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Ron Grigg FRS

Emeritus Professor
Member of the Chemical Biology and Medicinal Chemistry group

Contact details

Room: 1.10a
Tel: +44 (0)113 3436501
Email: R.Grigg@leeds.ac.uk

Keywords

Cascade amd Supercascade Reactions
Heterocyclic Chemistry
Palladium,Rhodium,Ruthenium,Iridium Catalysed Reactions
1, 3-Dipolar Cycloaddition Reactions
Asymmetric Synthesis
Medicinal Chemistry
Combinatorial Chemistry

Photograph of Ron Grigg FRS

Research interests

Our research is focussed on developing new multicomponent cascade and supercascade reactions that involve both cycloaddition and transition metal catalysed processes. These provide well defined access to regions of biochemical space. The cycloaddition processes involve simple starting materials (imines, oximes, hydrazones etc) and allow the rapid assembly of complex heterocycles in regio-, stereo- and chemo-selective thermal or metal catalysed processes. The multicomponent cascades involve the combination of 3/5/7/9 etc chemical building blocks in a single step via designed well ordered molecular queuing. Asymmetric versions of these cascades, employing chiral catalysts, are under development. Bimetallic cascade catalysis involving Pd/Ag, Pd/In, Pd/Rh, Pd/Ir and Pd/Ru in which the substrates are passed from one metal to the other are being studied and new synthetic strategies are being developed based on these combinations. The new chemistry is being applied to biochemical, medicinal and agrochemical problems. The biology of promising products is being studied in Leeds, Sheffield, Edinburgh, Leicester, Cancer Research UK and in overseas labs in Australia, USA and Europe. There are also strong collaborations with Turkey, Egypt and Thailand (patent filed on an antimalarial).

Publications

Elboray EE; Gao C; Grigg R Skeletal diversity via Pd(0) catalysed three-component cascades of allene and halides or triflates with protected hydroxylamines and formamide Tetrahedron 68 3103-3111, 2012
DOI:10.1016/j.tet.2012.01.099
View abstract

Gillespie J; Savic S; Wong C; Hempshall A; Inman M; Emery P; Grigg R; McDermott MF Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Rheum 64 418-422, 2012
DOI:10.1002/art.33382
View abstract

Elboray EE; Gao C; Grigg R Skeletal diversity via Pd(0) catalysed three-component cascades of allene and halides or triflates with protected hydroxylamines and formamide Tetrahedron -, 2012

Lewis-Wambi JS; Kim H; Curpan R; Grigg R; Sarker MA; Jordan VC The Selective Estrogen Receptor Modulator Bazedoxifene Inhibits Hormone-Independent Breast Cancer Cell Growth and Down-Regulates Estrogen Receptor alpha and Cyclin D1 MOL PHARMACOL 80 610-620, 2011
DOI:10.1124/mol.111.072249

Nural Y; Dondas HA; Grigg R; Sahin E POLYSUBSTITUTED FUSED RING BICYCLIC THIOHYDANTOINS FROM AMINOCARBO-N-THIOYLPYRROLIDINES DERIVED FROM AZOMETHINE YLIDE 1,3-DIPOLAR CYCLOADDITIONS HETEROCYCLES 83 2091-2114, 2011
DOI:10.3987/COM-11-12276

Elboray EE; Grigg R; Fishwick CWG; Kilner C; Sarker MAB; Aly MF; Abbas-Temirek HH X=Y-ZH compounds as potential 1,3-dipoles. Part 65: atom economic cascade synthesis of highly functionalized pyrimidinylpyrrolidines TETRAHEDRON 67 5700-5710, 2011
DOI:10.1016/j.tet.2011.05.074

Grigg R; Mutton SP Pd-catalysed carbonylations: versatile technology for discovery and process chemists TETRAHEDRON 66 5515-5548, 2010
DOI:10.1016/j.tet.2010.03.090

Gillespie J; Savic S; Wong C; Emery P; Grigg R; McDermott MF HDAC ACTIVITY: A THERAPEUTIC TARGET IN RHEUMATOID ARTHRITIS?, 2010

Kongkathip N; Pradidphol N; Hasitapan K; Grigg R; Kao WC; Hunte C; Fisher N; Warman AJ; Biagini GA; Kongsaeree P; Chuawong P; Kongkathip B Transforming Rhinacanthin Analogues from Potent Anticancer Agents into Potent Antimalarial Agents J MED CHEM 53 1211-1221, 2010
DOI:10.1021/jm901545z

Grigg R; Husinec S; Savic V Stereoselective cyclo-addition reactions of azomethine ylides catalysed by in situ generated Ag(I)/bisphosphine complexes J SERB CHEM SOC 75 1-9, 2010
DOI:10.2298/JSC1001001G

Sakee U; Nasuk C; Grigg R Synthesis of 1-C-(tetra-O-acetyl-beta-D-galactopyranosyl)-2,3-diiodo-1-propene and its reaction with primary amines CARBOHYD RES 344 2096-2099, 2009
DOI:10.1016/j.carres.2009.06.021

Nural Y; Kilincarslan R; Dondas HA; Cetinkaya B; Serin MS; Grigg R; Ince T; Kilner C Synthesis of Ni(II), Pd(II) and Cu(II) metal complexes of novel highly functionalized aroylaminocarbo-N-thioyl pyrrolidines and their activity against fungi and yeast POLYHEDRON 28 2847-2854, 2009
DOI:10.1016/j.poly.2009.06.028

