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Adam Nelson

Professor of Chemical Biology
Member of the Chemical Biology and Medicinal Chemistry group

Contact details

Room: G30
Tel: +44 (0)113 3436502
Email: A.S.Nelson@leeds.ac.uk

Keywords

Synthesis of biologically active compounds
Diversity-oriented synthesis
Chemical Genetics
Chemical Biology
Directed evolution of enzymes for use in organic synthesis

Photograph of Adam Nelson

Research interests

We are interested in synthetic organic chemistry and its application to biological problems. We focus on the development of new strategies and methods for asymmetric and stereoselective synthesis, which we apply in the synthesis of biologically active molecules and natural products.

Synthesis is an immensely powerful tool in Chemical Biology, which we exploit in a wide range of applications; from the evolution of new enzymes for synthetic chemistry, to the discovery of new modulators of protein function. Browse our research pages to find out more about what we do!

Useful links

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Publications

Colomer I, Empson CJ, Craven P, Owen Z, Doveston RG, Churcher I, Marsden SP, Nelson A A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open-access computational tool. Chemical communications (Cambridge, England) -, 2016
View abstract

Burslem GM, Kyle HF, Breeze AL, Edwards TA, Nelson A, Warriner SL, Wilson AJ Towards "bionic" proteins: Replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics Chemical Communications 52 5421-5424, 2016
DOI:10.1039/c6cc01812b
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Burslem GM, Kyle HF, Prabhakaran P, Breeze AL, Edwards TA, Warriner SL, Nelson A, Wilson AJ Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups Organic and Biomolecular Chemistry 14 3782-3786, 2016
DOI:10.1039/c6ob00078a
View abstract

Howard JK, Müller M, Berry A, Nelson A An Enantio- and Diastereoselective Chemoenzymatic Synthesis ofα-Fluoro β-Hydroxy Carboxylic Esters Angewandte Chemie - International Edition -, 2016
DOI:10.1002/anie.201602852
View abstract

Karageorgis G, Dow M, Aimon A, Warriner S, Nelson A Activity-Directed Synthesis with Intermolecular Reactions: Development of a Fragment into a Range of Androgen Receptor Agonists Angewandte Chemie - International Edition 54 13538-13544, 2015
DOI:10.1002/anie.201506944
View abstract

Karawajczyk A, Giordanetto F, Benningshof J, Hamza D, Kalliokoski T, Pouwer K, Morgentin R, Nelson A, Müller G, Piechot A, Tzalis D Expansion of chemical space for collaborative lead generation and drug discovery: The European Lead Factory Perspective Drug Discovery Today 20 1310-1316, 2015
DOI:10.1016/j.drudis.2015.09.009
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Karageorgis G, Dow M, Aimon A, Warriner S, Nelson A Frontispiece: Activity-Directed Synthesis with Intermolecular Reactions: Development of a Fragment into a Range of Androgen Receptor Agonists. Angewandte Chemie (International ed. in English) 54 -, 2015
DOI:10.1002/anie.201584661
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Kallus C, Hüser J, Jones PS, Nelson A The European Lead Factory In Small Molecule Medicinal Chemistry: Strategies and Technologies , 2015
DOI:10.1002/9781118771723.ch2
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Foley DJ, Doveston RG, Churcher I, Nelson A, Marsden SP A systematic approach to diverse, lead-like scaffolds fromα,α-disubstituted amino acids Chemical Communications 51 11174-11177, 2015
DOI:10.1039/c5cc03002a
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Kyle HF, Wickson KF, Stott J, Burslem GM, Breeze AL, Tiede C, Tomlinson DC, Warriner SL, Nelson A, Wilson AJ, Edwards TA Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies Molecular BioSystems 11 2738-2749, 2015
DOI:10.1039/c5mb00284b
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Craven P, Aimon A, Dow M, Fleury-Bregeot N, Guilleux R, Morgentin R, Roche D, Kalliokoski T, Foster R, Marsden SP, Nelson A Design, synthesis and decoration of molecular scaffolds for exploitation in the production of alkaloid-like libraries Bioorganic and Medicinal Chemistry 23 2629-2635, 2015
DOI:10.1016/j.bmc.2014.12.048
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Colomer I, Adeniji O, Burslem GM, Craven P, Rasmussen MO, Willaume A, Kalliokoski T, Foster R, Marsden SP, Nelson A Aminomethylhydroxylation of alkenes: Exploitation in the synthesis of scaffolds for small molecule libraries Bioorganic and Medicinal Chemistry 23 2736-2740, 2015
DOI:10.1016/j.bmc.2015.01.058
View abstract

