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Colin Fishwick

Professor of Medicinal Chemistry
Member of the Chemical Biology and Medicinal Chemistry group

Contact details

Room: G52a
Tel: +44 (0)113 3436510


Medicinal Chemistry
Synthetic methods
Chemical Biology
Drug design
Molecular Modelling

Photograph of Colin Fishwick

Research interests

Computer-aided design and subsequent synthesis of drug-like molecules directed against important therapeutic targets including antibacterial, antimalarial, antithrombotic, anti-Alzheimer's agents and anti-cancer agents. Development of new synthetic methods based around 1,3-dipolar, and hetero Diels-Alder cycloadditions.
Use of synthetic 'probe' molecules in the study of biological structure and function.

Useful links

Fishwick group pages   


Thorp-Greenwood FL, Brennan AD, Oldknow S, Henkelis JJ, Simmons KJ, Fishwick CWG, Hardie MJ Tris-N-alkylpyridinium-functionalised cyclotriguaiacylene hosts as axles in branched [4]pseudorotaxane formation Supramolecular Chemistry 29 430-440, 2017
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Dilly SJ, Clark AJ, Marsh A, Mitchell DA, Cain R, Fishwick CWG, Taylor PC A chemical genomics approach to drug reprofiling in oncology: Antipsychotic drug risperidone as a potential adenocarcinoma treatment Cancer Letters 393 16-21, 2017
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Cahill ST, Cain R, Wang DY, Lohans CT, Wareham DW, Oswin HP, Mohammed J, Spencer J, Fishwick CWG, McDonough MA, Schofield CJ, Brem J Cyclic Boronates Inhibit All Classes ofβ-Lactamase Antimicrobial Agents and Chemotherapy 61 -, 2017
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Gordon JA, Fishwick CWG, McPhillie MJ New Opportunities in the Structure-based Design of Anti-Protozoan Agents Current topics in medicinal chemistry 17 79-90, 2017
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Caseley EA, Muench SP, Fishwick CW, Jiang LH Structure-based identification and characterisation of structurally novel human P2X7 receptor antagonists Biochemical Pharmacology 116 130-139, 2016
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Brem J, Cain R, Cahill S, McDonough MA, Clifton IJ, Jimenez-Castellanos J-C, Avison MB, Spencer J, Fishwick CWG, Schofield CJ Structural basis of metallo-beta-lactamase, serine-beta-lactamase and penicillin-binding protein inhibition by cyclic boronates Nature Communications 7 -, 2016

McPhillie M, Zhou Y, El Bissati K, Dubey J, Lorenzi H, Capper M, Lukens AK, Hickman M, Muench S, Verma SK, Weber CR, Wheeler K, Gordon J, Sanders J, Moulton H, Wang K, Kim TK, He Y, Santos T, Woods S, Lee P, Donkin D, Kim E, Fraczek L, Lykins J, Esaa F, Alibana-Clouser F, Dovgin S, Weiss L, Brasseur G, Wirth D, Kent M, Hood L, Meunieur B, Roberts CW, Hasnain SS, Antonyuk SV, Fishwick C, McLeod R New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections Scientific Reports 6 -, 2016
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Dondas HA, Hempshall A, Narramore S, Kilner C, Fishwick CWG, Grigg R γ-Carboline AC190 analogues via palladium catalysed allene insertion stereo and regioselective 3- and 5- component cascades Tetrahedron 72 1316-1329, 2016
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Dondas HA, Hempshall A, Narramore S, Kilner C, Fishwick CWG, Grigg R gamma-Carboline AC190 analogues via palladium catalysed allene insertion stereo and regioselective 3-and 5-component cascades TETRAHEDRON 72 1316-1329, 2016

Naylor J, Minard A, Gaunt HJ, Amer MS, Wilson LA, Migliore M, Cheung SY, Rubaiy HN, Blythe NM, Musialowski KE, Ludlow MJ, Evans WD, Green BL, Yang H, You Y, Li J, Fishwick CWG, Muraki K, Beech DJ, Bon RS Natural and synthetic flavonoid modulation of TRPC5 channels British Journal of Pharmacology 173 562-574, 2016
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Grigg R, Elboray EE, Akkarasamiyo S, Chuanopparat N, Dondas HA, Abbas-Temirek HH, Fishwick CWG, Aly MF, Kongkathip B, Kongkathip N A facile palladium catalysed 3-component cascade route to functionalised isoquinolinones and isoquinolines CHEMICAL COMMUNICATIONS 52 164-166, 2016

