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Patrick McGowan

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Member of the Process Research and Development group

Contact details

Room: 1.27
Tel: +44 (0)113 3436404
Email: P.C.McGowan@leeds.ac.uk

Keywords

Anti-tumour drugs
Organometallic compounds
Transition metal chemistry
Medicinal chemistry
Catalysis
Coordination chemistry

Photograph of Patrick McGowan

Research interests

Anti-Cancer Drugs
We have been working in this area for five years (Industrially funded postdoctoral fellow and PhD student) synthesising a range of potential anti-tumour compounds. We have developed the use of water and air stable and soluble titanium compounds as anti-tumour reagents towards cis-platin (conventional anti-tumour drug) resistant cell lines. Much of the work developed in this area involves patent applications. After in vitro testing, some of the compounds have shown extremely promising activity against cis-platin resistant cell lines. In vivo tests are currently underway and there is enormous potential for the further development of transitional metal compounds in this area.

The target molecules are derived from air and water sensitive precursors. Thus, the student will get training in handling air and water sensitive materials with the goal of making air and water stable materials given the techniques, expertise and the evidence that we have accumulated within the group. They would also get training in the biological in vitro testing of at Enact Pharma PLC, Salisbury, U.K.

Catalysis and Dihydrogen complexes
Our research group has been involved in the preparation, characterisation and evaluation of early and late transition metal compounds as catalysts. One area of interest is the use of late transition metal compounds as catalysts for the hydrogenation of polybutadiene (EPSRC funded). Working in catalysis with the industrial sector involves collaboration with BP Amoco PLC in the production of vinyl acetate using transition metal catalysts. We have also been working in the area of developing early transition organometallic compounds as ethene and propene polymerisation catalysts, and in the synthesis of polybutadiene catalysts.

We are interested in the preparation, stabilisation and characterisation of early and late transition metal dihydrogen complexes. We have prepared a number of new functionalised cyclopentadienyl and tri-azacyclononane ligands in our laboratories. Using our functionalised cyclopentadienyl and tri-azacyclononane complexes (EPSRC funding) we have been preparing transition metal organometallic and coordination hydride compounds. A student involved with these projects will manipulate air and water sensitive materials and synthesise new compounds which will be characterised using our multinuclear nmr facilities as well as our in-house microanalytical, mass spectrometry and x-ray crystallography facilities.

