Lübben O, Shvets IV Homolytic cleavage of molecular oxygen by manganese porphyrins supported on Ag(111). ACS Nano 8 5190-5198, 2014
DOI:10.1021/nn501240j
View abstract

Doyle CM, Cunniffe JP, Krasnikov SA, Preobrajenski AB, Li Z, Sergeeva NN, Senge MO, Cafolla AA Ni-Cu ion exchange observed for Ni(II)-porphyrins on Cu(111). Chemical Communications 50 3447-3449, 2014
DOI:10.1039/c3cc48913b
View abstract

Krasnikov SA, Lübben O, Murphy BE, Bozhko SI, Chaika AN, Sergeeva NN, Bulfin B, Shvets IV Writing with atoms: Oxygen adatoms on the MoO2/Mo(110) surface Nano Research 6 929-937, 2013
DOI:10.1007/s12274-013-0370-2
View abstract

Rogers L, Majer F, Sergeeva NN, Paszko E, Gilmer JF, Senge MO Synthesis and biological evaluation of Foscan® bile acid conjugates to target esophageal cancer cells. Bioorganic and Medicinal Chemistry Letters 23 2495-2499, 2013
DOI:10.1016/j.bmcl.2013.03.040
View abstract

Bozhko SI, Krasnikov SA, Lübben O, Murphy BE, Radican K, Semenov VN, Wu HC, Levchenko EA, Chaika AN, Sergeeva NN, Shvets IV Correlation between charge-transfer and rotation of C60 on WO2/W(110). Nanoscale 5 3380-3386, 2013
DOI:10.1039/c3nr34087b
View abstract

Beggan JP, Krasnikov SA, Sergeeva NN, Senge MO, Cafolla AA Control of the axial coordination of a surface-confined manganese (III) porphyrin complex. Nanotechnology 23 235606-, 2012
DOI:10.1088/0957-4484/23/23/235606
View abstract

Berner NC, Sergeeva YN, Sergeeva NN, Senge MO, Cafolla AA, Mcgovern IT Adsorption of 5,10,15,20-tetrakis (4-bromophenyl)porphyrin on germanium(001) Physica Status Solidi (C) Current Topics in Solid State Physics 9 1404-1407, 2012
DOI:10.1002/pssc.201100650
View abstract

Murphy BE, Krasnikov SA, Cafolla AA, Sergeeva NN, Vinogradov NA, Beggan JP, Lübben O, Senge MO, Shvets IV Growth and ordering of Ni(II) diphenylporphyrin monolayers on Ag(111) and Ag/Si(111) studied by STM and LEED. J Phys Condens Matter 24 045005-, 2012
DOI:10.1088/0953-8984/24/4/045005
View abstract

Sergeeva NN, Donnier-Marechal M, Vaz G, Davies AM, Senge MO Synthesis and evaluation of the europium(III) and zinc(II) complexes as luminescent bioprobes in high content cell-imaging analysis. J Inorg Biochem 105 1589-1595, 2011
DOI:10.1016/j.jinorgbio.2011.08.023
View abstract

Doyle CM, Krasnikov SA, Sergeeva NN, Preobrajenski AB, Vinogradov NA, Sergeeva YN, Senge MO, Cafolla AA Evidence for the formation of an intermediate complex in the direct metalation of tetra(4-bromophenyl)-porphyrin on the Cu(111) surface. Chem Commun (Camb) 47 12134-12136, 2011
DOI:10.1039/c1cc15241f
View abstract

Sergeeva NN, Donnier-Marechal M, Vaz GM, Davies AM, Senge MO Simple but powerful: phenanthroline-based small molecules for cellular imaging and cancer screening. Bioorg Med Chem Lett 21 4385-4388, 2011
DOI:10.1016/j.bmcl.2011.06.051
View abstract

Bakar MA, Sergeeva NN, Juillard T, Senge MO Synthesis of ferrocenyl porphyrins via suzuki coupling and their photophysical properties Organometallics 30 3225-3228, 2011
DOI:10.1021/om200137p
View abstract

Krasnikov SA, Doyle CM, Sergeeva NN, Preobrajenski AB, Vinogradov NA, Sergeeva YN, Zakharov AA, Senge MO, Cafolla AA Formation of Extended Covalently Bonded Ni Porphyrin Networks on the Au(111) Surface Nano Research 4 376-384, 2011
DOI:10.1007/s12274-010-0092-7
View abstract

Krasnikov SA, Sergeeva NN, Sergeeva YN, Senge MO, Cafolla AA Self-assembled rows of Ni porphyrin dimers on the Ag(111) surface. Phys Chem Chem Phys 12 6666-6671, 2010
DOI:10.1039/b921656a
View abstract