Grigg R; Whitney S; Sridharan V; Keep A; Derrick A Iridium catalysed alkylation of 4-hydroxy coumarin, 4-hydroxy-2-quinolones and quinolin-4(1H)-one with alcohols under solvent free thermal conditions TETRAHEDRON 65 7468-7473, 2009
DOI:10.1016/j.tet.2009.07.027

Grigg R; Whitney S; Sridharan V; Keep A; Derrick A Iridium catalysed C-3 alkylation of oxindole with alcohols under solvent free thermal or microwave conditions TETRAHEDRON 65 4375-4383, 2009
DOI:10.1016/j.tet.2009.03.065

Grigg R; Lofberg C; Whitney S; Sridharan V; Keep A; Derrick A Iridium catalysed alkylation of tert-butyl cyanoacetate with alcohols under solvent free conditions TETRAHEDRON 65 849-854, 2009
DOI:10.1016/j.tet.2008.11.040

Grigg R; Somasunderam A; Sridharan V; Keep A Palladium-Catalysed Cascades Triggered by Dehydrogenation of Secondary or Tertiary Amines: Access to Bridged- and Fused-Ring Heterocycles SYNLETT 97-99, 2009
DOI:10.1055/s-0028-1087480

Sakee U; Grigg R First Synthesis of 5-Chloro-7-[1,3]oxazolo[4,5-b]pyridin-2-ylquinolin-8-ol by Pd-Catalyzed Arylation SYNTHETIC COMMUN 39 3031-3037, 2009
DOI:10.1080/00397910902730861

Brimble M; St Clair Black D; Ciufolini MA; Fukuyama T; Fürstner A; Grigg R; Hiemstra H; MacMillan DWC; Shibasaki M; Tietze L; Wipf P Editorial Advisory Board Members Progress in Heterocyclic Chemistry 2008-2009 Progress in Heterocyclic Chemistry 21 -, 2009
DOI:10.1016/S0959-6380(09)70027-3

Grigg R; Sridharan V; Shah M; Mutton S; Kilner C; MacPherson D; Milner P Regioselective synthesis of N-aminoisoindolones and mono-N- and di-N,N'-substituted phthalazones utilizing hydrazine nucleophiles in a palladium-catalyzed three-component cascade process. J Org Chem 73 8352-8356, 2008
DOI:10.1021/jo800822p
View abstract

Grigg R; Sridharan V; Sykes DA Sonogashira/N-acyliminium ion aromatic pi-cyclisation processes: access to tetra- and pentacyclic lactams TETRAHEDRON 64 8952-8962, 2008
DOI:10.1016/j.tet.2008.06.044

Cleghorn LAT; Grigg R; Savic V; Simic M Reactive organoallyl species generated from aryl halides and allene: allylation of alpha,beta-unsaturated aldehydes and cyclic ketones employing Pd/In transmetallation processes TETRAHEDRON 64 8731-8737, 2008
DOI:10.1016/j.tet.2008.06.100

Grigg R; Kilner C; Sarker MAB; de la Cierva CO; Dondas HA X=Y-ZH compounds as potential 1,3-dipoles. Part 64: Synthesis of highly substituted conformationally restricted and spiro nitropyrrolidines via Ag(I) catalysed azomethine ylide cycloadditions TETRAHEDRON 64 8974-8991, 2008
DOI:10.1016/j.tet.2008.05.132

Grigg R; Blacker J; Kilner C; McCaffrey S; Savic V; Sridharan V Stereoselective synthesis of chiral beta(2,3)-disubstituted-beta-amino acid derivatives using Pd/In transmetallation cascade processes TETRAHEDRON 64 8177-8181, 2008
DOI:10.1016/j.tet.2008.06.037

Grigg RE; Inman MW; Kilner CA; Koppen I; Marchbank J; Selby PJ; Sridharan V Synthesis of Carbo- and Heterocycles via Palladium Catalysed cascade Allene Insertion-Nucleophile Incorporation- Michael Addition Processes Tetrahedron 63 6152-6169, 2007
DOI:10.1016/j.tet.2007.03.044

Grigg RE; Kilner CA; Senthilnanthanan M; Seabourne CR; Sridharan V; Murrer BA Cyclometallated Ir(III), Rh(III) and Ru(II) Complexes as Catalysts for the Cyclotrimerisation of 1,6-Diynes with Monoynes. Arkivoc (Archive for Organic Chemistry) 145-160, 2007

Grigg RE; Whitney SJ; Derrick A; Keep A [Cp*IrCl2]2 Catalysed Indirect Functionalisation of Alcohols : Novel Strategies for the Synthesis of Indoles. Organic Letters 3299-3302, 2007

Grigg RE; Sarker M; Thayaparan A; Sridharan V; Fishwick CWG . Pd(0) Catalysed Three-Five Component C-2-Arylallyation of Active Methylene Heterocycles: Pyrazolones, Oxazoles, Isoxazolones and N,N’-Dimethylbarbituric Acid. Tetrahedron 7213-7228, 2007