Nelson A, Roche D Innovative approaches to the design and synthesis of small molecule libraries Bioorganic and Medicinal Chemistry 23 2613-, 2015
DOI:10.1016/j.bmc.2015.02.046

Firth JD, Zhang R, Morgentin R, Guilleux R, Kalliokoski T, Warriner S, Foster R, Marsden SP, Nelson A Exploitation of the Ugi-Joullié Reaction in the Synthesis of Libraries of Drug-Like Bicyclic Hydantoins Synthesis (Germany) 47 2391-2406, 2015
DOI:10.1055/s-0034-1378704
View abstract

Windle C, Nelson A, Pearson A, Berry A Exploiting Non-Canonical Amino Acids to Alter Enzyme Substrate Specificity, 2015

Doveston RG, Tosatti P, Dow M, Foley DJ, Li HY, Campbell AJ, House D, Churcher I, Marsden SP, Nelson A A unified lead-oriented synthesis of over fifty molecular scaffolds Organic and Biomolecular Chemistry 13 859-865, 2015
DOI:10.1039/c4ob02287d
View abstract

Stockwell J, Daniels AD, Windle CL, Harman TA, Woodhall T, Lebl T, Trinh CH, Mulholland K, Pearson AR, Berry A, Nelson A Evaluation of fluoropyruvate as nucleophile in reactions catalysed by N-acetyl neuraminic acid lyase variants: Scope, limitations and stereoselectivity Organic and Biomolecular Chemistry 14 105-112, 2015
DOI:10.1039/c5ob02037a
View abstract

Karageorgis G, Warriner S, Nelson A Efficient discovery of bioactive scaffolds by activity-directed synthesis. Nature Chemistry 6 872-876, 2014
DOI:10.1038/nchem.2034
View abstract

Foley DJ, Nelson AS, Marsden SP Realising lead-oriented synthesis (LOS): A powerful approach to diverse, lead-like, small molecule scaffolds, 2014

Li HY, Horn J, Campbell A, House D, Nelson A, Marsden SP A convergent rhodium-catalysed asymmetric synthesis of tetrahydroquinolines. Chemical Communications 10222-10224, 2014
DOI:10.1039/c4cc04940c
View abstract

Doveston R, Marsden S, Nelson A Towards the realisation of lead-oriented synthesis. Drug Discov Today 19 813-819, 2014
DOI:10.1016/j.drudis.2013.11.006
View abstract

Burslem GM, Kyle HF, Breeze AL, Edwards TA, Nelson A, Warriner SL, Wilson AJ Small-molecule proteomimetic inhibitors of the HIF-1α-p300 protein-protein interaction. Chembiochem 15 1083-1087, 2014
DOI:10.1002/cbic.201400009
View abstract

Daniels AD, Campeotto I, van der Kamp MW, Bolt AH, Trinh CH, Phillips SE, Pearson AR, Nelson A, Mulholland AJ, Berry A Reaction mechanism of N-acetylneuraminic acid lyase revealed by a combination of crystallography, QM/MM simulation, and mutagenesis. ACS Chem Biol 9 1025-1032, 2014
DOI:10.1021/cb500067z
View abstract

Windle CL, Müller M, Nelson A, Berry A Engineering aldolases as biocatalysts Current Opinion in Chemical Biology 19 25-33, 2014
DOI:10.1016/j.cbpa.2013.12.010
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James T, Maclellan P, Burslem GM, Simpson I, Grant JA, Warriner S, Sridharan V, Nelson A A modular lead-oriented synthesis of diverse piperazine, 1,4-diazepane and 1,5-diazocane scaffolds. Organic and Biomolecular Chemistry 12 2584-2591, 2014
DOI:10.1039/c3ob42512f
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Martin HL, Adams M, Higgins J, Bond J, Morrison EE, Bell SM, Warriner S, Nelson A, Tomlinson DC High-content, high-throughput screening for the identification of cytotoxic compounds based on cell morphology and cell proliferation markers. PLoS One 9 e88338-, 2014
DOI:10.1371/journal.pone.0088338
View abstract

Doveston R, Marsden S, Nelson A Towards the realisation of lead-oriented synthesis Drug Discovery Today 19 813-819, 2014
DOI:10.1016/j.drudis.2013.11.006
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Fisher M, Basak R, Kalverda AP, Fishwick CW, Bruce Turnbull W, Nelson A Discovery of novel FabF ligands inspired by platensimycin by integrating structure-based design with diversity-oriented synthetic accessibility. Organic and Biomolecular Chemistry -, 2013
DOI:10.1039/c3ob41975d
View abstract