Sergeeva NN, Senge MO, Ryan A Organometallic C-C Coupling Reactions for Porphyrins HANDBOOK OF PORPHYRIN SCIENCE WITH APPLICATIONS TO CHEMISTRY, PHYSICS, MATERIALS SCIENCE, ENGINEERING, BIOLOGY AND MEDICINE, VOL 3 3 325-365, 2010

Sergeeva NN, Scala A, Bakar MA, O'Riordan G, O'Brien J, Grassi G, Senge MO Synthesis of stannyl porphyrins and porphyrin dimers via stille coupling and their (119)Sn NMR and fluorescence properties. J Org Chem 74 7140-7147, 2009
DOI:10.1021/jo901535c
View abstract

Krasnikov SA, Beggan JP, Sergeeva NN, Senge MO, Cafolla AA Ni(II) porphine nanolines grown on a Ag(111) surface at room temperature. Nanotechnology 20 135301-, 2009
DOI:10.1088/0957-4484/20/13/135301
View abstract

Sergeeva NN, Bakar MB, Senge MO Synthesis, transformations, and comparative studies of porphyryl acrylic acids and their homologues. J Org Chem 74 1488-1497, 2009
DOI:10.1021/jo8021764
View abstract

Sergeeva NN, Pablo VL, Senge MO Synthesis of porphyryl boronates with (un)saturated side-chains Journal of Organometallic Chemistry 693 2637-2640, 2008
DOI:10.1016/j.jorganchem.2008.05.006
View abstract

Krasnikov SA, Sergeeva NN, Brzhezinskaya MM, Preobrajenski AB, Sergeeva YN, Vinogradov NA, Cafolla AA, Senge MO, Vinogradov AS An x-ray absorption and photoemission study of the electronic structure of Ni porphyrins and Ni N-confused porphyrin. J Phys Condens Matter 20 235207-, 2008
DOI:10.1088/0953-8984/20/23/235207
View abstract

Beggan JP, Krasnikov SA, Sergeeva NN, Senge MO, Cafolla AA Self-assembly of Ni(II) porphine molecules on the Ag/Si(111)-(√3 × √3)R30° surface studied by STM/STS and LEED Journal of Physics Condensed Matter 20 -, 2008
DOI:10.1088/0953-8984/20/01/015003
View abstract

Sergeeva NN, Shaker YM, Finnigan EM, McCabe T, Senge MO Synthesis of hydroporphyrins based on comparative studies of palladium-catalyzed and non-catalyzed approaches Tetrahedron 63 12454-12464, 2007
DOI:10.1016/j.tet.2007.09.030
View abstract

Horn S, Sergeeva NN, Senge MO Conversion of Ni(II)-allylporphyrins to alpha,beta-unsaturated formylporphyrins via a nickel-promoted reaction. J Org Chem 72 5414-5417, 2007
DOI:10.1021/jo070550g
View abstract

Krasnikov SA, Preobrajenski AB, Sergeeva NN, Brzhezinskaya MM, Nesterov MA, Cafolla AA, Senge MO, Vinogradov AS Electronic structure of Ni(II) porphyrins and phthalocyanine studied by soft X-ray absorption spectroscopy Chemical Physics 332 318-324, 2007
DOI:10.1016/j.chemphys.2006.12.015
View abstract

Senge MO, Sergeeva NN Metamorphosis of tetrapyrrole macrocycles. Angew Chem Int Ed Engl 45 7492-7495, 2006
DOI:10.1002/anie.200603249

Sergeeva NN, Senge MO Palladium-catalyzed reactions for the synthesis of chlorins and 5,10-porphodimethenes Tetrahedron Letters 47 6169-6172, 2006
DOI:10.1016/j.tetlet.2006.06.166
View abstract

Sergeeva NN, Golubev AS, Hennig L, Burger K Synthesis ofβ-amino and β-hydroxy phosphonates Synthesis 915-919, 2003
View abstract

Golubev AS, Sergeeva NN, Hennig L, Kolomiets AF, Burger K Carbonyl-yne reactions of 3,3,3-trifluoropyruvates Tetrahedron 59 1389-1394, 2003
DOI:10.1016/S0040-4020(03)00084-X
View abstract

Sergeeva NN, Golubev AS, Hennig L, Burger K Efficient syntheses ofω-trifluoromethyl substituted ω-amino acids Synthesis 2579-2584, 2002
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Sergeeva NN, Golubev AS, Burger K Synthesis of partially fluorinatedβ-amino acids via Morita-Baylis-Hillman reaction Synthesis 281-285, 2001
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Sergeeva NN, Golubev AS, Hennig L, Findeisen M, Paetzold E, Oehme G, Burger K An improved approach to trifluoromethyl substituted Morita-Baylis-Hillman adduct: Fluorinated dehydro-β-amino acids Journal of Fluorine Chemistry 111 41-44, 2001
DOI:10.1016/S0022-1139(01)00434-1
View abstract