Shaw J, Harris M, Fishwick CWG Identification of a lead like inhibitor of the hepatitis C virus non-structural NS2 autoprotease Antiviral Research 124 54-60, 2015
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Lolli M, Narramore S, Fishwick CWG, Pors K Refining the chemical toolbox to be fit for educational and practical purpose for drug discovery in the 21st Century Drug Discovery Today 20 1018-1026, 2015
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Avery CA, Pease RJ, Smith K, Boothby M, Buckley HM, Grant PJ, Fishwick CWG (±) cis-bisamido epoxides: A novel series of potent FXIII-A inhibitors European Journal of Medicinal Chemistry 98 49-53, 2015
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Latham AM, Kankanala J, Fishwick CW, Ponnambalam S Identification of Receptor Tyrosine Kinase Inhibitors Using Cell Surface Biotinylation and Affinity Isolation. Methods in molecular biology (Clifton, N.J.) 1332 121-131, 2015
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Kime L, Vincent HA, Gendoo DMA, Jourdan SS, Fishwick CWG, Callaghan AJ, McDowall KJ The first small-molecule inhibitors of members of the ribonuclease E family Scientific Reports 5 8028-, 2015
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Shaw J, Fishwick CWG, Harris M Epoxide based inhibitors of the hepatitis C virus non-structural 2 autoprotease Antiviral Research 117 20-26, 2015
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McPhillie MJ, Cain RM, Narramore S, Fishwick CWG, Simmons KJ Computational methods to identify new antibacterial targets Chemical Biology and Drug Design 85 22-29, 2015
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Latham AM, Kankanala J, Fearnley GW, Gage MC, Kearney MT, Homer-Vanniasinkam S, Wheatcroft SB, Fishwick CWG, Ponnambalam S In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis PLoS ONE 9 -, 2014
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Yule IA, Czaplewski LG, Pommier S, Davies DT, Narramore SK, Fishwick CWG Pyridine-3-carboxamide-6-yl-ureas as novel inhibitors of bacterial DNA gyrase: Structure based design, synthesis, SAR and antimicrobial activity European Journal of Medicinal Chemistry 86 31-38, 2014
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Simmons KJ, Jackson SM, Brueckner F, Patching SG, Beckstein O, Ivanova E, Geng T, Weyand S, Drew D, Lanigan J, Sharples DJ, Sansom MS, Iwata S, Fishwick CW, Johnson AP, Cameron AD, Henderson PJ Molecular mechanism of ligand recognition by membrane transport protein, Mhp1 The EMBO Journal 33 1831-1844, 2014
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Cain R, Narramore S, McPhillie M, Simmons K, Fishwick CWG Applications of structure-based design to antibacterial drug discovery BIOORGANIC CHEMISTRY 55 69-76, 2014

