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Colin Fishwick

Professor of Medicinal Chemistry
Member of the Chemical Biology and Medicinal Chemistry group

Contact details

Room: G52a
Tel: +44 (0)113 3436510
Email: C.W.G.Fishwick@leeds.ac.uk

Keywords

Medicinal Chemistry
Synthetic methods
Chemical Biology
Drug design
Molecular Modelling

Photograph of Colin Fishwick

Research interests

Computer-aided design and subsequent synthesis of drug-like molecules directed against important therapeutic targets including antibacterial, antimalarial, antithrombotic, anti-Alzheimer's agents and anti-cancer agents. Development of new synthetic methods based around 1,3-dipolar, and hetero Diels-Alder cycloadditions.
Use of synthetic 'probe' molecules in the study of biological structure and function.

Useful links

Fishwick group pages   
   
   

Publications

McPhillie M, Zhou Y, El Bissati K, Dubey J, Lorenzi H, Capper M, Lukens AK, Hickman M, Muench S, Verma SK, Weber CR, Wheeler K, Gordon J, Sanders J, Moulton H, Wang K, Kim TK, He Y, Santos T, Woods S, Lee P, Donkin D, Kim E, Fraczek L, Lykins J, Esaa F, Alibana-Clouser F, Dovgin S, Weiss L, Brasseur G, Wirth D, Kent M, Hood L, Meunieur B, Roberts CW, Hasnain SS, Antonyuk SV, Fishwick C, McLeod R New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections Scientific Reports 6 -, 2016
DOI:10.1038/srep29179
View abstract

Dondas HA, Hempshall A, Narramore S, Kilner C, Fishwick CWG, Grigg R γ-Carboline AC190 analogues via palladium catalysed allene insertion stereo and regioselective 3- and 5- component cascades Tetrahedron 72 1316-1329, 2016
DOI:10.1016/j.tet.2016.01.025
View abstract

Dondas HA, Hempshall A, Narramore S, Kilner C, Fishwick CWG, Grigg R gamma-Carboline AC190 analogues via palladium catalysed allene insertion stereo and regioselective 3-and 5-component cascades TETRAHEDRON 72 1316-1329, 2016
DOI:10.1016/j.tet.2016.01.025

Naylor J, Minard A, Gaunt HJ, Amer MS, Wilson LA, Migliore M, Cheung SY, Rubaiy HN, Blythe NM, Musialowski KE, Ludlow MJ, Evans WD, Green BL, Yang H, You Y, Li J, Fishwick CWG, Muraki K, Beech DJ, Bon RS Natural and synthetic flavonoid modulation of TRPC5 channels British Journal of Pharmacology 173 562-574, 2016
DOI:10.1111/bph.13387
View abstract

Grigg R, Elboray EE, Akkarasamiyo S, Chuanopparat N, Dondas HA, Abbas-Temirek HH, Fishwick CWG, Aly MF, Kongkathip B, Kongkathip N A facile palladium catalysed 3-component cascade route to functionalised isoquinolinones and isoquinolines CHEMICAL COMMUNICATIONS 52 164-166, 2016
DOI:10.1039/c5cc07526b

McPhillie MJ, Cain RM, Narramore S, Fishwick CWG, Simmons KJ Computational methods to identify new antibacterial targets Chemical Biology and Drug Design 85 22-29, 2016
DOI:10.1111/cbdd.12385
View abstract

Shaw J, Harris M, Fishwick CWG Identification of a lead like inhibitor of the hepatitis C virus non-structural NS2 autoprotease Antiviral Research 124 54-60, 2015
DOI:10.1016/j.antiviral.2015.10.001
View abstract

Lolli M, Narramore S, Fishwick CWG, Pors K Refining the chemical toolbox to be fit for educational and practical purpose for drug discovery in the 21st Century Drug Discovery Today 20 1018-1026, 2015
DOI:10.1016/j.drudis.2015.04.010
View abstract

