School of Chemistry

Adam Nelson

Professor of Chemical Biology
Research section: Organic Chemistry

Contact details

Keywords

Synthesis of biologically active compounds
Diversity-oriented synthesis
Chemical Genetics
Chemical Biology
Directed evolution of enzymes for use in organic synthesis

Research interests

We are interested in synthetic organic chemistry and its application to biological problems. We focus on the development of new strategies and methods for asymmetric and stereoselective synthesis, which we apply in the synthesis of biologically active molecules and natural products.

Synthesis is an immensely powerful tool in Chemical Biology, which we exploit in a wide range of applications; from the evolution of new enzymes for synthetic chemistry, to the discovery of new modulators of protein function. Browse our research pages to find out more about what we do!

Useful links

Enter Nelson group web site   
   
   

Selected publications

D. Morton, S. Leach, C. Cordier, S. Warriner and A. Nelson, Synthesis of natural product-like molecules with over eighty distinct skeletons, Angew. Chem., Int. Ed. 2009, 47, 104

H. K. Bone, T. Damiano, S. Bartlett, A. Perry, J. Letchford, A. Nelson and M. J. Welham, Involvement of glycogen synthase kinase-3 in regulation of murine embryonic stem cell self-renewal revealed by a series of bisindolylmaleimides, Chem. Biol. 2009, 16, 15-27.

G. J. Williams, T. Woodhall, L. Farnsworth, A. Nelson and A. Berry, Creation of a Pair of Stereochemically Complementary Biocatalysts, J. Am. Chem. Soc. 2006, 128, 16238-16247.

C.Crawford, A.Nelson and I.Patel, Development of an Approach to the Synthesis of the ABC Ring System of Hemibrevetoxin B, Org. Lett. 2006, 8, 4231-4234