Publications

Lord RM, Allison SJ, Rafferty K, Ghandhi L, Pask CM, McGowan PC Cytotoxic hydrogen bridged ruthenium quinaldamide complexes showing induced cancer cell death by apoptosis Dalton Transactions 45 13196-13203, 2016
DOI:10.1039/c6dt01464j
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Lucas SJ, Lord RM, Basri AM, Allison SJ, Phillips RM, Blacker AJ, McGowan PC Increasing anti-cancer activity with longer tether lengths of group 9 Cp∗ complexes Dalton Transactions 45 6812-6815, 2016
DOI:10.1039/c6dt00186f
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Sambiagio C, Munday RH, John Blacker A, Marsden SP, McGowan PC Green alternative solvents for the copper-catalysed arylation of phenols and amides RSC Advances 6 70025-70032, 2016
DOI:10.1039/c6ra02265k
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Santoro A, Lord RM, Loughrey JJ, McGowan PC, Halcrow MA, Henwood AF, Thomson C, Zysman-Colman E One-pot synthesis of highly emissive dipyridinium dihydrohelicenes Chemistry - A European Journal 21 7035-7038, 2015
DOI:10.1002/chem.201406255
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Lord RM, Hebden AJ, Pask CM, Henderson IR, Allison S, Shepherd SL, Phillips RM, McGowan PC Hypoxia-Sensitive Metalβ-Ketoiminate Complexes Showing Induced Single Strand DNA Breaks and Cancer Cell Death by Apoptosis. Journal of Medicinal Chemistry -, 2015
DOI:10.1021/acs.jmedchem.5b00455
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Sherborne GJ, Chapman MR, Blacker AJ, Bourne RA, Chamberlain TW, Crossley BD, Lucas SJ, Mcgowan PC, Newton MA, Screen TEO, Thompson P, Willans CE, Nguyen BN Activation and deactivation of a robust immobilized Cp*Ir-transfer hydrogenation catalyst: A multielement in situ X-ray absorption spectroscopy study Journal of the American Chemical Society 137 4151-4157, 2015
DOI:10.1021/ja512868a
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Rodríguez-Bárzano A, Lord RM, Basri AM, Phillips RM, Blacker AJ, McGowan PC Synthesis and anticancer activity evaluation ofη5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands Dalton Transactions 44 3265-3270, 2015
DOI:10.1039/c4dt02748e
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Sambiagio C, Munday RH, Marsden SP, Blacker AJ, McGowan PC Picolinamides as effective ligands for copper-catalysed aryl ether formation: Structure-activity relationships, substrate scope and mechanistic investigations Chemistry - A European Journal 20 17606-17615, 2014
DOI:10.1002/chem.201404275
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Sambiagio C, Munday RH, Marsden SP, Blacker AJ, McGowan PC Picolinamides as effective ligands for copper-catalysed aryl ether formation: structure-activity relationships, substrate scope and mechanistic investigations Chemistry (Weinheim an der Bergstrasse, Germany) 20 17606-17615, 2014
DOI:10.1002/chem.201404275
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Santoro A, Sambiagio C, McGowan PC, Halcrow MA Synthesis and coordination chemistry of 1,1,1-tris-(pyrid-2-yl)ethane Dalton Transactions 44 1060-1069, 2014
DOI:10.1039/c4dt02824d
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Lord RM, Mannion JJ, Hebden AJ, Nako AE, Crossley BD, McMullon MW, Janeway FD, Phillips RM, McGowan PC Mechanistic and cytotoxicity studies of group IVβ-diketonate complexes. ChemMedChem 9 1136-1139, 2014
DOI:10.1002/cmdc.201402019
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Sambiagio C, Marsden SP, Blacker AJ, McGowan PC Copper catalysed Ullmann type chemistry: from mechanistic aspects to modern development. Chem Soc Rev 43 3525-3550, 2014
DOI:10.1039/c3cs60289c
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Almodares Z, Lucas SJ, Crossley BD, Basri AM, Pask CM, Hebden AJ, Phillips RM, McGowan PC Rhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agents. Inorg Chem 53 727-736, 2014
DOI:10.1021/ic401529u
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Rodríguez-Bárzano A, Fonseca JDA, Blacker AJ, Mcgowan PC Ruthenium halide complexes as N-alkylation catalysts European Journal of Inorganic Chemistry -, 2014
DOI:10.1002/ejic.201400117
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Zhang W, Hong L, Mcgowan PC A giant capsule from the self-assembly of a penta-telechelic hybrid poly(acrylic acid) based on polyhedral oligomeric silsesquioxane Macromolecular Chemistry and Physics -, 2014
DOI:10.1002/macp.201400012
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Zhang W, Hong L, McGowan PC A giant capsule from the self-assembly of a penta-telechelic hybrid poly(acrylic acid) based on polyhedral oligomeric silsesquioxane Macromolecular Chemistry and Physics 215 900-905, 2014
DOI:10.1002/macp.201400012
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Rodríguez-Bárzano A, Blacker AJ, McGowan PC Synthesis and characterisation of tetramethylfulvene complexes of ruthenium. Dalton Trans 42 16669-16671, 2013
DOI:10.1039/c3dt52747f
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Lucas SJ, Crossley BD, Pettman AJ, Vassileiou AD, Screen TE, Blacker AJ, McGowan PC A robust method to heterogenise and recycle group 9 catalysts. Chem Commun (Camb) 49 5562-5564, 2013
DOI:10.1039/c3cc42550a
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Lucas SJ, Lord RM, Wilson RL, Phillips RM, Sridharan V, McGowan PC Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents. Dalton Trans 41 13800-13802, 2012
DOI:10.1039/c2dt32104a
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Lucas SJ, McGowan PC, Blacker AJ Tethered [p]Cp* based[p]group 9 complexes as transfer hydrogenation catalysts, 2012

Blackburn RS, McGowan PC, Pask CM, Rayner CM CATALYSED DYE SYSTEMS, 2011
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Macrae RO, Pask CM, Burdsall LK, Blackburn RS, Rayner CM, McGowan PC Backside Cover: The Combined Synthesis and Coloration of Poly(lactic acid) (Angew. Chem. Int. Ed. 1/2011)., 2011
DOI:10.1002/anie.201006804