Avery CA, Pease RJ, Smith K, Boothby M, Buckley HM, Grant PJ, Fishwick CWG (±) cis-bisamido epoxides: A novel series of potent FXIII-A inhibitors European Journal of Medicinal Chemistry 98 49-53, 2015
DOI:10.1016/j.ejmech.2015.05.019
View abstract

Latham AM, Kankanala J, Fishwick CW, Ponnambalam S Identification of Receptor Tyrosine Kinase Inhibitors Using Cell Surface Biotinylation and Affinity Isolation. Methods in molecular biology (Clifton, N.J.) 1332 121-131, 2015
DOI:10.1007/978-1-4939-2917-7_8
View abstract

Kime L, Vincent HA, Gendoo DMA, Jourdan SS, Fishwick CWG, Callaghan AJ, McDowall KJ The first small-molecule inhibitors of members of the ribonuclease E family Scientific Reports 5 8028-, 2015
DOI:10.1038/srep08028
View abstract

Shaw J, Fishwick CWG, Harris M Epoxide based inhibitors of the hepatitis C virus non-structural 2 autoprotease Antiviral Research 117 20-26, 2015
DOI:10.1016/j.antiviral.2015.02.005
View abstract

Latham AM, Kankanala J, Fearnley GW, Gage MC, Kearney MT, Homer-Vanniasinkam S, Wheatcroft SB, Fishwick CWG, Ponnambalam S In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis PLoS ONE 9 -, 2014
DOI:10.1371/journal.pone.0110997
View abstract

Yule IA, Czaplewski LG, Pommier S, Davies DT, Narramore SK, Fishwick CWG Pyridine-3-carboxamide-6-yl-ureas as novel inhibitors of bacterial DNA gyrase: Structure based design, synthesis, SAR and antimicrobial activity European Journal of Medicinal Chemistry 86 31-38, 2014
DOI:10.1016/j.ejmech.2014.08.025
View abstract

Simmons KJ, Jackson SM, Brueckner F, Patching SG, Beckstein O, Ivanova E, Geng T, Weyand S, Drew D, Lanigan J, Sharples DJ, Sansom MS, Iwata S, Fishwick CW, Johnson AP, Cameron AD, Henderson PJ Molecular mechanism of ligand recognition by membrane transport protein, Mhp1 The EMBO Journal 33 1831-1844, 2014
DOI:10.15252/embj.201387557
View abstract

Cain R, Narramore S, McPhillie M, Simmons K, Fishwick CWG Applications of structure-based design to antibacterial drug discovery BIOORGANIC CHEMISTRY 55 69-76, 2014
DOI:10.1016/j.bioorg.2014.05.008

Lolicato M, Bucchi A, Arrigoni C, Zucca S, Nardini M, Schroeder I, Simmons K, Aquila M, DiFrancesco D, Bolognesi M, Schwede F, Kashin D, Fishwick CW, Johnson AP, Thiel G, Moroni A Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness Nature Chemical Biology 10 457-462, 2014
DOI:10.1038/nchembio.1521
View abstract

Cookson NJ, Henkelis JJ, Ansell RJ, Fishwick CW, Hardie MJ, Fisher J Encapsulation of sodium alkyl sulfates by the cyclotriveratrylene-based, [Pd(6)L(8)](12+) stella octangula cage. Dalton Trans 43 5657-5661, 2014
DOI:10.1039/c4dt00237g
View abstract

Fisher M, Basak R, Kalverda AP, Fishwick CW, Turnbull WB, Nelson A Discovery of novel FabF ligands inspired by platensimycin by integrating structure-based design with diversity-oriented synthetic accessibility. Org Biomol Chem 12 486-494, 2014
DOI:10.1039/c3ob41975d
View abstract

Cunningham F, McPhillie MJ, Johnson AP, Fishwick CW An in silico structure-based approach to anti-infective drug discovery. Parasitology 141 17-27, 2014
DOI:10.1017/S0031182013000693
View abstract

