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Frans Muller

Professor in Chemical Process Engineering
Member of the Process Research and Development group

Contact details

SPEME
Room: 2.35
Tel: +44 (0)113 3435637
Chemistry
Room: 4.10a
Tel: +44 (0)113 3432933
Email: F.L.Muller@leeds.ac.uk

Keywords

Flow reactions and continuous processing
Modular equipment design
Process design, development and scale up
Kinetic modelling
Risk assessment

Photograph of Frans Muller

Research interests

As a chemical engineer most aspects of manufacturing chemicals and products interest me. I am building a group working on chemical processing which initially will focus on the scale-up of continuous flow chemistry, mechanistic modelling and simulation, and the interaction between process and equipment. There are three key themes to my work:

  1. Phenomena
    Mixing, Multi Phase reactions, Unit Processes
    Nucleation, Solidification, Yields stress, Thixotropic fluids
    Flow Field Validation
  2. Modelling
    Mechanistic, Kinetics
    Thermodynamic
    CFD, LES for Flow, 3D Mechanistic
    Development and Scale up workflows and risk assessment
  3. Process Technology
    Flow Chemistry, Slow Flow Reactors
    Work up, Process driven scale-up, Plug and Produce

The work is supported by the Leeds transformation Fund

Useful links

Personal pages   
PhD Project: Experimental design for scalable continuous processes   
iPRD Centre for Doctoral Training Studentships   
Institute of Particle Science & Engineering

Publications

Hone CA, Holmes N, Akien GR, Bourne RA, Muller FL Rapid multistep kinetic model generation from transient flow data REACTION CHEMISTRY&ENGINEERING 2 103-108, 2017
DOI:10.1039/c6re00109b

Camacho DM, Roberts KJ, Muller F, Thomas D, More I, Lewtas K Morphology& growth of methyl stearate as a function of crystallization environment Crystal Growth and Design 17 563-575, 2017
DOI:10.1021/acs.cgd.6b01436
View abstract

Stamatiou IK, Muller FL Determination of mass transfer resistances of fast reactions in three-phase mechanically agitated slurry reactors AIChE Journal 63 273-282, 2017
DOI:10.1002/aic.15540
View abstract

Hone CA, Bourne RA, Muller FL Continuous-flow reactors for the rapid evolution and validation of kinetic motifs Chimica Oggi - Chemistry Today 33 14-20, 2015
View abstract

Singh R, Godfrey A, Gregertsen B, Muller F, Gernaey KV, Gani R, Woodley JM Systematic substrate adoption methodology (SAM) for future flexible, generic pharmaceutical production processes Computers and Chemical Engineering 58 344-368, 2013
DOI:10.1016/j.compchemeng.2013.07.010
View abstract

Muller FL How green is your engineering proposal? Life cycle impact assessment in High Value Chemical Manufacturing CHIMICA OGGI-CHEMISTRY TODAY 31 34-38, 2013

Singh R, Rozada-Sanchez R, Dean W, Perkins J, Muller F, Godfrey A, Gernaey KV, Gani R, Woodley JM A generic process template for continuous pharmaceutical production Computer Aided Chemical Engineering 31 715-719, 2012
DOI:10.1016/B978-0-444-59507-2.50135-9
View abstract

MacLeod CS, Muller FL On the fracture of pharmaceutical needle-shaped crystals during pressure filtration: Case studies and mechanistic understanding Organic Process Research and Development 16 425-434, 2012
DOI:10.1021/op200279m
View abstract

Muller FL, Abhishek MS, Choudhari S Observations of solid–liquid systems in anchor agitated vessels Chemical Engineering Research and Design 90 750-756, 2012
DOI:10.1016/j.cherd.2011.09.018

Barigou M, Muller FL Mixing of Pharmaceutical Solid-Liquid Suspensions In Pharmaceutical Blending and Mixing , 2012
DOI:10.1002/9781118682692.ch10
View abstract

Singh R, Rozada-Sanchez R, Wrate T, Muller F, Gernaey KV, Gani R, Woodley JM A retrofit strategy to achieve "Fast, Flexible, Future (F3)" pharmaceutical production processes Computer Aided Chemical Engineering 29 291-295, 2011
DOI:10.1016/B978-0-444-53711-9.50059-6
View abstract

Muller FL, Gray KA, Robinson GE Understanding Scale Up and Quality Risks on the interface between Primary and Secondary Development. In Pharmaceutical Process Scale-Up. , 2011

Muller FL, Whitlock B An Alternative Method to Isolate Pharmaceutical Intermediates ORGANIC PROCESS RESEARCH&DEVELOPMENT 15 84-90, 2011
DOI:10.1021/op100207e

Steele G, Morgan P, Huang Z, Griffiths L, Gracin S, Black S, Muller F, Macleod C, Lawton SJ, Kavanagh A Manufacturing drug substance to meet formulation needs AIChE Annual Meeting, Conference Proceedings -, 2010

Muller FL, Black SN On the Effect of Temperature on Aqueous Solubility of Organic Solids. Organic Process Research&Development 14 661-665, 2010

Iverlund N, Parsons A, Muller F Carbon cartridges and their use as a purification step in pharmaceutical API processes Chemical Engineering Research and Design 87 852-858, 2009
DOI:10.1016/j.cherd.2008.12.016
View abstract

Muller FL, Latimer JM Anticipation of scale up issues in pharmaceutical development COMPUTERS&CHEMICAL ENGINEERING 33 1051-1055, 2009
DOI:10.1016/j.compchemeng.2008.09.015

Muller FL On the rheological behaviour of batch crystallisations CHEMICAL ENGINEERING RESEARCH&DESIGN 87 , 2009
DOI:10.1016/j.cherd.2008.11.014

Muller FL, Fielding M, Black S A Practical Approach for Using Solubility to Design Cooling Crystallisations ORGANIC PROCESS RESEARCH&DEVELOPMENT 13 1315-1321, 2009
DOI:10.1021/op9001438

Muller FL, Iverlund N, Parsons A Application of Carbon treatment cartridges in pharmaceutical processes. Chemical Engineering Research and Design 87 852-858, 2009

Pfluger R, Dettwiler HR, Hall A, Muller F, Carpenter K, Stoessel F, Suter S B. Simulation tools and their application in chemical manufacturing II Chimia 57 49-52, 2003
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Muller FL, Davidson JF On the effects of surfactants on mass transfer to viscous liquids in bubble columns Chemical Engineering Research and Design 73 291-296, 1995
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Muller FL, Davidson JF Rheology of Shear Thinning Polymer Solutions Industrial and Engineering Chemistry Research 33 2364-2367, 1994
DOI:10.1021/ie00034a016
View abstract

Muller FL, Davidson JF On the contribution of small bubbles to mass transfer in bubble columns containing highly viscous liquids Chemical Engineering Science 47 3525-3532, 1992
DOI:10.1016/0009-2509(92)85066-K
View abstract