Grigg RE; Sridharan V Isoindolones and Related N-Heterocycles via Palladium Nanoparticle - Catalysed 3-Component Cascade Reactions In New Avenues to Efficient Chemical Synthesis. Emerging Technologies , 2007

Lofberg C; Grigg RE; Keep A; Derrick A; Sridharan V; Kilner CA Sequential One-Pot Bimetallic Ir(III)/Pd(0) Catalysed Mono-/bis Alkylation and Spirocyclisation Processes of 1,3 - Dimethylbarbituric Acid and Allenes Chemical Communications 2006 5000-5002, 2006
DOI:10.1039/b614098j

Grigg RE; Sridharan V; Anwar U; Fielding M; Urch CJ Palladium Catalysed Tandem Cyclisation-Anion Capture Processes. Part 8 : In situ and Preformed Organostannanes. Carbonyl Chlorides and other Starter Species Journal of Organometallic Chemistry 691 1476-1487, 2006
DOI:10.1016/j.jorganchem.2005.11.045

Grigg RE; Kilner CA; Mariani E; Sridharan V Palladium Catalysed Cyclisation-Anion Capture Processes: In Situ Zipper Generation via Intramolecular Nucleophilic Capture ofπ Allylpalladium Species. Synlett -, 2006

Grigg RE; Kilner CA; Lofberg C; Keep A; Derrick A; Sridharan V Microwave Accelerated Redox Neutral Processes: Sequential One-Pot Ir(III)/Pd(0) Catalysed Monoalkylation/Spirocyclisation of Dimethyl Barbituric Acid Employing Alcohols and Allenes. Chemical Communications 5000-5002, 2006

Grigg RE; Sakee U; Sridharan V; Sukirthalingam S; Thangavalanthum R Palladium Catalysed Bis- and Tris-Cyclisations Furnishing Fused Cyclopropyl Carbo/Heterocycles. Tetrahedron 62 9523-9532, 2006

Grigg RE; Kilner CA; Mariani E; Sridharan V Palladium Catalysed Cyclisation-Anion Capture Processes: In situ Zipper Generation via Intramolecular Nucleophilic Capture ofπ-Allylpalladium Species Synlett 3021-3024, 2006

Grigg RE; Lofberg C; Whittaker MA; Keep A; Derrick A An Efficient Solvent-free Selective Monoalkylation of Arylacetonitriles with Mono-, Bis- and Tris-Primary Alcohols Catalysed by a Cp* Ir Complex The Journal of Organic Chemistry (Washington) 8023-8027, 2006

Grigg RE; Sarker MAB X=Y-ZH Systems as Potential 1,3-Dipoles. Part 63. Silver Catalysed Azomethine Ylide Cycloaddition; the Synthesis of Spirohomoserine Lactone Analogues. Tetrahedron 62 10332-10343, 2006

Grigg RE; Cook AJ “Catch and Release” Cascades: a Resin-Mediated Three- Component Cascade Approach to Small Molecules Tetrahedron 62 12172-12181, 2006

Grigg RE; McCaffrey S; Sridharan V; Fishwick CWG; Kilner CA; Korn S; Bailey K; Blacker J Enantioselective Synthesis of Non-Proteinogenic 2-Arylallylα-Amino Acids via Pd/In Catalytic Cascades. Tetrahedron 62 12159-12171, 2006

Grigg RE; Sarker MAB; O'Regan RM; Osipo C; Lee ES; Meeke K; Morris C; Bertucci A; Jordan VC Development and Therapeutic Options for the Treatment of Raloxifene-stimulated Breast Cancer in Athymic Mice. Clinical Cancer Research 12 2255-2263, 2006

Dondas HA; Fishwick CWG; Gai X; Grigg RE; Kilner CA; Dumrongchai N; Kongathip B; Kongathip N; Polysuk C; Sridharan V Stereoselective Palladium-Catalyzed Four-Component Cascade Synthesis of Pyrrolidinyl-, Pyrazolidinyl-, and Isoxazolidinyl Isoquinolines Angewandte Chemie - International Edition 44 7570-7574, 2005
DOI:10.1002/anie.200502066

Grigg RE; Martin W; Morris JT; Sridharan V Four-component Pd-catalysed cascade/ring closing metathesis. Synthesis of heterocyclic enones Tetrahedron 61 11380-11392, 2005
DOI:10.1016/j.tet.2005.09.015

Grigg RE; Holloway S; McDonald S; Millington EL; Sarker M X=Y-ZH Systems as Potential 1,3-Dipoles. Part 61. Metal Exchanged Zeolites, Silver Oxide, Ni(II) and Cuprous Iodide as Catalysts for 1,3-Dipolar Cycloaddition Reactions of Imines Tetrahedron 61 8677-8685, 2005
DOI:10.1016/j.tet.2005.06.110

Grigg RE; Sridharan V; Cleghorn L; MacLachlan WS; Kilner CA Bimetallic catalytic synthesis of annelated benzazepines Chemical Communications 24 3071-3073, 2005

Grigg RE; Sridharan V; Gai X; Rajviroongit S; Songarsa S Synthesis of triazolo- and tetrazolo-tetrahydroisoquinolines and isoquinolines via temperature controlled palladium catalysed allene/azide incorporation/intramolecular 1,3-dipolar cycloaddition cascades Tetrahedron Letters 46 5899-5902, 2005
DOI:10.1016/j.tetlet.2005.06.120