MacRae RO, Pask CM, Burdsall LK, Blackburn RS, Rayner CM, McGowan PC The Combined Synthesis and Coloration of Poly(lactic acid) Angewandte Chemie International Edition 50 291-294, 2010
DOI:10.1002/anie.201004920
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Tang T, Metanawin T, Hebden A, McGowan P, Wang XS Studies in micelle-mediated Pd nucleation. Chem Commun (Camb) 46 6663-6665, 2010
DOI:10.1039/c0cc01235a
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van Rijt SH, Hebden AJ, Amaresekera T, Deeth RJ, Clarkson GJ, Parsons S, McGowan PC, Sadler PJ Amide Linkage Isomerism As an Activity Switch for Organometallic Osmium and Ruthenium Anticancer Complexes J MED CHEM 52 7753-7764, 2009
DOI:10.1021/jm900731j

Blackburn RS, McGowan PC, Pask CM, Rayner CM Combined Synthesis and Coloration of Poly(lactic acid) - The DyeCat Process, 2009

McGowan PC, Temple CN New N-monofunctionalised 1,4,7-triazacyclononane complexes of iron INORG CHIM ACTA 362 3165-3171, 2009
DOI:10.1016/j.ica.2009.02.015

Camm KD, El-Sokkary A, Gott AL, Stockley PG, Belyaeva T, McGowan PC Synthesis, molecular structure and evaluation of new organometallic ruthenium anticancer agents DALTON T 10914-10925, 2009
DOI:10.1039/b918902e

Shi Q, Thatcher RJ, Slattery J, Sauari PS, Whitwood AC, McGowan PC, Douthwaite RE Synthesis, Coordination Chemistry and Bonding of Strong N-Donor Ligands Incorporating the 1H-Pyridin-(2E)-Ylidene (PYE) Motif CHEM-EUR J 15 11346-11360, 2009
DOI:10.1002/chem.200901382

Allen OR, Knox RJ, McGowan PC Functionalised cyclopentadienyl zirconium compounds as potential anticancer drugs. Dalton transactions (Cambridge, England : 2003) 5293-5295, 2008
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Gott AL, McGowan PC, Podesta TJ Controlling the binding of dihydrogen using ruthenium complexes containing N-mono-functionalised 1,4,7-triazacyclononane ligand systems. Dalton Trans 3729-3738, 2008
DOI:10.1039/b804572k
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Gott AL, McGowan PC, Temple CN Controlling the coordination mode of 1,4,7-triazacyclononane complexes of rhodium and iridium and evaluating their behavior as phenylacetylene polymerization catalysts ORGANOMETALLICS 27 2852-2860, 2008
DOI:10.1021/om800180a

Allen OR, Knox RJ, McGowan PC Functionalised cyclopentadienyl zirconium compounds as potential anticancer drugs DALTON T 1293-1295, 2008
DOI:10.1039/b812244j

Mokuolu QF, Kilner CA, McGowan PC, Halcrow MA Mononuclear and unsymmetric dinuclear complexes of the tripodal ligand 2-hydroxyethyl-bis(2-{pyrid-2-yl}ethyl)amine INORG CHIM ACTA 360 4025-4030, 2007
DOI:10.1016/j.ica.2007.04.046

Blackburn RS, Rayner CM, Pask CM, McGowan PC Novel catalytic materials and their use in the preparation of colored polymeric materials, 2007
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Mokuolu QF, Foguet-Albiol D, Jones LF, Wolowska J, Kowalczyk RM, Kilner CA, Christou G, McGowan PC, Halcrow MA Four copper(ii) pyrazolido complexes derived from reactions of 3{5th CuF2or Cu(OH)2 Dalton Transactions 1392-1399, 2007
DOI:10.1039/b618780c
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McGowan PC, Halcrow MA, Kilner CA, Mokuolu QF, Foguet-Albiol D, Jones LF, Wolowska J, Kowalczyk RM, Christou G Four copper(II)pyrazolido complexes derived from reactions of 3(5)-substituted pyrazoles with CuF2 or Cu(OH)(2) Dalton Transactions 1392-1399, 2007

Allen OR, Gott AL, Hartley JA, Hartley JM, Knox RJ, McGowan PC functionalised cyclopentadienyl titanium compounds as potential anticancer drugs Dalton Transactions 43 5082-5090, 2007