James T, Simpson I, Grant JA, Sridharan V, Nelson A Modular, Gold-Catalyzed Approach to the Synthesis of Lead-like Piperazine Scaffolds. Organic Letters 15 6094-6097, 2013
DOI:10.1021/ol402988s
View abstract

Maurya SK, Dow M, Warriner S, Nelson A Synthesis of skeletally diverse alkaloid-like molecules: Exploitation of metathesis substrates assembled from triplets of building blocks Beilstein Journal of Organic Chemistry 9 775-785, 2013
DOI:10.3762/bjoc.9.88
View abstract

Timms N, Windle CL, Polyakova A, Ault JR, Trinh CH, Pearson AR, Nelson A, Berry A Structural insights into the recovery of aldolase activity in N-acetylneuraminic acid lyase by replacement of the catalytically active lysine withγ-thialysine by using a chemical mutagenesis strategy. Chembiochem 14 474-481, 2013
DOI:10.1002/cbic.201200714
View abstract

MacLellan P, Nelson A A conceptual framework for analysing and planning synthetic approaches to diverse lead-like scaffolds. Chemical Communications 49 2383-2393, 2013
DOI:10.1039/c2cc38184b
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Kinnell A, Harman T, Bingham M, Berry A, Nelson A Development of an organo- and enzyme-catalysed one-pot, sequential three-component reaction Tetrahedron 68 7719-7722, 2012
DOI:10.1016/j.tet.2012.02.010
View abstract

Timms N, Daniels AD, Berry A, Nelson A 7.3 Directed Evolution and (Semi-) Rational Design Strategies for the Creation of Synthetically useful, Stereoselective Biocatalysts, 2012
DOI:10.1016/B978-0-08-095167-6.00703-5
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Tosatti P, Nelson A, Marsden SP Recent advances and applications of iridium-catalysed asymmetric allylic substitution. Org Biomol Chem 10 3147-3163, 2012
DOI:10.1039/c2ob07086c
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Li HY, Horn J, Shearer RJ, Marsden SP, Nelson A, Campbell AJ, House D, Weingarten GG Rhodium-catalyzed conjugate addition with functionized boronate: Divergent access to various building blocks with lead-like molecular properties, 2012

Dow M, Fisher M, James T, Marchetti F, Nelson A Towards the systematic exploration of chemical space. Org Biomol Chem 10 17-28, 2012
DOI:10.1039/c1ob06098h
View abstract

Joce C, White R, Stockley PG, Warriner S, Turnbull WB, Nelson A Design, synthesis and in vitro evaluation of novel bivalent S-adenosylmethionine analogues. Bioorg Med Chem Lett 22 278-284, 2012
DOI:10.1016/j.bmcl.2011.11.017
View abstract

Kinnell A, Harman T, Bingham M, Berry A, Nelson A Development of an organo- and enzyme-catalysed one-pot, sequential three-component reaction Tetrahedron -, 2012

Bone HK, Nelson AS, Goldring CE, Tosh D, Welham MJ A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3 Development 138 1992-2000, 2011
DOI:10.1242/jcs.081679
View abstract

Tosatti P, Campbell AJ, House D, Nelson A, Marsden SP Catalyst control in sequential asymmetric allylic substitution: stereodivergent access to N,N-diprotected unnatural amino acids. J Org Chem 76 5495-5501, 2011
DOI:10.1021/jo200720c
View abstract

Bone HK, Nelson AS, Goldring CE, Tosh D, Welham MJ A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3 J CELL SCI 124 1992-2000, 2011
DOI:10.1242/jcs.081679

Murrison S, Maurya SK, Einzinger C, McKeever-Abbas B, Warriner S, Nelson A Synthesis of Skeletally Diverse Alkaloid-Like Small Molecules EUR J ORG CHEM 2354-2359, 2011
DOI:10.1002/ejoc.201100116

Tosatti P, Campbell AJ, House D, Nelson A, Marsden SP Iridium-catalyzed asymmetric allylic amination with polar amines: Access to building blocks with lead-like molecular properties, 2011

Tosatti P, Campbell AJ, House D, Nelson A, Marsden SP Iridium-catalyzed asymmetric allylic amination with polar amines: Access to building blocks with lead-like molecular properties, 2011

Tosatti P, Campbell AJ, House D, Nelson A, Marsden SP Catalyst control in sequential asymmetric allylic substitution: Stereodivergent access to N,N-diprotected unnatural amino acids, 2011

