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Richard Foster

Medicinal Chemistry Group Leader
Member of the Chemical Biology and Medicinal Chemistry group

Contact details

Room: 1.18
Tel: +44 (0)113 3435759
Email: R.Foster@leeds.ac.uk

Keywords

Medicinal chemistry
Virtual drug design
Chemical genetics
Combinatorial chemistry


Photograph of Richard Foster

Research interests

Our group undertakes research in medicinal chemistry, synthetic chemistry and chemical biology. The underlying focus of our research is small molecule drug discovery. We are interested in the synthesis and development of small molecules as therapeutics as well as the design of chemical probes to support validation of novel biological targets in areas of unmet medical need.

Useful links

Research group   
   
   

Publications

Schumann S, Jackson BR, Yule I, Whitehead SK, Revill C, Foster R, Whitehouse A Targeting the ATP-dependent formation of herpesvirus ribonucleoprotein particle assembly as an antiviral approach Nature Microbiology 2 -, 2016
DOI:10.1038/nmicrobiol.2016.201
View abstract

Bailey MA, Rode B, Gosain R, Bridge KI, Griffin KJ, Shires M, Porter KE, Plein S, Wheatcroft SB, Foster R, Scott DJA, Beech DJ PATHOLOGICAL VASCULAR SMOOTH MUSCLE CELLS REMODELLING IN MURINE MODELS OF ABDOMINAL AORTIC ANEURYSM HEART 102 , 2016
DOI:10.1136/heartjnl-2016-310696.16

Read C, Fitzpatrick CM, Yang P, Kuc RE, Maguire JJ, Glen RC, Foster RE, Davenport AP Cardiac action of the first G protein biased small molecule apelin agonist Biochemical Pharmacology 116 63-72, 2016
DOI:10.1016/j.bcp.2016.07.018
View abstract

Walter S, Bollenbach A, Doerrbecker J, Pfaender S, Brown RJP, Vieyres G, Scott C, Foster R, Kumar A, Zitzmann N, Griffin S, Penin F, Pietschmann T, Steinmann E Ion channel function and cross-species determinants in viral assembly of nonprimate hepacivirus p7 Journal of Virology 90 5075-5089, 2016
DOI:10.1128/JVI.00132-16
View abstract

Saunders JC, Young LM, Mahood RA, Jackson MP, Revill CH, Foster RJ, Smith DA, Ashcroft AE, Brockwell DJ, Radford SE An in vivo platform for identifying inhibitors of protein aggregation Nature Chemical Biology 12 94-101, 2016
DOI:10.1038/nchembio.1988
View abstract

Young LM, Saunders JC, Mahood RA, Revill CH, Foster RJ, Ashcroft AE, Radford SE ESI-IMS-MS: A method for rapid analysis of protein aggregation and its inhibition by small molecules Methods 95 62-69, 2016
DOI:10.1016/j.ymeth.2015.05.017
View abstract

Fisher MJ, Williamson DJ, Burslem GM, Plante JP, Manfield IW, Tiede C, Ault JR, Stockley PG, Plein S, Maqbool A, Tomlinson DC, Foster R, Warriner SL, Bon RS Trivalent Gd-DOTA reagents for modification of proteins RSC Advances 5 96194-96200, 2015
DOI:10.1039/c5ra20359g
View abstract

Li J, Bruns A-F, Hou B, Rode B, Webster PJ, Bailey MA, Appleby HL, Moss NK, Ritchie JE, Yuldasheva NY, Tumova S, Quinney M, McKeown L, Taylor H, Prasad KR, Burke D, O'Regan D, Porter KE, Foster R, Kearney MT, Beech DJ Orai3 Surface Accumulation and Calcium Entry Evoked by Vascular Endothelial Growth Factor Arteriosclerosis, Thrombosis, and Vascular Biology 35 1987-1994, 2015
DOI:10.1161/ATVBAHA.115.305969
View abstract

Wishart C, Hardy L, Corte ACL, Hethershaw E, Revill C, Fishwick C, Foster R, Ariens R, Philippou H surface plasmon resonance: SensiQ Pioneer as a means to screen drug discovery fragments for HITS JOURNAL OF THROMBOSIS AND HAEMOSTASIS 13 574-574, 2015

Bridge KI, Revill C, Bailey M, Yuldasheva N, Wheatcroft S, Butlin R, Foster R, Scott J, Gils A, Ariens R Inhibition of TAFI affects AAA formation and rupture in the angiotensin II model of abdominal aortic aneurysm JOURNAL OF THROMBOSIS AND HAEMOSTASIS 13 73-73, 2015

Colomer I, Adeniji O, Burslem GM, Craven P, Rasmussen MO, Willaume A, Kalliokoski T, Foster R, Marsden SP, Nelson A Aminomethylhydroxylation of alkenes: Exploitation in the synthesis of scaffolds for small molecule libraries Bioorganic and Medicinal Chemistry 23 2736-2740, 2015
DOI:10.1016/j.bmc.2015.01.058
View abstract

