School of Chemistry

Richard Foster

MCCB Technology Group Leader
Research section: Organic Chemistry

Contact details

Keywords

Medicinal chemistry
Virtual drug design
Chemical genetics
Combinatorial chemistry

Research interests

My research interests lie in the design, synthesis and optimisation of small molecules for therapeutic application or their use in the elucidation of biological function. By combining tools and techniques in medicinal chemistry, high-throughput screening, combinatorial chemistry, and computational-aided drug design we aim to identify and optimise targeted small molecules as key modulators of specific biological function. These multidisciplinary projects form part of collaborative frameworks with scientists and clinicians from a variety of backgrounds both within the university and from outside.

Useful links

Current Research   
   
   

Selected publications

Preparation of substituted imidazoheterocycles, particularly 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazines and 6,7,8,9-tetrahydroimidazo[1,5-a][1,4]diazepines, as cannabinoid receptor modulators. US 2011003444.

Orai1 and CRAC channel dependence of VEGF-activated Ca2+-entry andendothelial tube formation. Circulation Research, 2011, 108, 1190-1198.

Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus (HCV) p7 ion channel. Hepatology, 2011, 54(1), 79-90.

Substituted Imidazoheterocycles as Cannabinoid Receptor Modulators. Richard Foster et al. WO2008157751