Tosatti P, Campbell AJ, House D, Nelson A, Marsden SP Catalyst control in sequential asymmetric allylic substitution: Stereodivergent access to N,N-diprotected unnatural amino acids, 2011

Tosatti P, Horn J, Campbell AJ, House D, Nelson A, Marsden SP Iridium-Catalyzed Asymmetric Allylic Amination with Polar Amines: Access to Building Blocks with Lead-Like Molecular Properties ADV SYNTH CATAL 352 3153-3157, 2010
DOI:10.1002/adsc.201000721

Campeotto I, Bolt AH, Harman TA, Dennis C, Trinh CH, Phillips SE, Nelson A, Pearson AR, Berry A Structural insights into substrate specificity in variants of N-acetylneuraminic Acid lyase produced by directed evolution. J Mol Biol 404 56-69, 2010
DOI:10.1016/j.jmb.2010.08.008
View abstract

O'Leary-Steele C, Pedersen PJ, James T, Lanyon-Hogg T, Leach S, Hayes J, Nelson A Synthesis of small molecules with high scaffold diversity: exploitation of metathesis cascades in combination with inter- and intramolecular Diels-Alder reactions. Chemistry 16 9563-9571, 2010
DOI:10.1002/chem.201000707
View abstract

Horsfall LE, Nelson A, Berry A Identification and characterization of important residues in the catalytic mechanism of CMP-Neu5Ac synthetase from Neisseria meningitidis. FEBS J 277 2779-2790, 2010
DOI:10.1111/j.1742-4658.2010.07696.x
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Campeotto I, Carr SB, Trinh CH, Nelson AS, Berry A, Phillips SEV, Pearson AR Structure of an Escherichia coli N-acetyl-D-neuraminic acid lyase mutant, E192N, in complex with pyruvate at 1.45 angstrom resolution ACTA CRYSTALLOGR F 65 1088-1090, 2009
DOI:10.1107/S1744309109037403

Horn J, Li HY, Marsden SP, Nelson A, Shearer RJ, Campbell AJ, House D, Weingarten GG Convergent synthesis of dihydroquinolones from o-aminoarylboronates TETRAHEDRON 65 9002-9007, 2009
DOI:10.1016/j.tet.2009.06.103

Nelson A, Bone H, Damiano M, Welham M, Bartlett S, Perry A, Cordier CJ, Warriner S, Leach SG, Morton D, Letchford J Exploring biologically-relevant chemical space with macrocyclic ligands ABSTR PAP AM CHEM S 238 -, 2009

Nelson A, Bone H, Damiano M, Welham M, Bartlett S, Perry A, Cordier CJ, Warriner S, Leach SG, Morton D, Letchford J Exploring biologically-relevant chemical space with macrocyclic ligands ABSTR PAP AM CHEM S 238 -, 2009

Tosatti P, Marsden SP, Nelson AS, House D, Weingarten GG ORGN 431-Iterative cross-metathesis and Cu-catalyzed asymmetric allylic substitution: Matched and mismatched effects ABSTR PAP AM CHEM S 237 -, 2009

Tosatti P, Marsden SP, Nelson AS, House D, Weingarten GG ORGN 431-Iterative cross-metathesis and Cu-catalyzed asymmetric allylic substitution: Matched and mismatched effects ABSTR PAP AM CHEM S 237 -, 2009

O'Leary-Steele C, Cordier C, Hayes J, Warriner S, Nelson A A fluorous-tagged "safety catch" linker for preparing heterocycles by ring-closing metathesis. Org Lett 11 915-918, 2009
DOI:10.1021/ol802848j
View abstract

Bone HK, Damiano T, Bartlett S, Perry A, Letchford J, Ripoll YS, Nelson AS, Welham MJ Involvement of GSK-3 in Regulation of Murine Embryonic Stem Cell Self-Renewal Revealed by a Series of Bisindolylmaleimides CHEM BIOL 16 15-27, 2009
DOI:10.1016/j.chembiol.2008.11.003

Murrison S, Glowacki D, Einzinger C, Titchmarsh J, Bartlett S, McKeever-Abbas B, Warriner S, Nelson A Remarkably slow rotation about a single bond between an sp(3)-hybridised carbon atom and an aromatic ring without ortho substituents. Chemistry 15 2185-2189, 2009
DOI:10.1002/chem.200802127
View abstract