Craven P, Aimon A, Dow M, Fleury-Bregeot N, Guilleux R, Morgentin R, Roche D, Kalliokoski T, Foster R, Marsden SP, Nelson A Design, synthesis and decoration of molecular scaffolds for exploitation in the production of alkaloid-like libraries Bioorganic and Medicinal Chemistry 23 2629-2635, 2015
DOI:10.1016/j.bmc.2014.12.048
View abstract

Firth JD, Zhang R, Morgentin R, Guilleux R, Kalliokoski T, Warriner S, Foster R, Marsden SP, Nelson A Exploitation of the Ugi-Joullié Reaction in the Synthesis of Libraries of Drug-Like Bicyclic Hydantoins Synthesis (Germany) 47 2391-2406, 2015
DOI:10.1055/s-0034-1378704
View abstract

Bailey MA, Rode B, Simpson CM, Green BL, Plante J, Foster R, Young R, Li J, Porter KE, Scott DJA, Beech DJ Functional significance of the novel CRAC channel inhibitor, JPIII in abdominal aortic aneurysm vascular smooth muscle cells BRITISH JOURNAL OF SURGERY 102 10-10, 2015

Bailey MA, Simpson CM, Green BL, Foster R, Porter KE, Scott DJA, Beech DJ Orai1 is a viable drug target in abdominal aortic aneurysm BRITISH JOURNAL OF SURGERY 102 12-12, 2015

Young LM, Saunders JC, Mahood RA, Revill CH, Foster RJ, Tu LH, Raleigh DP, Radford SE, Ashcroft AE Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry-mass spectrometry Nature Chemistry 7 73-81, 2015
DOI:10.1038/nchem.2129
View abstract

Appleby H, Gaunt H, Jansz S, Hyman A, Stokes O, Young R, Foster R, Beech D Resistance of store-operated calcium entry to tumour microenvironment conditions and enhanced potency of Synta66 in colorectal adenocarcinoma cells FASEB JOURNAL 28 -, 2014

Bailey M, Young R, Rode B, Foster R, Li J, Beech D Significance of store operated calcium entry in human abdominal aortic aneurysm vascular smooth muscle cells FASEB JOURNAL 28 -, 2014

Foster TL, Thompson GS, Kalverda AP, Kankanala J, Bentham M, Wetherill LF, Thompson J, Barker AM, Clarke D, Noerenberg M, Pearson AR, Rowlands DJ, Homans SW, Harris M, Foster R, Griffin S Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release Hepatology 59 408-422, 2014
DOI:10.1002/hep.26685
View abstract

Wetherill LF, Holmes K, Verow M, Muller M, Howell M, Harris M, Fishwick C, Stonehouse N, Foster R, Blair E, Griffin S, Macdonald A High-risk papillomavirus E5 oncoprotein displays channel-forming activity sensitive to small molecule inhibitors Journal of Virology 86 5341-5351, 2012
DOI:10.1128/JVI.06243-11
View abstract

Li J, McKeown L, Ojelabi O, Stacey M, Foster R, O apos Regan D, Porter KE, Beech DJ Nanomolar potency and selectivity of a Ca 2+ release-activated Ca 2+ channel inhibitor against store-operated Ca 2+ entry and migration of vascular smooth muscle cells British Journal of Pharmacology 164 382-393, 2011
DOI:10.1111/j.1476-5381.2011.01368.x
View abstract

Foster TL, Verow M, Wozniak AL, Bentham MJ, Thompson J, Atkins E, Weinman SA, Fishwick C, Foster R, Harris M, Griffin S Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel Hepatology 54 79-90, 2011
DOI:10.1002/hep.24371
View abstract

Foster TL, Verow M, Wozniak M, Bentham M, Thompson J, Atkins E, Weinman S, Fishwick CWG, Foster RJ, Harris M, Griffin S Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus (HCV) p7 ion channel Hepatology 54 79-90, 2011

Li J, McKeown L, Ojelabi O, Stacey M, Foster R, Porter K, Beech DJ Nanomolarpotency and selectivity of a CRAC channel blocker against store-operated Ca2+-entry and migration of vascular smooth muscle cells British Journal of Pharmacology 164 382-393, 2011

Li J, Cubbon R, Wilson L, Amer M, McKeown L, Hou B, Majeed Y, Tumova S, Semour V, Taylor H, Stacey M, Foster R, Porter K, Kearney M, Beech DJ Orai1 and CRAC channel dependence of VEGF-activated Ca2+-entry andendothelial tube formation Circulation Research 108 1190-1198, 2011