Grigg RE; Sridharan V; Hasakunpaisarn A; Kilner CA; Kongathip B; Kongathip N; Pettman A Catalytic processes for the functionalisation and desymmetrisation of malononitrile derivatives Tetrahedron 61 9356-9367, 2005
DOI:10.1016/j.tet.2005.07.048

Grigg RE; Sridharan V; Dondas HA; Clique B; Morris JA; Kilner CA; Cetinkaya B Δ 3-Aryl/heteroaryl substituted heterocycles via sequential Pd-catalysed termolecular cascade/ring closing metathesis (RCM) Tetrahedron 61 10652-10666, 2005
DOI:10.1016/j.tet.2005.08.078

Grigg RE; Sridharan V; Collard S; Gai X; Keep A; Khamnaen T; Rajviroongit S; Zhang L Synthesis ofN-substituted isoindolinones via a palladium catalysed three-component carbonylation-amination-Michael addition cascade Canadian Journal of Chemistry 83 990-1005, 2005
DOI:10.1139/v05-111

Grigg RE; Sridharan V; Collard S; Evans P; Hinsley J; Korn S; Muir J; Nurnabi M; Suganthan S; Wolstenholme-Hogg PC 8-Methylquinoline palladacycles: stable and efficient catalysts for carbon-carbon bond formation Tetrahedron 61 9696-9704, 2005
DOI:10.1016/j.tet.2005.06.118

Grigg RE; Sarker MAB; Martin W X=Y-ZH Systems as Potential 1,3-Dipoles. Part 62. Cycloaddition of Metallo-azomethine Ylides Derived from Imino Phosphonates. Tetrahedron 61 10677-10682, 2005

Kongathip N; Luangkamin S; Kongathip B; Sangma C; Grigg RE; Kongsaeree P; Prabpai S; Pradidphol N; Pitaviriyagul S; Siripong P Synthesis of novel rhinacanthins and related anticancer naphthoquinone esters Journal of Medicinal Chemistry 47 4427-4438, 2004
DOI:10.1021/jm030323g

Dondas HA; Fishwick CWG; Grigg RE; Kilner CA 1, 3-Dipolar cycloaddition of stabilised and non-stabilised azomethine ylides derived from uracil polyoxin C (UPoC): access to nikkomycin anologues Tetrahedron 60 3473-3485, 2004
DOI:10.1016/j.tet.2004.02.028

Grigg RE; Nurnabi M; Sarkar M Dihydroforocoumarin and dihydrofurodihydropyrid-2-one derivatives via palladium catalysed cascades involving aryl/heteroaryl/vinyl iodides and allene followed by acid catalysed cyclisation Tetrahedron 60 3359-3373, 2004
DOI:10.1016/j.tet.2004.02.049

Grigg RE; Cook AJ HDAC Inhibitors, 2004

Grigg RE; McCaffrey S Novel chiral non-proteinogenic amino acids, 2004

Grigg RE; Cook AJ HDAC Inhibitors, 2004

Grigg RE; Zhang L; Collard S; Ellis P; Keep A Facile Generation and Morphology of Pd Nanoparticles from Palladacycles (PdCys) and Carbon Monoxide Journal of Organometallic Chemistry 689 170-173, 2004
DOI:10.1016/j.jorganchem.2003.09.049

Cleghorn L; Cooper IR; Grigg RE; MacLachlan WS; Sridharan V Additive effects in palladium-indium mediated Barbier type allylations Tetrahedron Letters 44 7969-7973, 2003
DOI:10.1016/j.tetlet.2003.08.103

Dondas HA; Grigg RE; Kilner CA X=Y=ZH Systems as potential 1,3-dipoles. Part 58: Cycloaddition route to chiral conformationally constrained (R)-pro-(S)-pro peptidomimetics Tetrahedron 59 8481-8487, 2003
DOI:10.1016/j.tet.2003.09.032

Cleghorn L; Cooper IR; Fishwick CWG; Grigg RE; MacLachlan WS; Rasparini M; Sridharan V Three-component bimetallic (Pd/In) mediated cascade allylation of C=X functionality - Part 1. Scope and Class 1 examples with aldehydes and ketones Journal of Organometallic Chemistry 687 483-493, 2003
DOI:10.1016/j.jorganchem.2003.09.047

Grigg RE; Zhang L; Collard S; Keep A Isoindolinones via a room temperature palladium nanoparticle- catalysed 3-component cyclative carbonylation-amination cascade Tetrahedron Letters 44 6979-6982, 2003
DOI:10.1016/S0040-4039(03)01805-7

Gai X; Grigg RE; Khamnaen T; Rajviroongit S; Sridharan V; Zhang L; Collard S; Keep A Synthesis of 3-substituted isoindolin-1-ones via a palladium-catalysed 3-component carbonylation/amination/Michael addition process Tetrahedron Letters 44 7441-7443, 2003
DOI:10.1016/j.tetlet.2003.08.036

Gai X; Grigg RE; Koppen I; Sridharan V; Marchbank JD Synthesis of carbo- and heterocycles via a palladium-catalysed allene insertion-nucleophile incorporation-Michael addition cascade Tetrahedron Letters 44 7445-7448, 2003
DOI:10.1016/j.tetlet.2003.08.034