Joce C, Caryl J, Stockley PG, Warriner S, Nelson A Identification of stable S-adenosylmethionine (SAM) analogues derivatised with bioorthogonal tags: effect of ligands on the affinity of the E. coli methionine repressor, MetJ, for its operator DNA ORG BIOMOL CHEM 7 635-638, 2009
DOI:10.1039/b816495a

Morton D, Leach S, Cordier C, Warriner S, Nelson A Synthesis of Natural-Product-Like Molecules with Over Eighty Distinct Scaffolds ANGEW CHEM INT EDIT 48 104-109, 2009
DOI:10.1002/anie.200804486

Horn J, Marsden SP, Nelson A, House D, Weingarten GG Convergent, regiospecific synthesis of quinolines from o-aminophenylboronates. Org Lett 10 4117-4120, 2008
DOI:10.1021/ol8016726
View abstract

Murrison SL, Nelson AS, Warriner S, McKeever-Abbas B ORGN 668-Diversity-oriented synthesis of polycyclic alkaloid-like libraries., 2008

Murrison SL, Nelson AS, Warriner S, McKeever-Abbas B ORGN 668-Diversity-oriented synthesis of polycyclic alkaloid-like libraries., 2008

Cordier C, Morton D, Murrison S, Nelson A, O'Leary-Steele C Natural products as an inspiration in the diversity-oriented synthesis of bioactive compound libraries NAT PROD REP 25 719-737, 2008
DOI:10.1039/b706296f

Leach SG, Cordier CJ, Morton D, McKiernan GJ, Warriner S, Nelson A A fluorous-tagged linker from which small molecules are released by ring-closing metathesis J ORG CHEM 73 2753-2759, 2008
DOI:10.1021/jo7026273

Bolt AH, Berry A, Nelson AS Directed evolution of aldolases for exploitation in synthetic organic chemistry Archives of Biochemistry and Biophysics -, 2008
DOI:10.1016/j.abb.2008.01.005

Cordier C, Morton D, Leach S, Woodhall T, O'Leary-Steele C, Warriner S, Nelson A An efficient method for synthesising unsymmetrical silaketals: substrates for ring-closing, including macrocycle-closing, metathesis ORG BIOMOL CHEM 6 1734-1737, 2008
DOI:10.1039/b804769n

Hodgson R, Kennedy A, Nelson A, Perry A Synthesis of 3-sulfonyloxypyridines: Oxidative ring expansion of alpha-furylsulfonamides and N ->O sulfonyl transfer SYNLETT 1043-1046, 2007
DOI:10.1055/s-2007-973875

Storm MP, Bone HK, Beck CG, Bourillot PY, Schreiber V, Damiano T, Nelson A, Savatier P, Welham MJ Regulation of nanog expression by phosphoinositide 3-kinase-dependent signaling in murine embryonic stem cells J BIOL CHEM 282 6265-6273, 2007
DOI:10.1074/jbc.M610906200

Ironmonger A, Whittaker BP, Baron AJ, Clique B, Adams CJ, Ashcroft AE, Stockley PG, Nelson AS Scanning conformational space with a library of stereo- and regiochemically diverse aminoglycoside derivatives: The discovery of new ligands for RNA hairpin sequences Organic&Biomolecular Chemistry 1081-1086, 2007

Cordier C, Leach SG, Nelson AS 1,3-Dioxetanes and 1,3-dioxolanes In Science of Synthesis , 2007

Damiano T, Morton D, Nelson A Photochemical transformations of pyridinium salts: mechanistic studies and applications in synthesis ORG BIOMOL CHEM 5 2735-2752, 2007
DOI:10.1039/b706244n

Dodd K, Morton D, Worden SM, Narquizian R, Nelson AS Desymmetrisation of a Centrosymmetric Molecule by Carbon-Carbon Bond Formation: Asymmetric Aldol Reactions of a Centrosymmetric Dialdehyde Chemistry a European journal 13 -, 2007

Williams GJ, Woodhall T, Farnsworth LM, Nelson AS, Berry A Creation of a Pair of Stereochemically Complementary Biocatalysts Journal of the American Chemical Society 128 16238-16247, 2006
DOI:10.1021/ja065233q

Crawford C, Nelson A, Patel I Development of an approach to the synthesis of the ABC ring system of Hemibrevetoxin B ORG LETT 8 4231-4234, 2006
DOI:10.1021/ol0614323

Crawford C, Nelson A, Patel I Development of an approach to the synthesis of the ABC ring system of Hemibrevetoxin B ORG LETT 8 4231-4234, 2006
DOI:10.1021/ol0614323