Mokuolu QF, Kilner CA, Barrett SA, McGowan PC, Halcrow MA An unusual zinc-promoted decomposition of a bis(2-{pyrid-2-yl}ethyl)amine derivative. Inorg Chem 44 4136-4138, 2005
DOI:10.1021/ic050270o
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McGowan PC, Rayner CM, Blackburn RJ Novel catalytic materials and their use in the preparation of polymeric materials, 2005

McGowan PC Metal complexes as pharmaceuticals. In Rep. Prog. Chemistry , 2005

Camm KD, Furtado SJ, Gott AL, McGowan PC Synthesis and structural studies of bis-amino-functionalised ferrocene salts and ferrocenium salts POLYHEDRON 23 2929-2936, 2004
DOI:10.1016/j.poly.2004.07.020

Furtado SJ, Gott AL, McGowan PC Synthesis of mono-amino-functionalised ferrocene, ferrocene salts and ferrocenium salts. Dalton Trans 436-441, 2004
DOI:10.1039/b315359m
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Gott AL, McGowan PC, Podesta TJ, Tate CW Formation and structural studies of iron(III) and ruthenium(II) complexes of 1,4,7-triazacyclononane and N-monofunctionalised 1,4,7-triazacyclononane Inorganica Chimica Acta 357 689-698, 2004
DOI:10.1016/j.ica.2003.07.002

Gott AL, McGowan PC, Temple CN The formation, reactivity and interconversion of novel eta(1)- and eta(3)-triazacyclononane complexes of rhodium(I) and rhodium(III) DALTON T 1841-1845, 2004
DOI:10.1039/b401877j

Knox RJ, McGowan PC Metallocenes as Anti-Tumour Reagents 005305, 2004

Allen OR, Croll L, Gott AL, Knox RJ, McGowan PC Functionalized cyclopenadienyl titanium organometalic compounds as new antitumor drugs Organometallics 23 288-292, 2004
DOI:10.1021/om030403i

Allen OR, Croll L, Gott AL, Knox RJ, McGowan PC Functionalized Cyclopentadienyl Titanium Organometallic Compounds as New Antitumor Drugs Organometallics 23 288-292, 2003
DOI:10.1021/om030403i

Gott AL, McGowan PC, Thornton-Pett MA Carbonyl 1-(2-pyridylmethyl)-1,4,7-trizacyclononane-kappa N-4 (triphenyl-phosphine)ruthenium(II) dichloride dichloromethane sesquisolvate Acta Crystallographica. Section C: Crystal Structure Communications 59 M1015-M1017, 2003

Gott AL, McGowan PC 1,4,7-Tris(p-toluenesulfonyl)-1,4,7-triaza cyclononane ACTA CRYSTALLOGR E 59 O1702-O1703, 2003
DOI:10.1107/S1600536803022384

Gott AL, McGowan PC 1,4,7-Tris(p-toluenesulfonyl)-1,4,7-triaza cyclononane Acta Crystallographica. Section B: Structural Science 59 1702-1703, 2003

Corradi M, McGowan MAD, McGowan PC, Thornton-Pett MA The synthesis and strucutre of bis-and tris(amino)- functionalised cyclopentadienylyttrium derivatives European Journal of Solid State and Inorganic Chemistry 2362-2366, 2002
DOI:10.1002/1099-0682(200209)2002:9<2362::AID-EJIC2362>3.0.CO;2-V

Bradley S, Corradi MM, Camm KD, Furtado SJ, McGowan PC, Mumtaz R, Thornton-Pett M Synthesis and reactivity of Group 14 substituted amino-functionalised cyclopentadienyl compounds J ORGANOMET CHEM 656 49-56, 2002

Bradley S, Camm KD, Furtado SJ, Gott AL, McGowan PC, Podesta TJ, Thornton-Pett M Synthesis and structure of amino-functionalized cyclopentadienyl vanadium complexes and evaluation of their butadiene polymerization behavior ORGANOMETALLICS 21 3443-3453, 2002
DOI:10.1021/om020170f

McGowan PC Chemotherapy in transition - Could a new class of Ru-containing compounds offer another potential cancer therapy? Chemistry in Britain 38 pp.21-, 2002