Grigg RE; Martin W; Morris JA; Sridharan V Synthesis of Delta(3)-pyrrolines and Delta(3)- tetrahydropyridines via microwave-accelerated ring-closing metathesis Tetrahedron Letters 44 4899-4901, 2003
DOI:10.1016/S0040-4039(03)01080-3

Fishwick CWG; Grigg RE; Sridharan V; Virica J Sequential azomethine imine cycloaddition-palladium catalysed cyclisation processes Tetrahedron 59 4451-4468, 2003
DOI:10.1016/S0040-4020(03)00517-9

Cooper I; Grigg RE; Hardie MJ; MacLachlan WS; Sridharan V; Thomas WA Diastereoselective Pd/In bimetallic inter-intramolecular (class 2) cascade reactions of allenyl-imines and aryl iodides Tetrahedron Letters 44 2283-2285, 2003
DOI:10.1016/S0040-4039(03)00277-6

Grigg RE; Hodgson A; Morris JA; Sridharan V Sequential Pd/Ru-catalysed allenylation/olefin metathesis/1,3- dipolar cycloaddition route to novel heterocycles Tetrahedron Letters 44 1023-1026, 2003
DOI:10.1016/S0040-4039(02)02736-3

Grigg RE; Zhang L; Collard S; Keep A Palladium catalysed 2+2+1 intramolecular cycloaddition for the preparation of bicyclo 3.3.0 octa-1.5-dien-3-ones from 1,6- diynes Chemical Communications 1902-1903, 2003
DOI:10.1039/b302841k

Fishwick CWG; Grigg RE; Dondas HA; Kilner CA X=Y-ZH system as potential 1,3-dipoles. Part 59: Cascade 1,3-azaprotio cyclotransfer-1,3-dipolar cycloaddition (1,3-APT-1,3-DC) reactions of benzobicyclo[3.3.1]non-5-en-9-one Tetrahedron 59 9997-10007, 2003
DOI:10.1016/j.tet.2003.10.027

Grigg RE; Sridharan V; Abirami T Synthesis of novel cyclic alpha-amino esters via 1-pot sequential Petasis reaction/palladium catalysed processes. Tetrahedron Letters 44 -, 2003

Bruyere D; Grigg RE; Hinsley J; Hussain RK; Orgaz de la Cierva C; Wang J; Sridharan V; Korn S Highly regioselective palladium/copper-catalysed cross-coupling reactions of terminal alkynes and allenes. Tetrahedron Letters 44 8669-8672, 2003
DOI:10.1016/j.tetlet.2003.09.160

Cooper I; Grigg RE; MacLachlan WS; Sridharan V; Thornton-Pett MA Diastereo- and Regio-Selective Palladium– Indium Bimetallic Cyclisation – Barbier type Allylation Cascades. Tetrahedron Letters 44 403-405, 2003
DOI:10.1016/S0040-4039(02)02428-0

Grigg RE; Savic V; Terrier C; Sridharan V Palladium catalysed queuing processes. Part 4: Termolecular cyclisation-anion capture cascades employing allene as a relay switch and secondary amines as nucleophiles Tetrahedron 58 8613-8620, 2002
DOI:10.1016/S0040-4020(02)00763-9

von Seebach M; Grigg RE; deMeijere A Multicomponent queuing cascades of bicyclopropylidene, carbon monoxide and aryl iodides or aryl thiols European Journal of Organic Chemistry 3268-3275, 2002
DOI:10.1002/1099-0690(200210)2002:19<3268::AID-EJOC3268>3.0.CO;2-H

Dunn PJ; Graham AB; Grigg RE; Saba IS; Thornton-Pett MA X=Y-ZH systems as potential 1,3 diploles. Part 55; Cascade 1,3 azaprotio cyclotransfer-cycloaddition reactions between ketoximes and divinyl ketone Tetrahedron 58 7701-7713, 2002
DOI:10.1016/S0040-4020(02)00834-7

Blackwell M; Dunn PJ; Graham AB; Grigg RE; Higginson P; Saba IS; Thornton-Pett MA X=Y-ZH systems as potential 1,3-dipoles. part 56: Cascade 1,3-azaprotio cyclotransfer-cycloaddition reactions between aldoximes and divinyl ketone: the effect of oxime E/Z isomerisation on cycloaddition stereoselectivity Tetrahedron 58 7715-7725, 2002
DOI:10.1016/S0040-4020(02)00835-9

Dunn PJ; Graham AB; Grigg RE; Higginson P; Thornton-Pett MA X=Y-ZH systems as potential 1,3-dipoles. Part 57: Cascade 1,3-azaprotio cyclotransfer-cycloaddition reactions between aldoximes and divinyl ketone: remarkable rate enhancement and control of cycloaddition regiochemistry by Lewis acids Tetrahedron 58 7727-7733, 2002
DOI:10.1016/S0040-4020(02)00836-0

Aftab T; Grigg RE; Ladlow M; Sridharan V; Thornton-Pett MA Novel synthesis of fused isoxazolidines via a palladium catalysed allene insertion-intramolecular 1,3-dipolar cycloaddition cascade reaction Chemical Communications 1754-1755, 2002
DOI:10.1039/b205069b

