School of Chemistry

Colin Fishwick

Professor of Medicinal Chemistry
Research section: Organic Chemistry

Contact details

Keywords

Medicinal Chemistry
Synthetic methods
Chemical Biology
Drug design
Molecular Modelling

Research interests

Computer-aided design and subsequent synthesis of drug-like molecules directed against important therapeutic targets including antibacterial, antimalerial, antithrombotic, anti-Alzheimer's agents and anti-cancer agents. Development of new synthetic methods based around 1,3-dipolar, and hetero Diels-Alder cycloadditions.
Use of synthetic 'probe' molecules in the study of biological structure and function.

Selected publications

T. Heikkilä, C. Ramsey, M. Davies, C. Galtier, A. M. W. Stead, A. P. Johnson, C. W. G. Fishwick, A. N. Boa, and G. A. McConkey. Inhibitors of Plasmodium Falciparum Dihydroorotate Dehydrogenase as Antiplasmodial Compounds, J. Med. Chem., 2007, 50, 186 – 191

G.E. Besong, J.M Bostock, W. Stubbings, I. Chopra, A.P. Johnson, D.I. Roper, A.J. Lloyd, and C.W.G. Fishwick. A novel de novo designed inhibitor of D-ala-D-ala ligase from E.coli. Angew. Chem. Int. Ed. Engl., 2005, 44, 2 - 6.

T. Heikkila, S. Thrumalairajan, M. Davies, A.P. Johnson, G.McConkey, and C.W.G. Fishwick. The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. Bioorg. Med. Chem. Lett., 2005, 16, 88-92

Julieanne M. Bostock, Ian Chopra, Colin W.G. Fishwick, Lars Hesse, James R. Horton, and Peter Johnson. Macrocyclic Inhibitors of the Bacterial Cell Wall Enzyme MurD. Bioorg. Med. Chem. Lett., 2003, 13, 1557-1560