Cordier CJ, Nelson AS ORGN 236-Diversity-oriented synthesis of natural product-like libraries ABSTR PAP AM CHEM S 232 -, 2006

Cordier CJ, Nelson AS ORGN 236-Diversity-oriented synthesis of natural product-like libraries ABSTR PAP AM CHEM S 232 -, 2006

Leach SG, Nelson AS ORGN 235-Combinatorial synthesis of alkaloid libraries ABSTR PAP AM CHEM S 232 -, 2006

Leach SG, Nelson AS ORGN 235-Combinatorial synthesis of alkaloid libraries ABSTR PAP AM CHEM S 232 -, 2006

Anstiss M, Nelson AS Catalytic and stoichiometric approaches to the desymmetrisation of centrosymmetric piperazines by enantioselective acylation: A total synthesis of Dragmacidin A Organic&Biomolecular Chemistry 4 4135-4143, 2006

Bullock AN, Debreczeni JE, Fedorov OY, Nelson A, Marsden BD, Knapp S Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in Moloney murine leukemia virus (PIM-1) kinase J MED CHEM 48 7604-7614, 2005
DOI:10.1021/jm0504858

Barrett S, Bartlett S, Bolt A, Ironmonger A, Joce C, Nelson A, Woodhall T Configurational stability of bisindolylmaleimide cyclophanes: From conformers to the first configurationally stable, atropisomeric bisindolylmaleimides CHEM-EUR J 11 6277-6285, 2005
DOI:10.1002/chem.200500520

Bartlett SJ, Beddard GS, Jackson RM, Kayser V, Kilner CA, Leach AR, Nelson AS, Oledzki P, Parker PR, Reid GD, Warriner SL Comparison of the ATP Binding Sites of Protein Kinases Using Conformationally Diverse Bisindolylmaleimides Journal of the American Chemical Society 127 11699-11708, 2005
DOI:10.1021/ja050576u

Ironmonger A, Stockley P, Nelson A Asymmetric double ring-opening of a C-2h-symmetric bis-epoxide: improved enantiomeric excess of the product through enantioselective desymmetrisation and 'proof-reading' steps ORG BIOMOL CHEM 3 2350-2353, 2005
DOI:10.1039/b504972e

Woodhall T, Williams G, Berry A, Nelson A Synthesis of screening substrates for the directed evolution of sialic acid aldolase: towards tailored enzymes for the preparation of influenza A sialidase inhibitor analogues. Org Biomol Chem 3 1795-1800, 2005
DOI:10.1039/b501503k
View abstract

Williams GJ, Woodhall T, Nelson A, Berry A Structure-guided saturation mutagenesis of N-acetylneuraminic acid lyase for the synthesis of sialic acid mimetics. Protein Eng Des Sel 18 239-246, 2005
DOI:10.1093/protein/gzi027
View abstract

Woodhall T, Williams G, Berry A, Nelson AS Creation of a Tailored Aldolase for the Parallel Synthesis of Sialic Acid Mimetics Angewandte Chemie - International Edition 44 2109-2112, 2005
DOI:10.1002/anie.200462733

Nelson AS, Perry A, Kennedy A Methods for the synthesis of polyhydroxylated piperidines by diastereoselective dihydroxylation: Exploitation in the two-directional synthesis of aza-C-linked disaccharide derivatives Beilstein Journal of Organic Chemistry 1 -, 2005

Nelson AS, Cordier C Reaching the target: small molecules aim to probe barrier quality ChemBioChem 6 1953-1955, 2005
DOI:10.1002/cbic.200500250

Nelson AS, Perry A, Kennedy A A General, two-directional synthesis of aza-(1 to 1')-C-disaccharide mimetics Chemical Communications 1646-1648, 2005

Clique B, Ironmonger A, Whittaker BP, Colley J, Titchmarsh J, Stockley PG, Nelson AS Synthesis of a library of stereo- and regiochemically diverse aminoglycoside derivatives Organic&Biomolecular Chemistry 3 2776-2785, 2005
DOI:10.1039/b505865a
View abstract

Kennedy A, Nelson A, Perry A A general, two-directional approach to aza-C-(1 ->1)-linked disaccharide mimetics CHEM COMMUN 1646-1648, 2005
DOI:10.1039/b417899h

Williams GJ, Nelson AS, Berry A Directed evolution of enzymes for biocatalysis and the life sciences Cellular and Molecular Life Sciences 61 3034-3046, 2004

Nelson AS The development of strategies and methods for the synthesis of biologically active compounds New Journal of Chemistry 28 771-776, 2004
DOI:10.1039/b316649j