Lolicato M, Bucchi A, Arrigoni C, Zucca S, Nardini M, Schroeder I, Simmons K, Aquila M, DiFrancesco D, Bolognesi M, Schwede F, Kashin D, Fishwick CW, Johnson AP, Thiel G, Moroni A Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness Nature Chemical Biology 10 457-462, 2014
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Cookson NJ, Henkelis JJ, Ansell RJ, Fishwick CW, Hardie MJ, Fisher J Encapsulation of sodium alkyl sulfates by the cyclotriveratrylene-based, [Pd(6)L(8)](12+) stella octangula cage. Dalton Trans 43 5657-5661, 2014
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Fisher M, Basak R, Kalverda AP, Fishwick CW, Turnbull WB, Nelson A Discovery of novel FabF ligands inspired by platensimycin by integrating structure-based design with diversity-oriented synthetic accessibility. Org Biomol Chem 12 486-494, 2014
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Cunningham F, McPhillie MJ, Johnson AP, Fishwick CW An in silico structure-based approach to anti-infective drug discovery. Parasitology 141 17-27, 2014
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Lloyd AJ, Potter NJ, Fishwick CWG, Roper DI, Dowson CG Adenosine Tetraphosphoadenosine Drives a Continuous ATP-Release Assay for Aminoacyl-tRNA Synthetases and Other Adenylate-Forming Enzymes ACS Chemical Biology 8 2157-2163, 2013
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van Berkel SS, Brem J, Rydzik AM, Salimraj R, Cain R, Verma A, Owens RJ, Fishwick CWG, Spencer J, Schofield CJ Assay platform for clinically relevant metallo-beta-lactamases Journal of Medicinal Chemistry 56 6945-6953, 2013
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Smith KA, Pease RJ, Avery CA, Brown JM, Adamson PJ, Cooke EJ, Neergaard-Petersen S, Cordell PA, Ariëns RA, Fishwick CW, Philippou H, Grant PJ The activation peptide cleft exposed by thrombin cleavage of FXIII-A(2) contains a recognition site for the fibrinogenα chain. Blood 121 2117-2126, 2013
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Simmons KJ, Gotfryd K, Billesbølle CB, Loland CJ, Gether U, Fishwick CW, Johnson AP A virtual high-throughput screening approach to the discovery of novel inhibitors of the bacterial leucine transporter, LeuT. Mol Membr Biol 30 184-194, 2013
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Fishwick CWG, Chadwick J, Kellet K, Casas_Arce E, Hooper N, Johnson AP, Mok Y Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design Journal of Medicinal Chemistry 56 1843-1852, 2013
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Yule IA, Fishwick CWG A simple, one-pot synthesis of N-Alkyl and N-aryl thieno[2,3-d] pyrimidinones from thiophene-and benzothiophene-2-yl-ureas Synthetic Communications 43 337-344, 2013
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Wacker SJ, Jurkowski W, Simmons KJ, Fishwick CWG, Johnson AP, Madge D, Lindahl E, Rolland JF, deGroot BL Identification of Selective Inhibitors of the Potassium Channel Kv1.1-1.2(3) by High-Throughput Virtual Screening and Automated Patch Clamp ChemMedChem 7 1775-1783, 2012
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Bedingfield PT, Cowen D, Acklam P, Cunningham F, Parsons MR, McConkey GA, Fishwick CW, Johnson AP Factors influencing the specificity of inhibitor binding to the human and malaria parasite dihydroorotate dehydrogenases. J Med Chem 55 5841-5850, 2012
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Kankanala J, Latham AM, Johnson AP, Homer-Vanniasinkam S, Fishwick CW, Ponnambalam S A combinatorial in silico and cellular approach to identify a new class of compounds that target VEGFR2 receptor tyrosine kinase activity and angiogenesis. Br J Pharmacol 166 737-748, 2012
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Wetherill LF, Holmes KK, Verow M, Müller M, Howell G, Harris M, Fishwick C, Stonehouse N, Foster R, Blair GE, Griffin S, Macdonald A High-risk human papillomavirus E5 oncoprotein displays channel-forming activity sensitive to small-molecule inhibitors Journal of Virology 86 5341-5351, 2012
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Patching SG, Jackson S, Simmons KJ, Ma P, Baldwin SA, Johnson P, Fishwick CWG, Henderson PJF Isotope chemistry for investigating ligand binding and transport by Mhp1 and its homologues JOURNAL OF LABELLED COMPOUNDS&RADIOPHARMACEUTICALS 55 , 2012

Latham AM, Bruns AF, Kankanala J, Johnson AP, Fishwick CW, Homer-Vanniasinkam S, Ponnambalam S Indolinones and anilinophthalazines differentially target VEGF-A- and basic fibroblast growth factor-mediated responses in primary human endothelial cells. Br J Pharmacol 165 245-259, 2012
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Majeed Y, Tumova S, Green BL, Seymour VA, Woods DM, Agarwal AK, Naylor J, Jiang S, Picton HM, Porter KE, O'Regan DJ, Muraki K, Fishwick CW, Beech DJ Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone. Cell Calcium 51 1-11, 2012
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McPhillie MJ, Trowbridge R, Mariner KR, O'Neill AJ, Johnson AP, Chopra I, Fishwick CWG Structure-Based Ligand Design of Novel Bacterial RNA Polymerase Inhibitors ACS MED CHEM LETT 2 729-734, 2011

Elboray EE, Grigg R, Fishwick CWG, Kilner C, Sarker MAB, Aly MF, Abbas-Temirek HH X=Y-ZH compounds as potential 1,3-dipoles. Part 65: atom economic cascade synthesis of highly functionalized pyrimidinylpyrrolidines TETRAHEDRON 67 5700-5710, 2011

Smith EL, John S, Abdinejad M, Kankanala J, Fishwick CWG, Philippou E Elucidating novel urokinase-type plasminogen activator inhibitors JOURNAL OF THROMBOSIS AND HAEMOSTASIS 9 819-819, 2011