Bradley S, Camm KD, Liu XM, McGowan PC, Mumtaz R, Oughton KA, Podesta TJ, Thornton-Pett M Synthesis and structural studies of 1,1 '-bis-amino-functionalized ferrocenes, ferrocene salts, and ferrocenium salts INORG CHEM 41 715-726, 2002
DOI:10.1021/ic010821k

McGowan PC, Thornton-Pett MA, Bradley S, Camm K, Furtado SJ, Gott AL, Podesta T The synthesis and structure of amino-functionalised cyclopentadienul vanadium complexes and evaluation of their butadiene polymerisation behaviour Organometallics 21 3443-3453, 2002
DOI:10.1021/om020170f

Gott AL, McGowan PC, Podesta TJ, Thornton-Pett M Pendant arm N-monofunctionalised 1,4,7-triazacyclononane complexes of Fe(II) and Ru(II) J CHEM SOC DALTON 3619-3623, 2002
DOI:10.1039/b205344f

Knox RJ, McGowan PC Ionic Metallocenes as a New Form of Anti-Tumour Agents (0215593.5), 2002

McGowan PC, Page EM, Whittlesey MK, Lynam JM Complexes containing metal-carbonσ-bonds of the groups titanium to manganese, including carbenes and carbynes Organometallic Chemistry 29 227-288, 2001

McGowan PC, Thornton-Pett MA, Podesta T Toward the development of amino: Functionalised cyclo pentadienyl vanadium complexes, 2001

McGowan PC, Gott AL, Podesta TJ, Thornton-Pett M Molecular hydrogen complexes containing monofunctionalized 1,4,7-triazacyclononane ligand systems. ABSTR PAP AM CHEM S 222 U607-U607, 2001

McGowan PC, Gott AL, Podesta T, Thornton-Pett MA Molecular hydrogen complexes containing monofunctionalized 1,4,7-triazacyclonane ligand systems, 2001

McGowan PC, Furtado SJ, Thornton-Pett MA, Podesta TJ Toward the development of amino: Functionalized cyclo pentadienyl vanadium complexes. ABSTR PAP AM CHEM S 222 U609-U609, 2001

McGowan PC, Podesta T, Thornton-Pett MA N-monofunctionalized 1,4,7-Triazacyclonane macrocycles as building blocks in inorganic crystal engineering Inorganic Chemistry 40 1445-1453, 2001
DOI:10.1021/ic0006854

McGowan PC Return to zero. Separating titanium and lanthanides from their ores is being made easier with new technology Chemistry in Britain 37 pp.21-, 2001

Kee TP, McGowan PC Sticks and stones may break my bones Education in Chemistry 38 72-74, 2001

McGowan PC Cancer Therapy Gets Heavy Education in Chemistry 38 134-136, 2001

McGowan PC Group 4 Titanium-Carbon o-Bond Complexes Royal Society of Chemistry. Annual Reports on the 29 227-256, 2001

McGowan PC, McGowan MAD Titanocene Synthesis, 2001

McGowan PC, McGowan MAD British Patent 9929353.2: Metallocene synthesis, 1999

Bradley S, McGowan PC, Thornton-Pett MA, Oughton KA, Walsh ME Facile synthesis of amino-functionalised ferrocenes and vanadocenes Chemical Communications 77-78, 1999

Abboud KA, He Y, McElwee-White L, McGowan PC Oxidation of the zwitterionic tungsten amide (OC)5WNPhNPhC(OMe)Ph with Br2and PCl5. Formation of [(PhN)W(CO)2X2]2and [(PhN)W(CO)2X2L (X=Br or Cl; .... Dalton Transactions 20 3373-3378, 1998

McGowan PC, Donnadieu B, Hart CE, Poilblanc R Facile synthesis of amino-functionalised cyclopentadienyl sodium compounds and subsequent formation of rhodium complexes: proton-deuterium exchange for the soldium salts Journal of Organometallic Chemistry 528 191-194, 1997

McGowan PC, Brabec V, Howsen SE, Kaner RA, Lord RM, Malina J, Phillips RM, Abdallah QMA, Rodger A, Scott P Metallohelices with Activity Against Cisplatin-Resistant Cancer Cells; does the mechanism involve DNA binding? Chemical Science -,
DOI:10.1039/C3SC51731D

Lord RM, Lord SM, Pask CM, McGowan PC Structural studies of titanium(IV) picolinamide alkoxide and oxide derivatives Polyhedron -,
DOI:10.1016/j.poly.2016.04.017
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