School of Chemistry

Robin Bon

Senior Translational Research Fellow
Research section: Organic Chemistry

Contact details

Keywords

Synthetic Organic Chemistry
Medicinal Chemistry
Chemical Biology
Chemical Genetics
Biology Oriented Synthesis

Research interests

Our group works on the synthesis of natural product-inspired compound libraries, the design, synthesis and evaluation of small molecule probes of protein function and the development of tools for biochemical assays and in vivo imaging. Most projects are highly interdisciplinary and rely on collaborations between chemists, biologists, engineers and medics, for example through the Multidisciplinary Cardiovascular Research Centre (MCRC) and The Astbury Centre for Structural Molecular Biology.

Useful links

Astbury Centre for Structural Molecular Biology    
Biomedical Health Research Centre   
Multidisciplinary Cardiovascular Research Centre   

Selected publications

Bon, R.S.; Waldmann, H. Accounts of Chemical Research 2010, 8, 1103–1114: 'Bioactivity-Guided Navigation of Chemical Space'

Tan, K.-T.; Guiu-Rozas, E.; Bon, R.S.; Guo, Z.; Delon, C.; Wetzel, S.; Arndt, S.; Alexandov, K.; Waldmann, H.; Goody, R.S.; Wu, Y.-W.; Blankenfeldt, W. Journal of Medicinal Chemistry 2009, 52, 8025–8037: 'Design, Synthesis, and Characterization of Peptide-Based Rab Geranylgeranyl Transferase Inhibitors'

Guo, Z.; Wu, Y.-W.; Tan, K.-T.; Bon, R.S.; Guiu-Rozas, E.; Delon, C.; Nguyen, U.T.; Wetzel, S.; Arndt, S.; Goody, R.S.; Blankenfeldt, W.; Alexandrov, K.; Waldmann, H. Angewandte Chemie International Edition 2008, 47, 20, 3747–3750: 'Development of Selective RabGGTase Inhibitors and Crystal Structure of a RabGGTase-Inhibitor Complex'

Bon, R.S.; Sprenkels, N.E.; Koningstein, M.M.; Schmitz, R.F.; de Kanter, F.J.J.; Dömling, A.; Groen, M.B.; Orru, R.V.A. Organic and Biomolecular Chemistry 2008, 6, 1, 130–137: 'Efficient C2 Functionalisation of 2H-2-imidazolines'