Dondas HA; Grigg RE; Thibault S; Thomas WA; Thornton-Pett MA X=Y-ZH systems as potential 1,3-dipoles. Part 54: Stereo-and facially selective formation of bridged bicyclic N-heterocycles via a sequential one pot electrophile induced oxime ->nitrone ->cycloaddition sequence. Multiplication of chirality Tetrahedron 58 5827-5836, 2002
DOI:10.1016/S0040-4020(02)00564-1

Blaney P; Grigg RE; Sridharan V Traceless solid-phase organic synthesis Chemical Reviews 102 2607-2624, 2002
DOI:10.1021/cr0103827

Grigg RE; Millington E; Thornton-Pett MA Spiro-oxindoles via bimetallic Pd(0)/Ag(I) catalytic intramolecular Heck-1,3-dipolar cycloaddition cascade reactions Tetrahedron Letters 43 2605-2608, 2002
DOI:10.1016/S0040-4039(02)00331-3

Grigg RE; Khamnaen T; Rajviroongit S; Sridharan V Synthesis of N-substituted 4-methylene-3,4-dihydro-1(2H)- isoquinolin-1-ones via a palladium-catalysed three-component process Tetrahedron Letters 43 2601-2603, 2002
DOI:10.1016/S0040-4039(02)00329-5

Grigg RE; Sridharan V; Thornton-Pett MA; Wang J; Xu J; Zhang J Kinetic acidity of iminium ions. 2-Alkynyl- and 2,5- dialkynylpyrrolidines via the iminium ion route to azomethine ylides Tetrahedron 58 2627-2640, 2002
DOI:10.1016/S0040-4020(02)00129-1

Blaney P; Grigg RE; Rankovic Z; Thornton-Pett MA; Xu J Fused and bridged bi- and tri-cyclic lactams via sequential metallo-azomethine ylide cycloaddition-lactamisation Tetrahedron 58 1719-1737, 2002
DOI:10.1016/S0040-4020(02)00029-7

Cooper IR; Grigg RE; MacLachlan WS; Thornton-Pett MA; Sridharan V 3-Component palladium-indium mediated diastereoselective cascade allylation of imines with allenes and aryl iodides Chemical Communications 1372-1373, 2002
DOI:10.1039/b202940e

Grigg RE; Kongathip N; Kongathip B; Luangkamin S; Dondas HA Palladium catalysed reactions of allene with active methylene pronucleophiles. C-1,3-dienylmethyl derivatives and their Diels-Alder reactions Tetrahedron 57 9187-9197, 2002

Dondas AH; Grigg RE; Markandu J; Perrior T; Suzuki T; Thibault S; Thomas WA; Thornton-Pett MA Stereoselective electrophile-induced mono- and bis-cyclisation- fragmentation reactions of alkenyl oxime O-allyl and O-benzyl ethers. Synthesis of dihydropinidine Tetrahedron 58 161-173, 2002
DOI:10.1016/S0040-4020(01)01118-8

Bohmer J; Grigg RE; Marchbank J Diastereoselective cascade synthesis of azabicyclo 3.1.0 hexanes from acyclic precursors Chemical Communications 768-769, 2002
DOI:10.1039/b110890e

Grigg RE; Mariani E; Sridharan V Palladium-catalysed in situ zipper generation-cyclisation-anion capture. Synthesis of 3,3-disubstituted indolines and 2,3- dihydrobenzofurans Tetrahedron Letters 42 8677-8680, 2001
DOI:10.1016/S0040-4039(01)01811-1

Dondas HA; Balme G; Clique B; Grigg RE; Hodgeson A; Morris J; Sridharan V Synthesis of heterocycles via sequential Pd/Ru-catalysed allene insertion-nucleophile incorporation-olefin metathesis Tetrahedron Letters 42 8673-8675, 2001
DOI:10.1016/S0040-4039(01)01810-X

Grigg RE; Kongathip N; Kongathip B; Luangkamin S; Dondas HA Palladium catalysed reactions of allene with active methylene pronucleophiles. C-1,3-dienylmethyl derivatives and their Diels-Alder reactions Tetrahedron 57 9187-9197, 2001
DOI:10.1016/S0040-4020(01)00924-3

Dunn PJ; Graham AB; Grigg RE; Higginson P; Sridharan V; Thornton-Pett MA A novel route to substituted 4-methylene-4,5-dihydroisoxazoles mediated by hafnium(IV) chloride Chemical Communications 1968-1969, 2001
DOI:10.1039/b105561p

Gai X; Grigg RE; Collard S; Muir JE Palladium catalysed 3-component cascade synthesis of bis(2- arylallyl) tertiary amines from aryl iodides, allene and primary amines Chemical Communications 1712-1713, 2001
DOI:10.1039/b105567b

Fielding M; Grigg RE; Sridharan V; Thornton-Pett MA; Urch CJ Sequential oxopyridinium betaine cycloaddition-palladium catalysed cyclisation-anion capture processes Tetrahedron 57 7737-7748, 2001
DOI:10.1016/S0040-4020(01)00740-2

Grigg RE; Kongathip N; Kongathip B; Luangkamin S; Dondas HA Palladium catalysed reaction of allene with phenols. Phenoxymethyl-1,3-dienes and their further reactions Tetrahedron 57 7965-7978, 2001
DOI:10.1016/S0040-4020(01)00771-2