Mariner K, McPhillie M, Trowbridge R, Smith C, O'Neill AJ, Fishwick CW, Chopra I Activity of and development of resistance to corallopyronin A, an inhibitor of RNA polymerase. Antimicrob Agents Chemother 55 2413-2416, 2011
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Majeed Y, Amer MS, Agarwal AK, McKeown L, Porter KE, O'Regan DJ, Naylor J, Fishwick CW, Muraki K, Beech DJ Stereo-selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids. Br J Pharmacol 162 1509-1520, 2011
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Woon ECY, Zervosen A, Sauvage E, Simmons KJ, Zivec M, Inglis SR, Fishwick CWG, Gobec S, Charlier P, Luxen A, Schofield CJ Structure Guided Development of Potent Reversibly Binding Penicillin Binding Protein Inhibitors ACS MED CHEM LETT 2 219-223, 2011

Mariner KR, Trowbridge R, Agarwal AK, Miller K, O'Neill AJ, Fishwick CW, Chopra I Furanyl-rhodanines are unattractive drug candidates for development as inhibitors of bacterial RNA polymerase. Antimicrob Agents Chemother 54 4506-4509, 2010
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Majeed Y, Agarwal AK, Naylor J, Seymour VA, Jiang S, Muraki K, Fishwick CW, Beech DJ Cis-isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels. Br J Pharmacol 161 430-441, 2010
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Simmons KJ, Chopra I, Fishwick CWG Structure-based discovery of antibacterial drugs NAT REV MICROBIOL 8 501-510, 2010

Cowen D, Bedingfield P, McConkey GA, Fishwick CWG, Johnson AP A study of the effects of substituents on the selectivity of the binding of N-arylaminomethylene malonate inhibitors to DHODH BIOORG MED CHEM LETT 20 1284-1287, 2010

Miller K, Dunsmore CJ, Leeds JA, Patching SG, Sachdeeva M, Blake KL, Stubbings WJ, Simmons KJ, Henderson PJF, De Los Angeles J, Fishwick CWG, Chopra I Benzothioxalone derivatives as novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferases (MurA and MurZ) Journal of Antimicrobial Chemotherapy 65 2566-2573, 2010

Agarwal AK, Fishwick CWG Structure-based design of anti-infectives ANN NY ACAD SCI 1213 20-45, 2010

Mok NY, Chadwick J, Kellett KAB, Hooper NM, Johnson AP, Fishwick CWG Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening BIOORG MED CHEM LETT 19 6770-6774, 2009

StGelais C, Foster TL, Verow M, Atkins E, Fishwick CWG, Rowlands D, Harris M, Griffin S Determinants of Hepatitis C Virus p7 Ion Channel Function and Drug Sensitivity Identified In Vitro J VIROL 83 7970-7981, 2009

Vickers AA, Potter NJ, Fishwick CWG, Chopra I, O'Neill AJ Analysis of mutational resistance to trimethoprim in Staphylococcus aureus by genetic and structural modelling techniques J ANTIMICROB CHEMOTH 63 1112-1117, 2009

Davies M, Heikkila T, McConkey GA, Fishwick CWG, Parsons MR, Johnson AP Structure-Based Design, Synthesis, and Characterization of Inhibitors of Human and Plasmodium falciparum Dihydroorotate Dehydrogenases J MED CHEM 52 2683-2693, 2009

Blake KL, O'Neill AJ, Mengin-Lecreulx D, Henderson PJF, Bostock JM, Dunsmore CJ, Simmons KJ, Fishwick CWG, Leeds JA, Chopra I The nature of Staphylococcus aureus MurA and MurZ and approaches for detection of peptidoglycan biosynthesis inhibitors MOL MICROBIOL 72 335-343, 2009

Johnson AP, Fishwick CWG, McConkey GA, Heikkila T, Davies M, Cowan D, Agarwal A Computational approaches to antibacterial and antimalarial hit finding ABSTR PAP AM CHEM S 237 , 2009

Brozic P, Cesar J, Kovac A, Davies M, Johnson AP, Fishwick CWG, Rizner TL, Gobec S Derivatives of pyrimidine, phthalimide and anthranilic acid as inhibitors of human hydroxysteroid dehydrogenase AKR1C1 CHEMICO-BIOLOGICAL INTERACTIONS 178 , 2009