Lloyd AJ, Potter NJ, Fishwick CWG, Roper DI, Dowson CG Adenosine Tetraphosphoadenosine Drives a Continuous ATP-Release Assay for Aminoacyl-tRNA Synthetases and Other Adenylate-Forming Enzymes ACS Chemical Biology 8 2157-2163, 2013
DOI:10.1021/cb400248f
View abstract

van Berkel SS, Brem J, Rydzik AM, Salimraj R, Cain R, Verma A, Owens RJ, Fishwick CWG, Spencer J, Schofield CJ Assay platform for clinically relevant metallo-beta-lactamases Journal of Medicinal Chemistry 56 6945-6953, 2013
DOI:10.1021/jm400769b
View abstract

Smith KA, Pease RJ, Avery CA, Brown JM, Adamson PJ, Cooke EJ, Neergaard-Petersen S, Cordell PA, Ariëns RA, Fishwick CW, Philippou H, Grant PJ The activation peptide cleft exposed by thrombin cleavage of FXIII-A(2) contains a recognition site for the fibrinogenα chain. Blood 121 2117-2126, 2013
DOI:10.1182/blood-2012-07-446393
View abstract

Simmons KJ, Gotfryd K, Billesbølle CB, Loland CJ, Gether U, Fishwick CW, Johnson AP A virtual high-throughput screening approach to the discovery of novel inhibitors of the bacterial leucine transporter, LeuT. Mol Membr Biol 30 184-194, 2013
DOI:10.3109/09687688.2012.710341
View abstract

Fishwick CWG, Chadwick J, Kellet K, Casas_Arce E, Hooper N, Johnson AP, Mok Y Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design Journal of Medicinal Chemistry 56 1843-1852, 2013
DOI:10.1021/jm301127x
View abstract

Yule IA, Fishwick CWG A simple, one-pot synthesis of N-Alkyl and N-aryl thieno[2,3-d] pyrimidinones from thiophene-and benzothiophene-2-yl-ureas Synthetic Communications 43 337-344, 2013
DOI:10.1080/00397911.2011.596985
View abstract

Wacker SJ, Jurkowski W, Simmons KJ, Fishwick CWG, Johnson AP, Madge D, Lindahl E, Rolland JF, deGroot BL Identification of Selective Inhibitors of the Potassium Channel Kv1.1-1.2(3) by High-Throughput Virtual Screening and Automated Patch Clamp ChemMedChem 7 1775-1783, 2012
DOI:10.1002/cmdc.201100600
View abstract

Bedingfield PT, Cowen D, Acklam P, Cunningham F, Parsons MR, McConkey GA, Fishwick CW, Johnson AP Factors influencing the specificity of inhibitor binding to the human and malaria parasite dihydroorotate dehydrogenases. J Med Chem 55 5841-5850, 2012
DOI:10.1021/jm300157n
View abstract

Kankanala J, Latham AM, Johnson AP, Homer-Vanniasinkam S, Fishwick CW, Ponnambalam S A combinatorial in silico and cellular approach to identify a new class of compounds that target VEGFR2 receptor tyrosine kinase activity and angiogenesis. Br J Pharmacol 166 737-748, 2012
DOI:10.1111/j.1476-5381.2011.01801.x
View abstract

Majeed Y, Tumova S, Green BL, Seymour VA, Woods DM, Agarwal AK, Naylor J, Jiang S, Picton HM, Porter KE, O'Regan DJ, Muraki K, Fishwick CW, Beech DJ Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone. Cell Calcium 51 1-11, 2012
DOI:10.1016/j.ceca.2011.09.005
View abstract

Latham AM, Bruns AF, Kankanala J, Johnson AP, Fishwick CW, Homer-Vanniasinkam S, Ponnambalam S Indolinones and anilinophthalazines differentially target VEGF-A- and basic fibroblast growth factor-mediated responses in primary human endothelial cells. Br J Pharmacol 165 245-259, 2012
DOI:10.1111/j.1476-5381.2011.01545.x
View abstract

McPhillie MJ, Trowbridge R, Mariner KR, O'Neill AJ, Johnson AP, Chopra I, Fishwick CWG Structure-Based Ligand Design of Novel Bacterial RNA Polymerase Inhibitors ACS MED CHEM LETT 2 729-734, 2011
DOI:10.1021/ml200087m