Grigg RE; Jones MF; McTiernan M; Sridharan V Sequential decarboxylative azomethine ylide cycloaddition- palladium catalysed hydrostannylation-cyclisation-anion capture processes Tetrahedron 57 7979-7989, 2001
DOI:10.1016/S0040-4020(01)00772-4

Gardiner M; Grigg RE; Kordes M; Sridharan V; Vicker N One-pot sequential and cascade formation of triazoles via palladium catalysed azide capture-1,3-dipolar cycloaddition Tetrahedron 57 7729-7735, 2001
DOI:10.1016/S0040-4020(01)00737-2

Dondas AH; Cummins J; Grigg RE; Thornton-Pett MA X=Y-ZH systems as potential 1,3-dipoles. Part 53: Sequential nucleophilic ring opening- 1,3-dipolar cycloaddition reactions of Z-oxime anions with aziridines and dipolarophiles Tetrahedron 57 7951-7964, 2001
DOI:10.1016/S0040-4020(01)00767-0

Casas J; Grigg RE; Najera C; Sansano J The effect of phase-transfer catalysis in the 1,3-dipolar cycloaddition reactions of azomethine ylides - Synthesis of substituted prolines using AgOAc and inorganic base in substoichiometric amounts European Journal of Organic Chemistry 1971-1982, 2001
DOI:10.1002/1099-0690(200105)2001:10<1971::AID-EJOC1971>3.0.CO;2-U

Brown S; Clarkson S; Grigg RE; Thomas WA; Sridharan V; Wilson DM Palladium catalysed queuing processes. Part 1: Termolecular cyclization-anion capture employing carbon monoxide as a relay switch and hydride, organotin(IV) or boron reagents Tetrahedron 57 1347-1359, 2001
DOI:10.1016/S0040-4020(00)01103-0

Dondas AH; Grigg RE; Hadjisoteriou M; Markandu J; Kennewell P; Thornton-Pett MA X=Y-ZH Systems as potential 1,3-dipoles. Part 51: Halogen- induced inter- and intra-molecular formation of nitrones from oximes and alkenes Tetrahedron 57 1119-1128, 2001
DOI:10.1016/S0040-4020(00)01084-X

Anwar U; Casaschi A; Grigg RE; Sansano J Palladium catalysed queuing processes. Part 2: Termolecular cyclization-anion capture employing carbon monoxide as a relay switch with in situ generated vinylstannanes Tetrahedron 57 1361-1367, 2001
DOI:10.1016/S0040-4020(00)01104-2

Grigg RE; Kordes M Synthesis of cyclopropanes by intramolecular attack of N- nucleophiles on the central carbon of (pi-allyl)palladium complexes European Journal of Organic Chemistry 707-712, 2001
DOI:10.1002/1099-0690(200102)2001:4<707::AID-EJOC707>3.0.CO;2-I

Grigg RE; MacLachlan WS; McPherson DT; Sridharan V; Suganthan S Palladium catalysed tandem cyclisation - anion capture. Part 8 cascade hydrostannylation - cyclisation - anion capture and cascade hydroboration - palladium cataylsed cyclisation - anion capture on solid phase. Tetrahedron 57 10335-10345, 2001
DOI:10.1016/S0040-4020(01)01061-4

Gai X; Grigg RE; Collard S; Muir JE Palladium catalysed 3-component cascade synthesis of bis(2-arylallyl) tertiary amines from aryl iodides, allene and primary amines Chemical Communications 1712-1713, 2001
DOI:10.1039/b105567b

Grigg RE; Koppen I; Rasparini M; Sridharan V Synthesis of spiro- and fused heterocycles by palladium catalysed carbo- and heteroannulation cascades of allenes Chemical Communications 964-965, 2001
DOI:10.1039/b102046n

Grigg RE; Kordes M Cyclopropanes by Intramolecular Attack of N-Nucleophiles on the central cCarbon of pi-Allyl palladium complexes European Journal of Organic Chemistry 707-712, 2001
DOI:10.1002/1099-0690(200102)2001:4<707::AID-EJOC707>3.0.CO;2-I

Brown S; Grigg RE; Hinsley J; Korn S; Sridharan V; Uttley MD Three - Component Heck - Diels - Alder processes involving alkylallenes, aryl/heteroaryl iodides and dienophiles. Tetrahedron 57 10347-10355, 2001
DOI:10.1016/S0040-4020(01)01062-6

Casaschi A; Grigg RE; Sansano J Palladium catalysed tandem cyclisation-anion capture. Part 7: Synthesis of derivatives of alpha-amino esters, nitrogen heterocycles and beta-aryl/heteroaryl ethylamines via in situ generated vinylstannanes Tetrahedron 57 607-615, 2001
DOI:10.1016/S0040-4020(00)01030-9

Grigg RE; MacLachlan WS; McPherson DT; Sridharan V; Suganthan S Palladium catalysed tandem cyclisation-anion capture. Part 8: Cascade hydrostannylation-cyclisation-anion capture and cascade hydroboration - palladium catalysed cyclisation - anion capture on solid phase Tetrahedron 57 10335-10345, 2001
DOI:10.1016/S0040-4020(01)01061-4