Bartlett S, Nelson A Towards configurationally stable bisindolylmaleimide cyclophanes: potential tools for investigating protein kinase function CHEM COMMUN 1112-1113, 2004
DOI:10.1039/b400078a

Bartlett S, Nelson A Towards configurationally stable bisindolylmaleimide cyclophanes: potential tools for investigating protein kinase function. Chemical communications (Cambridge, England) 1112-1113, 2004
View abstract

Kennedy A, Nelson AS, Perry A Highly diastereoselective addition to ketone enolates to N-sulfinyl imines: Asymmetric synthesis of syn- and anti-1,2-amino alcohol derivatives Synlett 967-970, 2004

Hodgson R, Nelson A A two-directional synthesis of the C-58-C-71 fragment of palytoxin ORG BIOMOL CHEM 2 373-386, 2004
DOI:10.1039/b307950c

Nelson AS, Hodgson RD A two-directional synthesis of the C58-C71fragment of palytoxin Organic&Biomolecular Chemistry 2 -, 2004

Bartlett S, Nelson A Evaluation of alternative approaches for the synthesis of macrocyclic bisindolylmaleimides ORG BIOMOL CHEM 2 2874-2883, 2004
DOI:10.1039/b405010j

Holland JM, Lewis M, Nelson AS Desymmetrization of a Centrosymmetric Diepoxide: Efficient Synthesis of a Key Intermediate in a Total Synthesis of Hemibrevetoxin B The Journal of Organic Chemistry (Washington) 68 747-753, 2003

Anstiss M, Holland JM, Nelson AS, Titchmarsh J Beyond Breaking the Mirror Plane: The Desymmetrisation of Centro-symmetric Molecules as an Efficient Strategy for Asymmetric Synthesis Synlett 8 1213-1220, 2003

Bartlett SJ, Hodgson RD, Holland JM, Jones M, Kilner CA, Nelson AS, Warriner SL Exploiting predisposition in the stereoselective synthesis of mono-, bi- and tetracyclic oxygen heterocycles: Equilibration between, and trapping of, alternative di- and tetraacetals Organic&Biomolecular Chemistry 1 2393-2402, 2003
DOI:10.1039/b303089j

Carter C, Fletcher SJ, Nelson AS Towards phase-transfer catalysts with a chiral anion: inducing asymmetry in the reactions of cations Tetrahedron: Asymmetry 14 1995-2004, 2003
DOI:10.1016/S0957-4166(03)00367-7

Williams GJ, Domann S, Nelson AS, Berry A Modifying the stereochemistry of an enzyme-catalyzed reaction by directed evolution Proceedings of the National Academy of Sciences of the United States of America 100 3143-3148, 2003
DOI:10.1073/pnas.0635924100

Suryanti V, Nelson AS, Berry A Cloning, over-expression, purification, and characterisation ofN-acetylneuraminate synthase fromStreptococcus agalactiae Protein Expression and Purification 27 346-356, 2003
DOI:10.1016/S1046-5928(02)00633-2

Harding M, Hodgson R, Majid T, McDowall KJ, Nelson AS A stereodivergent, two-directional synthesis of stereoisomeric C-linked disaccharide mimetrics Organic&Biomolecular Chemistry 1 338-349, 2003
DOI:10.1039/b208781b

Nelson AS Benzothiopyranones, 2003

Nelson AS Asymmetric phase transfer catalysis, 2003

Nelson AS 3-Oxidopyrylium salts and their benzo-fused and thio-analogues, 2003

Harding M, Hodgson RD, Majid T, McDowall KJ, Nelson AS A stereodivergent, two-directional synthesis of steroismericC-linked disaccharide mimetics Organic Letters 1 338-349, 2002

Nelson AS, Harding M, Hodgson R Sequential kinetic resolution of C-2-symmetric compounds as a key step in two-directional synthesis: structural requirements for efficient resolution of difuryl diols Royal Society of Chemistry. Journal: Perkin Transactions 1 2403-2413, 2002

Hodgson R, Majid T, Nelson A Desymmetrisation of meso difuryl alcohols, diols and their derivatives: complementary directed and undirected asymmetric dihydroxylation reactions J CHEM SOC PERK T 1 1631-1643, 2002
DOI:10.1039/b204904j

Hodgson R, Majid T, Nelson A Desymmetrisation of meso difuryl alcohols, diols and their derivatives: complementary directed and undirected asymmetric dihydroxylation reactions J CHEM SOC PERK T 1 1631-1643, 2002
DOI:10.1039/b204904j