Elboray EE, Grigg R, Fishwick CWG, Kilner C, Sarker MAB, Aly MF, Abbas-Temirek HH X=Y-ZH compounds as potential 1,3-dipoles. Part 65: atom economic cascade synthesis of highly functionalized pyrimidinylpyrrolidines TETRAHEDRON 67 5700-5710, 2011
DOI:10.1016/j.tet.2011.05.074

Smith EL, John S, Abdinejad M, Kankanala J, Fishwick CWG, Philippou E Elucidating novel urokinase-type plasminogen activator inhibitors JOURNAL OF THROMBOSIS AND HAEMOSTASIS 9 819-819, 2011

Mariner K, McPhillie M, Trowbridge R, Smith C, O'Neill AJ, Fishwick CW, Chopra I Activity of and development of resistance to corallopyronin A, an inhibitor of RNA polymerase. Antimicrob Agents Chemother 55 2413-2416, 2011
DOI:10.1128/AAC.01742-10
View abstract

Majeed Y, Amer MS, Agarwal AK, McKeown L, Porter KE, O'Regan DJ, Naylor J, Fishwick CW, Muraki K, Beech DJ Stereo-selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids. Br J Pharmacol 162 1509-1520, 2011
DOI:10.1111/j.1476-5381.2010.01136.x
View abstract

Woon ECY, Zervosen A, Sauvage E, Simmons KJ, Zivec M, Inglis SR, Fishwick CWG, Gobec S, Charlier P, Luxen A, Schofield CJ Structure Guided Development of Potent Reversibly Binding Penicillin Binding Protein Inhibitors ACS MED CHEM LETT 2 219-223, 2011
DOI:10.1021/ml100260x

Mariner KR, Trowbridge R, Agarwal AK, Miller K, O'Neill AJ, Fishwick CW, Chopra I Furanyl-rhodanines are unattractive drug candidates for development as inhibitors of bacterial RNA polymerase. Antimicrob Agents Chemother 54 4506-4509, 2010
DOI:10.1128/AAC.00753-10
View abstract

Majeed Y, Agarwal AK, Naylor J, Seymour VA, Jiang S, Muraki K, Fishwick CW, Beech DJ Cis-isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels. Br J Pharmacol 161 430-441, 2010
DOI:10.1111/j.1476-5381.2010.00892.x
View abstract

Simmons KJ, Chopra I, Fishwick CWG Structure-based discovery of antibacterial drugs NAT REV MICROBIOL 8 501-510, 2010
DOI:10.1038/nrmicro2349

Cowen D, Bedingfield P, McConkey GA, Fishwick CWG, Johnson AP A study of the effects of substituents on the selectivity of the binding of N-arylaminomethylene malonate inhibitors to DHODH BIOORG MED CHEM LETT 20 1284-1287, 2010
DOI:10.1016/j.bmcl.2009.11.079

Miller K, Dunsmore CJ, Leeds JA, Patching SG, Sachdeeva M, Blake KL, Stubbings WJ, Simmons KJ, Henderson PJF, De Los Angeles J, Fishwick CWG, Chopra I Benzothioxalone derivatives as novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferases (MurA and MurZ) Journal of Antimicrobial Chemotherapy 65 2566-2573, 2010
DOI:10.1093/jac/dkq349

Agarwal AK, Fishwick CWG Structure-based design of anti-infectives ANN NY ACAD SCI 1213 20-45, 2010
DOI:10.1111/j.1749-6632.2010.05859.x

Mok NY, Chadwick J, Kellett KAB, Hooper NM, Johnson AP, Fishwick CWG Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening BIOORG MED CHEM LETT 19 6770-6774, 2009
DOI:10.1016/j.bmcl.2009.09.103

StGelais C, Foster TL, Verow M, Atkins E, Fishwick CWG, Rowlands D, Harris M, Griffin S Determinants of Hepatitis C Virus p7 Ion Channel Function and Drug Sensitivity Identified In Vitro J VIROL 83 7970-7981, 2009
DOI:10.1128/JVI.00521-09