Sova M, Cadez G, Turk S, Majce V, Polanc S, Batson S, Lloyd AJ, Roper DI, Fishwick CWG, Gobec S Design and synthesis of new hydroxyethylamines as inhibitors of D-alanyl-D-lactate ligase (VanA) and D-alanyl-D-alanine ligase (DdlB) BIOORG MED CHEM LETT 19 1376-1379, 2009

Agarwal AK, Johnson AP, Fishwick CWG Synthesis of de novo designed small-molecule inhibitors of bacterial RNA polymerase (vol 64, pg 10049, 2008) TETRAHEDRON 65 1077-1077, 2009

Agarwal AK, Johnson AP, Fishwick CWG Synthesis of de novo designed small-molecule inhibitors of bacterial RNA polymerase TETRAHEDRON 64 10049-10054, 2008

Uppal S, Diggle CP, Carr IM, Fishwick CWG, Ahmed M, Ibrahim GH, Helliwell PS, Latos-Bielenska A, Phillips SEV, Markham AF, Bennett CP, Bonthron DT Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy (vol 40, pg 789, 2008) NAT GENET 40 927-927, 2008

Uppal S, Diggle CP, Carr IM, Fishwick CWG, Ahmed M, Ibrahim GH, Helliwell PS, Latos-Bielenska A, Phillips SEV, Markham AF, Bennett CP, Bonthron DT Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy NAT GENET 40 789-793, 2008

Fishwick CWG, Uppal S, Diggle CP, Carr IM, Ahmed M, Ibrahim GH, Helliwell PS, Latos-Bielenska A, Phillips SEV, Markham AF, Bennett CP, Bonthron DT Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy Nature Genetics 40 789-793, 2008
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Miller K, Dunsmore CJ, Fishwick CWG, Chopra I Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center ANTIMICROB AGENTS CH 52 1737-1742, 2008

Dunsmore C, Miller K, Blake KL, Patching SG, Henderson PJF, Garnett JA, Stubbings WJ, Phillips SEV, Palestrant DJ, De Los Angeles J, Leeds JA, Chopra I, Fishwick CWG 2-Aminotetralones: Novel inhibitors of MurA and MurZ Bioorganic and Medicinal Chemistry Letters 18 1730-1734, 2008
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Grigg R, Sarkar MRA, Thayaparan A, Sridharan V, Fishwick CWG Pd(0) catalyzed three-five-component C-2-arylallylation of active methylene heterocycles: pyrazolones, oxazolones, isoxazolones and N,N '-dimethylbarbituric acid TETRAHEDRON 63 7213-7228, 2007

Heikkila T, Ramsey C, Davies M, Galtier C, Stead AMW, Johnson AP, Fishwick CWG, Boa AN, McConkey GA Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase J MED CHEM 50 186-191, 2007

Gill JH, Fishwick CWG, Androutsopoulos V, Mohanarajah A, Khamnaen T, Patterson LH, Shnyder SD, Loadman PM, Grigg R Preclinical evaluation of a rationally designed novel class of non-hydroxamate Histone Deacetylase inhibitors (HDACi) EJC SUPPL 4 98-98, 2006

Agarwal AK, Hurdle JG, AlOmar AI, Chopra I, Johnson AP, Fishwick CWG MEDI 326-De Novo design and synthesis of novel RNA polymerase inhibitors as potential anti-tuberculosis agents ABSTR PAP AM CHEM S 232 -, 2006

Davies RPW, Aggeli A, Beevers AJ, Boden N, Carrick LM, Fishwick CWG, McLeish TCB, Nyrkova I, Semenov AN Self-assembling beta-sheet tape forming peptides SUPRAMOL CHEM 18 435-443, 2006

O'Neill AJ, Huovinen T, Fishwick CWG, Chopra I Molecular Genetic and Structural Modeling Studies of Staphylococcus aureus RNA Polymerase and the Fitness of Rifampin Resistance Genotypes in Relation to Clinical Prevalence Antimicrobial Agents&Chemotherapy 50 298-309, 2006
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Grigg RE, McCaffrey S, Sridharan V, Fishwick CWG, Kilner CA, Korn S, Bailey K, Blacker J Enantioselective Synthesis of Non-Proteinogenic 2-Arylallylα-Amino Acids via Pd/In Catalytic Cascades. Tetrahedron 62 12159-12171, 2006