Stephens P, Hunter C, Bignell G, Edkins S, Davies H, Teague J, Stevens C, O'Meara S, Smith R, Parker A, Barthorpe A, Blow M, Brackenbury L, Butler A, Clarke O, Cole J, Dicks E, Dike A, Drozd A, Edwards K, Forbes S, Foster R, Gray K, Greenman C, Halliday K, Hills K, Kosmidou V, Lugg R, Menzies A, Perry J, Petty R, Raine K, Ratford L, Shepherd R, Small A, Stephens Y, Tofts C, Varian J, West S, Widaa S, Yates A, Brasseur F, Cooper CS, Flanagan AM, Knowles M, Leung SY, Louis DN, Looijenga LHJ, Malkowicz B, Pierotti MA, Teh B, Chenevix-Trench G, Weber BL, Yuen ST, Harris G, Goldstraw P, Nicholson AG, Futreal PA, Wooster R, Stratton MR, Canc Genome Project Collaborat Grp Intragenic ERBB2 kinase mutations in tumours NATURE 431 525-526, 2004
DOI:10.1038/431525b

Stephens P, Hunter C, Bignell G, Edkins S, Davies H, Teague J, Stevens C, O'Meara S, Smith R, Parker A, Barthorpe A, Blow M, Brackenbury L, Butler A, Clarke O, Cole J, Dicks E, Dike A, Drozd A, Edwards K, Forbes S, Foster R, Gray K, Greenman C, Halliday K, Hills K, Kosmidou V, Lugg R, Menzies A, Perry J, Petty R, Raine K, Ratford L, Shepherd R, Small A, Stephens Y, Tofts C, Varian J, West S, Widaa S, Yates A, Brasseur F, Cooper CS, Flanagan AM, Knowles M, Leung SY, Louis DN, Looijenga LHJ, Malkowicz B, Pierotti MA, Teh B, Chenevix-Trench G, Weber BL, Yuen ST, Harris G, Goldstraw P, Nicholson AG, Futreal PA, Wooster R, Stratton MR, Grp CGPC Intragenic ERBB2 kinase mutations in tumours NATURE 431 525-526, 2004
DOI:10.1038/431525b

Foster RJ, Carr RE, Fishwick CWG Cyclic-fused azomethine-, imidate-, and thioimidate methylides: An efficient regiocontrolled entry into spiro-fused pyrrolidines TETRAHEDRON LETT 37 5163-5166, 1996

Fishwick CWG, Foster RJ, Carr RE A short dipolar cycloaddition approach to gamma-lactam alkaloids from Cynometra hankei TETRAHEDRON LETT 37 3915-3918, 1996

Foster RJ, Carr RE, Fishwick CWG Hetero-1,3-dipolar cycloadditions of dithiolane-isocyanate iminium methylides: A novel route to 1,3-oxazolidine- and thiazolidine-2-thiones TETRAHEDRON LETT 37 711-714, 1996

Foster RJ, Carr RE, Fishwick CWG Dithiolane-isocyanate imminium methylides: A rapid stereoselective entry into gamma-lactams TETRAHEDRON LETT 36 9409-9412, 1995

Foster RJ Substituted imidazoheterocycle derivatives as cannabinoidreceptor modulators and their preparation, pharmaceutical compositions and use in the treatment of pain,

Foster RJ, Beckett P, Henault C, Rabolvsky J, Gauss J, Gustafson CM, Luo G, Cambell AM, Shelekhin T, Zablocki MM Preparation of substituted imidazoheterocycles, particularly 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazines and 6,7,8,9-tetrahydroimidazo[1,5-a][1,4]diazepines, as cannabinoid receptor modulators,
View abstract

Foster RJ Substituted imidazoheterocycle derivatives as cannabinoid receptor modulators and their preparation, pharmaceutical compositions and use in the treatment of pain,
View abstract

Foster R Kinase Inhibitors,

Foster R Kinase Inhibitors,

Foster R Preparation of Phenylpyrazoles as 5-HT2A Serotonin Receptor Modulators,

Foster R Sulfonamide-based Compounds as Protein Tyrosine Kinase Inhibitors,

Foster R Preparation of Thiazolylpiperidines as Microsomal Triglyceride Transfer Protein (MTP) and/or Apoprotein B (ApoB) Inhibitors Useful in the Treatment of Dyslipidemia and Related Diseases,

Foster R Preparation of Phenylpyrazoles as 5-HT2A Serotonin Receptor Modulators,

Foster R Substituted Azoles,

Foster R Partnering for Successful Informatics Driven Drug Discovery In Genetic Engineering News ,

Foster R Preparation of N-benzodioxolyl, N-benzodioxanyl, and N-benzodioxepinyl arylcarboxamides as Microsomal Triglyceride Transfer Protein (MTP) and/or Apoprotein B (ApoB) Inhibitors Useful in the Treatment of Dyslipidemia,

Foster R Kinase Inhibitors,

Foster R New Pyrazole Derivatives are 5-HT2A Inverse Agonists - Useful for the Treatment of CNS, Gastrointestinal, Cardiovascular and Inflammatory Disorders,

Foster R Kinase Inhibitors,

Foster RJ, Beckett P, Gauss C, Henault C, Gustaffson G Preparation of substituted imidazoheterocycles, particularly 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazines and 6,7,8,9-tetrahydroimidazo[1,5-a][1,4]diazepines, as cannabinoid receptor modulators,