Vickers AA, Potter NJ, Fishwick CWG, Chopra I, O'Neill AJ Analysis of mutational resistance to trimethoprim in Staphylococcus aureus by genetic and structural modelling techniques J ANTIMICROB CHEMOTH 63 1112-1117, 2009
DOI:10.1093/jac/dkp090

Davies M, Heikkila T, McConkey GA, Fishwick CWG, Parsons MR, Johnson AP Structure-Based Design, Synthesis, and Characterization of Inhibitors of Human and Plasmodium falciparum Dihydroorotate Dehydrogenases J MED CHEM 52 2683-2693, 2009
DOI:10.1021/jm800963t

Blake KL, O'Neill AJ, Mengin-Lecreulx D, Henderson PJF, Bostock JM, Dunsmore CJ, Simmons KJ, Fishwick CWG, Leeds JA, Chopra I The nature of Staphylococcus aureus MurA and MurZ and approaches for detection of peptidoglycan biosynthesis inhibitors MOL MICROBIOL 72 335-343, 2009
DOI:10.1111/j.1365-2958.2009.06648.x

Johnson AP, Fishwick CWG, McConkey GA, Heikkila T, Davies M, Cowan D, Agarwal A Computational approaches to antibacterial and antimalarial hit finding, 2009

Brozic P, Cesar J, Kovac A, Davies M, Johnson AP, Fishwick CWG, Rizner TL, Gobec S Derivatives of pyrimidine, phthalimide and anthranilic acid as inhibitors of human hydroxysteroid dehydrogenase AKR1C1, 2009
DOI:10.1016/j.cbi.2008.10.019

Sova M, Cadez G, Turk S, Majce V, Polanc S, Batson S, Lloyd AJ, Roper DI, Fishwick CWG, Gobec S Design and synthesis of new hydroxyethylamines as inhibitors of D-alanyl-D-lactate ligase (VanA) and D-alanyl-D-alanine ligase (DdlB) BIOORG MED CHEM LETT 19 1376-1379, 2009
DOI:10.1016/j.bmcl.2009.01.034

Agarwal AK, Johnson AP, Fishwick CWG Synthesis of de novo designed small-molecule inhibitors of bacterial RNA polymerase (vol 64, pg 10049, 2008) TETRAHEDRON 65 1077-1077, 2009
DOI:10.1016/j.tet.2008.11.039

Agarwal AK, Johnson AP, Fishwick CWG Synthesis of de novo designed small-molecule inhibitors of bacterial RNA polymerase TETRAHEDRON 64 10049-10054, 2008
DOI:10.1016/j.tet.2008.08.037

Uppal S, Diggle CP, Carr IM, Fishwick CWG, Ahmed M, Ibrahim GH, Helliwell PS, Latos-Bielenska A, Phillips SEV, Markham AF, Bennett CP, Bonthron DT Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy (vol 40, pg 789, 2008) NAT GENET 40 927-927, 2008

Uppal S, Diggle CP, Carr IM, Fishwick CWG, Ahmed M, Ibrahim GH, Helliwell PS, Latos-Bieleńska A, Phillips SEV, Markham AF, Bennett CP, Bonthron DT Corrigendum: Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy (Nature Genetics (2008) 40, (789-793)) Nature Genetics 40 927-, 2008
DOI:10.1038/ng0708-927c

Uppal S, Diggle CP, Carr IM, Fishwick CWG, Ahmed M, Ibrahim GH, Helliwell PS, Latos-Bielenska A, Phillips SEV, Markham AF, Bennett CP, Bonthron DT Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy NAT GENET 40 789-793, 2008
DOI:10.1038/ng.153

Miller K, Dunsmore CJ, Fishwick CWG, Chopra I Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center ANTIMICROB AGENTS CH 52 1737-1742, 2008
DOI:10.1128/AAC.01015-07

Dunsmore C, Miller K, Blake KL, Patching SG, Henderson PJF, Garnett JA, Stubbings WJ, Phillips SEV, Palestrant DJ, De Los Angeles J, Leeds JA, Chopra I, Fishwick CWG 2-Aminotetralones: Novel inhibitors of MurA and MurZ Bioorganic and Medicinal Chemistry Letters 18 1730-1734, 2008
DOI:10.1016/j.bmcl.2008.01.089
View abstract