Heikkila T, Thirumalairajan S, Davies M, Parsons MR, McConkey AG, Fishwick CWG, Johnson AP The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase BIOORG MED CHEM LETT 16 88-92, 2006

Ali MA, Bhogal N, Findlay JB, Fishwick CW The first de novo-designed antagonists of the human NK(2) receptor. J Med Chem 48 5655-5658, 2005
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Sanderson JM, Findlay JBC, Fishwick CWG Preparation of novel 3H-trifluoromethyldiazirine-based photoactivatable potassium channel antagonists Tetrahedron 61 11244-11252, 2005

Ali MA, Bhogal N, Findlay JBC, Fishwick CWG The First de Novo-Designed Antagonists of the Human NK2receptor Journal of Medicinal Chemistry 48 5655-5658, 2005
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Besong GE, Bostock JM, Stubbings WJ, Chopra I, Roper DI, Lloyd AJ, Fishwick CWG, Johnson AP A De Novo Designed Inhibitor of D-Ala-D-Ala Ligase from E. coli Angewandte Chemie - International Edition 44 6403-6406, 2005

Whitehouse C, Fang JY, Aggeli A, Bell M, Brydson RMD, Fishwick CWG, Henderson JR, Knobler CM, Owens RW, Thomson NH, Smith DA, Boden N Adsorption and Self-Assembly of Peptides on Mica Substrates Angewandte Chemie - International Edition 44 1965-1968, 2005

Fishwick CWG, Mitchell G, Pang PFW Ozonolytic cleavage of 3-oxidopyrilium betaine-derived cycloadducts: Simple and efficient access to stereodefined tetrahydrofurans SYNLETT 285-286, 2005

Besong GE, Bostock JM, Stubbings W, Chopra I, Roper DI, Lloyd AJ, Fishwick CWG, Johnson AP A de Novo designed inhibitor of D-Ala-D-Ala ligase from E-coli ANGEW CHEM INT EDIT 44 6403-6406, 2005

Whitehouse C, Fang JY, Aggeli A, Bell M, Brydson R, Fishwick CWG, Henderson JR, Knobler CM, Owens RW, Thomson NH, Smith DA, Boden N Adsorption and self-assembly of peptides on mica substrates ANGEW CHEM INT EDIT 44 1965-1968, 2005

Dondas HA, Fishwick CWG, Gai XJ, Grigg R, Kilner C, Dumrongchai N, Kongkathip B, Kongkathip N, Polysuk C, Sridharan V Stereoselective palladium-catalyzed four-component cascade synthesis of pyrrolidinyl-, pyrazolidinyl-, and isoxazolidinyl isoquinolines ANGEW CHEM INT EDIT 44 7570-7574, 2005

Dondas HA, Fishwick CWG, Grigg RE, Kilner CA 1, 3-Dipolar cycloaddition of stabilised and non-stabilised azomethine ylides derived from uracil polyoxin C (UPoC): access to nikkomycin anologues Tetrahedron 60 3473-3485, 2004

Dondas HA, Fishwick CWG, Grigg RE, Thornton-Pett M X=Y–ZH system as potential 1,3-dipoles. Part 59: Cascade 1,3-azaprotio cyclotransfer–1,3-dipolar cycloaddition (1,3-APT–1,3-DC) reactions of benzobicyclo[3.3.1]non-5-en-9-one oxime Tetrahedron 59 9997-10007, 2003

Cleghorn L, Cooper IR, Fishwick CWG, Grigg RE, MacLachlan WS, Rasparini M, Sridharan V Three-component bimetallic (Pd/In) mediated cascade allylation of C=X functionality - Part 1. Scope and Class 1 examples with aldehydes and ketones Journal of Organometallic Chemistry 687 483-493, 2003

Fishwick CWG, Beevers AJ, Carrick LM, Whitehouse CD, Aggeli A, Boden N Structures of Helicalβ-Tapes and Twisted Ribbons: The Role of Side-Chain Interactions on Twist and Bend Behavior Nano Letters 3 1475-1479, 2003

Aggeli A, Bell M, Carrick LM, Fishwick CWG, Harding R, Mawer PJ, Radford SE, Strong AE, Boden N pH as a trigger of peptide beta-sheet self-assembly and reversible switching between nematic and isotropic phases J AM CHEM SOC 125 9619-9628, 2003

Fishwick CWG, Grigg R, Sridharan V, Virica J Sequential azomethine imine cycloaddition-palladium catalysed cyclisation processes TETRAHEDRON 59 4451-4468, 2003