Dondas HA; Grigg RE; Thibault S X=Y-ZH systems as potential 1,3-dipoles. Part 52. Fused ring forming electrophile induced oxime - nitrone - cycloaddition cascades Tetrahedron 7035-7045, 2001
DOI:10.1016/S0040-4020(01)00661-5

Dondas HA; Grigg RE; Hadjisoteriou M; Markandu J; Thomas WA; Kennewell P XY-ZH systems as potential 1,3-dipoles. Part 50:1phenylselenyl halide induced formation of cyclic nitrones from alkenyl oximes Tetrahedron 56 10087-10096, 2000

Dondas HA; Grigg RE; MacLachlan WS; MacPherson DT; Markandu J; Sridharan V; Suganthan S Solid phase sequential 1,3-dipolar cycloaddition pictet spengler reactions. Tetrahedron Letters 41 967-970, 2000

Grigg RE; MacLachlan WS; Rasparini M Palladium catalysed tetramolecular queuing cascades of aryl iodides, carbon monoxide, amines and a polymer supported allene Chemical Communications 2241-2242, 2000

Grigg RE; Blaney P; Rankovic Z; Thoroughgood M Application of Grignard Reagents to the Synthesis of Tertiary Methylamines via Resin-Bound Oxyiminium Ions Tetrahedron Letters 41 6639-6642, 2000

Brown S; Clarkson S; Grigg RE; Thomas WA; Sridharan V; Wilson DM Palladium Catalysed Queuing Processes. Part 1. Termolecular Cyclisation Anion-Capture Employing Carbon Monoxide as a relay switch and hydride, organotin (IV) or boron reagents. Tetrahedron -, 2000

Anwar U; Grigg RE; Sridharan V Palladium catalysed cyclisation-barbier-type allylation cascades Chemical Communications 11 933-934, 2000

Gai X; Grigg RE; Ramzan M; Sridharan V; Collard S; Muir J Pyrazole and benzothiazole palladacycles: Stable and efficient catalysts for carbon-carbon bond formation. Chemical Communications 20 2053-2054, 2000

Grigg RE; Sridharan V; Zhang J Sequential One-Pot Rh(I)/Pd(0) Catalysed Cycloaddition-Cyclisation-Anion Capture. Assembly of polyfunctional compounds Tetrahedron Letters 40 8277-8280, 1999

Evans P; Grigg RE; Ramzan M; Sridharan V; York M Sequential and cascade palladium catalysed cyclisation-anion capture-olefin metathesis Tetrahedron Letters 40 3021-3024, 1999

Grigg RE; Sridharan V Palladium catalysed cascade cyclisation-anion capture, relay switches and molecular queues Journal of Organometallic Chemistry 576 65-87, 1999

Grigg RE; Sridharan V Heterocycles via Pd catalysed molecular queuing processes. Relay switches and maximisation of molecular complexity. Pure and Applied Chemistry 70 1047-1057, 1998

Grigg RE; Brown S; Sridharan V; Uttley MD Palladium catalysed tetramolecular cascade processes in corporating allene and carbon monoxide Tetrahedron Letters 38 5031-5034, 1997

Grigg RE; Dondas HA; Fishwick CWG; Thornton-Pett MA X=Y-ZH Systems as Potential 1,3-Dipoles. Part 60. Cycloaddition of Azomethine Ylides Derived from Uracil Polyoxin C (UPoC): Acess to Nikkomycin Analogues. Tetrahedron -,

Grigg RE; Holloway S; McDonald S; Sarkar M X = Y– ZH Systems as Potential 1, 3-Dipoles. Part 61. Metal Exchanged Zeolites, Silver Oxide, Ni(II) and Cuprous Iodide as Catalysts for 1, 3-Dipolar Cycloaddition Reactions of Imines. Tetrahedron -,

Grigg RE; Evans P; Wolstenholme-Hogg PC; Nurnabi M; Hinsley J; Sridharan V; Suganthan S; Collard S; Korn S; Muir JE 8-Methylquinoline Palladacycles: Stable and Efficient Catalysts for Carbon-Carbon Bond Formation. Chemical Communications -,

Grigg RE; Fishwick CWG; Kilner CA; Dondas HA X = Y– ZH Systems as potential 1, 3 – dipoles. Part 59. Cascade 1, 3 – Azaprotio cyclotransfer – 1, 3 – Dipolar cycloaddition ( 1, 3 – APT – 1, 3 – DC ) Reactions of Benzobicyclo [ 3.3.1 ] non – 5 – en – 9 – one Oxime. Tetrahedron -,

Grigg RE; Gai X; Gao C; Collard S; Muir JE Synthesis of 4-Methylene-1, 2, 3, 4-Tetrahydroisoquinolines via Palladium Catalysed 3-Component Cascade Heteroanulation Tetrahedron Letters -,

Grigg RE; Bruyere D; Hinsley J; Hussain RK; Korn S; Orgaz de la Cierva C; Sridharan V; Wang J Highly Regioselective Palladium/Copper-Catalysed Cross Coupling Reactions of Terminal Alkynes and Allenes. Tetrahedron Letters -,

Grigg RE; Cleghorn L; Cooper IR; MacLachlan WS; Rasparini M; Sridharan V 3– Component Bimetallic ( Pd/In) Mediated Cascade Allylation of C = X Functionality. Part 1. Scope and Class 1 Examples. Journal of Organometallic Chemistry -,