Grigg R, Sarkar MRA, Thayaparan A, Sridharan V, Fishwick CWG Pd(0) catalyzed three-five-component C-2-arylallylation of active methylene heterocycles: pyrazolones, oxazolones, isoxazolones and N,N '-dimethylbarbituric acid TETRAHEDRON 63 7213-7228, 2007
DOI:10.1016/j.tet.2007.04.090

Heikkila T, Ramsey C, Davies M, Galtier C, Stead AMW, Johnson AP, Fishwick CWG, Boa AN, McConkey GA Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase J MED CHEM 50 186-191, 2007
DOI:10.1021/jm060687j

Gill JH, Fishwick CWG, Androutsopoulos V, Mohanarajah A, Khamnaen T, Patterson LH, Shnyder SD, Loadman PM, Grigg R Preclinical evaluation of a rationally designed novel class of non-hydroxamate Histone Deacetylase inhibitors (HDACi) EJC SUPPL 4 98-98, 2006

Agarwal AK, Hurdle JG, AlOmar AI, Chopra I, Johnson AP, Fishwick CWG MEDI 326-De Novo design and synthesis of novel RNA polymerase inhibitors as potential anti-tuberculosis agents ABSTR PAP AM CHEM S 232 -, 2006

Davies RPW, Aggeli A, Beevers AJ, Boden N, Carrick LM, Fishwick CWG, McLeish TCB, Nyrkova I, Semenov AN Self-assembling beta-sheet tape forming peptides SUPRAMOL CHEM 18 435-443, 2006
DOI:10.1080/10610270600665855

O'Neill AJ, Huovinen T, Fishwick CWG, Chopra I Molecular Genetic and Structural Modeling Studies of Staphylococcus aureus RNA Polymerase and the Fitness of Rifampin Resistance Genotypes in Relation to Clinical Prevalence Antimicrobial Agents&Chemotherapy 50 298-309, 2006
DOI:10.1128/AAC.50.1.298-309.2006
View abstract

Grigg RE, McCaffrey S, Sridharan V, Fishwick CWG, Kilner CA, Korn S, Bailey K, Blacker J Enantioselective Synthesis of Non-Proteinogenic 2-Arylallylα-Amino Acids via Pd/In Catalytic Cascades. Tetrahedron 62 12159-12171, 2006

Heikkila T, Thirumalairajan S, Davies M, Parsons MR, McConkey AG, Fishwick CWG, Johnson AP The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase BIOORG MED CHEM LETT 16 88-92, 2006
DOI:10.1016/j.bmcl.2005.09.045

Ali MA, Bhogal N, Findlay JB, Fishwick CW The first de novo-designed antagonists of the human NK(2) receptor. J Med Chem 48 5655-5658, 2005
DOI:10.1021/jm050533o
View abstract

Sanderson JM, Findlay JBC, Fishwick CWG Preparation of novel 3H-trifluoromethyldiazirine-based photoactivatable potassium channel antagonists Tetrahedron 61 11244-11252, 2005
DOI:10.1016/j.tet.2005.09.007

Ali MA, Bhogal N, Findlay JBC, Fishwick CWG The First de Novo-Designed Antagonists of the Human NK2receptor Journal of Medicinal Chemistry 48 5655-5658, 2005
DOI:10.1021/jm050533o
View abstract

Besong GE, Bostock JM, Stubbings WJ, Chopra I, Roper DI, Lloyd AJ, Fishwick CWG, Johnson AP A De Novo Designed Inhibitor of D-Ala-D-Ala Ligase from E. coli Angewandte Chemie - International Edition 44 6403-6406, 2005
DOI:10.1002/anie.200501662

Whitehouse C, Fang JY, Aggeli A, Bell M, Brydson RMD, Fishwick CWG, Henderson JR, Knobler CM, Owens RW, Thomson NH, Smith DA, Boden N Adsorption and Self-Assembly of Peptides on Mica Substrates Angewandte Chemie - International Edition 44 1965-1968, 2005
DOI:10.1002/anie.200462160