Nelson AS, Hodgson R, Majid T Towards complete stereochemical control: complementary methods for the synthesis of six diastereoisomeric monosaccharide mimetics Royal Society of Chemistry. Journal: Perkin Transactions 1 1444-1454, 2002

Nelson AS, Hodgson R, Mahid T Desymmetrisation of meso difuryl alcohols, diols and their derivatives: complementary directed and undirected asymmetric dihydroxylation reactions Royal Society of Chemistry. Journal: Perkin Transactions 1 1631-1634, 2002

Holland JM, Lewis M, Nelson A First Desymmetrization of a Centrosymmetric Molecule in Natural Product Synthesis: Preparation of a Key Fragment in the Synthesis of Hemibrevetoxin B This work was supported by the University of Leeds (through a Brotherton Scholarship to J.M.H.) and Pfizer. We are extremely grateful to Professor T. Nakata of the Institute of Physical and Chemical Research (RIKEN), Saitama, Japan, for providing us with the NMR spectra of the epoxide 2, the Royal Society for a grant, and AstraZeneca for strategic research funding. Angew Chem Int Ed Engl 40 4082-4084, 2001

Holland JM, Lewis M, Nelson AS First Desymmetrization of a Centrosymmetric Molecule in Natural Product Synthesis: Preparation of a Key Fragment in the Synthesis of Hemibrevetoxin B Angewandte Chemie: International Edition 40 4082-4084, 2001
DOI:10.1002/1521-3773(20011105)40:21<4082::AID-ANIE4082>3.0.CO;2-T

Hodgson R, Mahid T, Nelson AS Directed and undirected asymmetric dihydroxylation reactions: application in the synthesis of a C-linked analogue of allolactose Chemical Communications 2076-2077, 2001
DOI:10.1039/b107643d

Harding M, Nelson A A general, two-directional synthesis of C-(1 ->6)-linked disaccharide mimetics: synthesis from non-carbohydrate based starting materials CHEM COMMUN 695-696, 2001

Holland JM, Lewis M, Nelson A First desymmetrization of a centrosymmetric molecule in natural product synthesis: Preparation of a key fragment in the synthesis of hemibrevetoxin B ANGEW CHEM INT EDIT 40 4082-+, 2001

Nelson AS Looking in the mirror Chemistry Review 10 6-9, 2001

Nelson AS, Christlieb M, Aftab T, Carter C, Hart J Stereospecific conversion of (1R*, 3S*)- and (1R*, 3R*)-3-cyclohexyl-1-phenylpropane-1,3-diol into the corresponding 2,4-disubstituted oxetanes Royal Society of Chemistry. Journal: Perkin Transactions 1 5 711-722, 2000

Green S, Nelson A, Warriner S, Whittaker B Synthesis and investigation of the configurational stability of some dimethylammonium borate salts J CHEM SOC PERK T 1 4403-4408, 2000
DOI:10.1039/b005954o

Green S, Nelson A, Warriner S, Whittaker B Synthesis and investigation of the configurational stability of some dimethylammonium borate salts J CHEM SOC PERK T 1 4403-4408, 2000
DOI:10.1039/b005954o

Nelson AS, Warren S Control of remote stereochemistry using phosphine oxides: Formal synthesis of any stereoisomer diol (RR,RS, SR or SS) bearing 1,5-related stereogenic centres across anEdouble bond. Royal Society of Chemistry. Journal: Perkin Transactions 1 14 1983-1998, 1999

Nelson AS Asymmetric phase-transfer catalysis Angewandte Chemie: International Edition 38 1583-1585, 1999

Nelson AS, Aftab T, Carter C, Hart J A method for the stereospecific conversion of 1,3-diols into oxetanes Tetrahedron Letters 40 8679-8683, 1999

Nelson AS, Warren S Stereocontrol with phosphine oxides: synthesis of optically active cyclopropyl ketones. Royal Society of Chemistry. Journal: Perkin Transactions 1 23 3425-3433, 1999

Nelson AS, Warren S 1,3-Stereocontrol with phosphine oxides: Asymmetric synthesis of all four diastereoisomers of a gamma-benzyloxyl beta-hydroxy phosphine oxide. Royal Society of Chemistry. Journal: Perkin Transactions 1 1963-1982, 1999

Nelson AS, Mitchell HJ, Warren S Strategies for the stereoselective synthesis of molecules with remote stereogenic centres across a double bond of fixed configuration Royal Society of Chemistry. Journal: Perkin Transactions 1 1899-1914, 1999