Horton JR, Bostock JM, Chopra I, Hesse L, Phillips SEV, Adams DJ, Johnson AP, Fishwick CWG Macrocyclic inhibitors of the bacterial cell wall biosynthesis enzyme mur D Bioorganic and Medicinal Chemistry Letters 13 1557-1560, 2003

Fishwick CWG, Grigg RE, Dondas HA, Kilner CA X=Y-ZH system as potential 1,3-dipoles. Part 59: Cascade 1,3-azaprotio cyclotransfer-1,3-dipolar cycloaddition (1,3-APT-1,3-DC) reactions of benzobicyclo[3.3.1]non-5-en-9-one Tetrahedron 59 9997-10007, 2003

Ali M, Bhogal N, Fishwick CWG, Findlay JBC Spatial requirements of the antagonist binding site of the NK2receptor Bioorganic and Medicinal Chemistry Letters 11 819-822, 2001

Brown GA, Martel SR, Wisedale R, Charmant JPH, Hales NJ, Fishwick CWG, Gallagher T The azomethine ylide strategy for beta-lactam synthesis. An evaluation of alternative pathways for azomethine ylide generation J CHEM SOC PERK T 1 1281-1289, 2001

Brown GA, Martel SR, Planchenault D, Turmes E, Wisedale R, Hales NJ, Fishwick CWG, Gallagher T The Azomethine Ylide Stategy for Beta Lactam Synthesis. An Exploration of Alternative Pathways. Royal Society of Chemistry. Journal: Perkin Transactions 1 1281-1289, 2001

Brown D, Brown GA, Martel SR, Planchenault D, Turmes E, Walsh KE, Wisedale R, Hales NJ, Gallagher T, Fishwick CWG The Azomethine Ylide Strategy for Beta Lactam Synthesis. A Mechanistic Evaluation. Perkin 1. 1270-1280, 2001

Brown D, Brown GA, Martel SR, Planchenault D, Turmes E, Walsh KE, Wisedale R, Hales NJ, Fishwick CWG, Gallagher T The azomethine ylide strategy for beta-lactam synthesis. A comprehensive mechanistic evaluation J CHEM SOC PERK T 1 1270-1280, 2001

O'Neill A, Oliva B, Storey CC, Hoyle A, Fishwick CWG, Chopra I RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus International Journal of Antimicrobial Agents and Chemotherapy 44 3163-3166, 2000

Fishwick CWG, Findlay JBC, Sanderson JM, Singh P The synthesis and reactivity of optically pure amino acids bearing side-chain thioamides. Royal Society of Chemistry. Journal: Perkin Transactions 1 19 3227-3231, 2000

Fishwick CWG, Reed JE, Bell AS Facile palladium catalysed functionalisation of 1,2-Isothiazoline-3-ones and the highly diastereoselective diels-alder reactions of 4-vinyl-1,2-isothiazoline-3-one-1-oxides. Tetrahedron 55 12313-12330, 1999

Fishwick CWG, Reed JE, Bell AS Generation and cycloadditions of 2-(N-acylamino)-1-thia-1,3-dienes part III; Control of diastereoselectivity using homochiral auxilaries. Tetrahedron 54 3219-3234, 1998

Fishwick CWG, Singh P, Hurrell CR, Findlay JBC Two novel amino acid derivatives containing side-chain thioamides for the synthesis of photoactivatable peptides. Bioorganic and Medicinal Chemistry Letters 7 715-718, 1997

Fishwick CWG, Foster RJ, Carr RE A short dipolar cycloaddition approach toγ-lactam alkaloids fromcynometra hankei Tetrahedron Letters 37 3915-3918, 1996

Grigg RE, Dondas HA, Fishwick CWG, Thornton-Pett MA X=Y-ZH Systems as Potential 1,3-Dipoles. Part 60. Cycloaddition of Azomethine Ylides Derived from Uracil Polyoxin C (UPoC): Acess to Nikkomycin Analogues. Tetrahedron -,

Baxter EW, Robinson JI, Tomlinson DC, Foster RJ, Owen RL, Win SJ, Nettleship JE, Tiede C, Kankanala J, Owens RJ, Fishwick CWG, McPherson MJ, Morgan AW Novel Agents for Blocking the Interaction of Immune complexes eith the activatory FcgRIIIa receptor,
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