Fishwick CWG, Mitchell G, Pang PFW Ozonolytic cleavage of 3-oxidopyrilium betaine-derived cycloadducts: Simple and efficient access to stereodefined tetrahydrofurans SYNLETT 285-286, 2005
DOI:10.1055/s-2004-837202

Besong GE, Bostock JM, Stubbings W, Chopra I, Roper DI, Lloyd AJ, Fishwick CWG, Johnson AP A de Novo designed inhibitor of D-Ala-D-Ala ligase from E-coli ANGEW CHEM INT EDIT 44 6403-6406, 2005
DOI:10.1002/.anie.200501662

Whitehouse C, Fang JY, Aggeli A, Bell M, Brydson R, Fishwick CWG, Henderson JR, Knobler CM, Owens RW, Thomson NH, Smith DA, Boden N Adsorption and self-assembly of peptides on mica substrates ANGEW CHEM INT EDIT 44 1965-1968, 2005
DOI:10.1002/anie.200462160

Dondas HA, Fishwick CWG, Gai XJ, Grigg R, Kilner C, Dumrongchai N, Kongkathip B, Kongkathip N, Polysuk C, Sridharan V Stereoselective palladium-catalyzed four-component cascade synthesis of pyrrolidinyl-, pyrazolidinyl-, and isoxazolidinyl isoquinolines ANGEW CHEM INT EDIT 44 7570-7574, 2005
DOI:10.1002/anie.200502066

Dondas HA, Fishwick CWG, Grigg RE, Kilner CA 1, 3-Dipolar cycloaddition of stabilised and non-stabilised azomethine ylides derived from uracil polyoxin C (UPoC): access to nikkomycin anologues Tetrahedron 60 3473-3485, 2004
DOI:10.1016/j.tet.2004.02.028

Dondas HA, Fishwick CWG, Grigg RE, Thornton-Pett M X=Y–ZH system as potential 1,3-dipoles. Part 59: Cascade 1,3-azaprotio cyclotransfer–1,3-dipolar cycloaddition (1,3-APT–1,3-DC) reactions of benzobicyclo[3.3.1]non-5-en-9-one oxime Tetrahedron 59 9997-10007, 2003
DOI:10.1016/j.tet.2003.10.027

Cleghorn L, Cooper IR, Fishwick CWG, Grigg RE, MacLachlan WS, Rasparini M, Sridharan V Three-component bimetallic (Pd/In) mediated cascade allylation of C=X functionality - Part 1. Scope and Class 1 examples with aldehydes and ketones Journal of Organometallic Chemistry 687 483-493, 2003
DOI:10.1016/j.jorganchem.2003.09.047

Fishwick CWG, Beevers AJ, Carrick LM, Whitehouse CD, Aggeli A, Boden N Structures of Helicalβ-Tapes and Twisted Ribbons: The Role of Side-Chain Interactions on Twist and Bend Behavior Nano Letters 3 1475-1479, 2003
DOI:10.1021/nl034095p

Aggeli A, Bell M, Carrick LM, Fishwick CWG, Harding R, Mawer PJ, Radford SE, Strong AE, Boden N pH as a trigger of peptide beta-sheet self-assembly and reversible switching between nematic and isotropic phases J AM CHEM SOC 125 9619-9628, 2003
DOI:10.1021/ja021047i

Fishwick CWG, Grigg R, Sridharan V, Virica J Sequential azomethine imine cycloaddition-palladium catalysed cyclisation processes TETRAHEDRON 59 4451-4468, 2003
DOI:10.1016/S0040-4020(03)00517-9

Horton JR, Bostock JM, Chopra I, Hesse L, Phillips SEV, Adams DJ, Johnson AP, Fishwick CWG Macrocyclic inhibitors of the bacterial cell wall biosynthesis enzyme mur D Bioorganic and Medicinal Chemistry Letters 13 1557-1560, 2003
DOI:10.1016/S0960-894X(03)00176-8

Fishwick CWG, Grigg RE, Dondas HA, Kilner CA X=Y-ZH system as potential 1,3-dipoles. Part 59: Cascade 1,3-azaprotio cyclotransfer-1,3-dipolar cycloaddition (1,3-APT-1,3-DC) reactions of benzobicyclo[3.3.1]non-5-en-9-one Tetrahedron 59 9997-10007, 2003
DOI:10.1016/j.tet.2003.10.027

Ali M, Bhogal N, Fishwick CWG, Findlay JBC Spatial requirements of the antagonist binding site of the NK2receptor Bioorganic and Medicinal Chemistry Letters 11 819-822, 2001
DOI:10.1016/S0960-894X(01)00074-9

Brown GA, Martel SR, Wisedale R, Charmant JPH, Hales NJ, Fishwick CWG, Gallagher T The azomethine ylide strategy for beta-lactam synthesis. An evaluation of alternative pathways for azomethine ylide generation J CHEM SOC PERK T 1 1281-1289, 2001

Brown GA, Martel SR, Planchenault D, Turmes E, Wisedale R, Hales NJ, Fishwick CWG, Gallagher T The Azomethine Ylide Stategy for Beta Lactam Synthesis. An Exploration of Alternative Pathways. Royal Society of Chemistry. Journal: Perkin Transactions 1 1281-1289, 2001

Brown D, Brown GA, Martel SR, Planchenault D, Turmes E, Walsh KE, Wisedale R, Hales NJ, Gallagher T, Fishwick CWG The Azomethine Ylide Strategy for Beta Lactam Synthesis. A Mechanistic Evaluation. Perkin 1. 1270-1280, 2001

Brown D, Brown GA, Martel SR, Planchenault D, Turmes E, Walsh KE, Wisedale R, Hales NJ, Fishwick CWG, Gallagher T The azomethine ylide strategy for beta-lactam synthesis. A comprehensive mechanistic evaluation J CHEM SOC PERK T 1 1270-1280, 2001
DOI:10.1039/b010046n

O'Neill A, Oliva B, Storey CC, Hoyle A, Fishwick CWG, Chopra I RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus International Journal of Antimicrobial Agents and Chemotherapy 44 3163-3166, 2000

Fishwick CWG, Findlay JBC, Sanderson JM, Singh P The synthesis and reactivity of optically pure amino acids bearing side-chain thioamides. Royal Society of Chemistry. Journal: Perkin Transactions 1 19 3227-3231, 2000

Fishwick CWG, Reed JE, Bell AS Facile palladium catalysed functionalisation of 1,2-Isothiazoline-3-ones and the highly diastereoselective diels-alder reactions of 4-vinyl-1,2-isothiazoline-3-one-1-oxides. Tetrahedron 55 12313-12330, 1999

Fishwick CWG, Reed JE, Bell AS Generation and cycloadditions of 2-(N-acylamino)-1-thia-1,3-dienes part III; Control of diastereoselectivity using homochiral auxilaries. Tetrahedron 54 3219-3234, 1998

Fishwick CWG, Singh P, Hurrell CR, Findlay JBC Two novel amino acid derivatives containing side-chain thioamides for the synthesis of photoactivatable peptides. Bioorganic and Medicinal Chemistry Letters 7 715-718, 1997

Fishwick CWG, Foster RJ, Carr RE A short dipolar cycloaddition approach toγ-lactam alkaloids fromcynometra hankei Tetrahedron Letters 37 3915-3918, 1996

Grigg RE, Dondas HA, Fishwick CWG, Thornton-Pett MA X=Y-ZH Systems as Potential 1,3-Dipoles. Part 60. Cycloaddition of Azomethine Ylides Derived from Uracil Polyoxin C (UPoC): Acess to Nikkomycin Analogues. Tetrahedron -,

Brem J, Cain R, Cahill S, McDonough MA, Clifton IJ, Jimenez-Castellanos JC, Avison MB, Sprencer J, Fishwick CWG, Schofield CJ Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin binding protein inhibition by cyclic boronates Nature Communications -,
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