School of Chemistry

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Robin Bon

Senior Translational Research Fellow
Member of the Chemical Biology and Medicinal Chemistry group

Contact details

Room: G18b
Tel: +44 (0)113 3433196


Synthetic Organic Chemistry
Medicinal Chemistry
Chemical Biology
Chemical Genetics
Biology Oriented Synthesis

Photograph of Robin Bon

Research interests

Our group works on the synthesis of natural product-inspired compound libraries, the design, synthesis and evaluation of small molecule probes of protein function and the development of tools for biochemical assays and in vivo imaging. Most projects are highly interdisciplinary and rely on collaborations between chemists, biologists, engineers and medics, for example through the Multidisciplinary Cardiovascular Research Centre (MCRC) and The Astbury Centre for Structural Molecular Biology.

Useful links

Astbury Centre for Structural Molecular Biology    
Biomedical Health Research Centre   
Multidisciplinary Cardiovascular Research Centre   


Tiede C, Bedford R, Heseltine SJ, Smith G, Wijetunga I, Ross R, Alqallaf D, Roberts APE, Balls A, Curd A, Hughes RE, Martin H, Needham SR, Zanetti-Domingues LC, Sadigh Y, Peacock TP, Tang AA, Gibson N, Kyle H, Platt GW, Ingram N, Taylor T, Coletta LP, Manfield I, Knowles M, Bell S, Esteves F, Maqbool A, Prasad RK, Drinkhill M, Bon RS, Patel V, Goodchild SA, Martin-Fernandez M, Owens RJ, Nettleship JE, Webb ME, Harrison M, Lippiat JD, Ponnambalam S, Peckham M, Smith A, Ferrigno PK, Johnson M, McPherson MJ, Tomlinson DC Affimer proteins are versatile and renewable affinity reagents eLife 6 -, 2017
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Rubaiy HN, Ludlow MJ, Henrot M, Gaunt HJ, Miteva K, Cheung SY, Tanahashi Y, Hamzah N, Musialowski KE, Blythe NM, Appleby HL, Bailey MA, McKeown L, Taylor R, Foster R, Waldmann H, Nussbaumer P, Christmann M, Bon RS, Muraki K, Beech DJ Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels Journal of Biological Chemistry 292 8158-8173, 2017
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Rubaiy HN, Ludlow MJ, Bon RS, Beech DJ Pico145 - powerful new tool for TRPC1/4/5 channels Channels 1-3, 2017

Koutsoumpeli E, Tiede C, Murray J, Tang A, Bon RS, Tomlinson DC, Johnson S Antibody Mimetics for the Detection of Small Organic Compounds Using a Quartz Crystal Microbalance Analytical Chemistry 89 3051-3058, 2017
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Hauser JR, Beard HA, Bayana ME, Jolley KE, Warriner SL, Bon RS Economical and scalable synthesis of 6-amino-2-cyanobenzothiazole Beilstein Journal of Organic Chemistry 12 2019-2025, 2016
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Bon RS Identification of the Molecular Target of an Inducer of Human Glioblastoma Self-Destruction, 2016
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Naylor J, Minard A, Gaunt HJ, Amer MS, Wilson LA, Migliore M, Cheung SY, Rubaiy HN, Blythe NM, Musialowski KE, Ludlow MJ, Evans WD, Green BL, Yang H, You Y, Li J, Fishwick CWG, Muraki K, Beech DJ, Bon RS Natural and synthetic flavonoid modulation of TRPC5 channels British Journal of Pharmacology 173 562-574, 2016
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Koutsoumpeli E, Murray J, Langford D, Bon RS, Johnson S Probing molecular interactions with methylene blue derivatized self-assembled monolayers Sensing and Bio-Sensing Research 6 1-6, 2015
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Fisher MJ, Williamson DJ, Burslem GM, Plante JP, Manfield IW, Tiede C, Ault JR, Stockley PG, Plein S, Maqbool A, Tomlinson DC, Foster R, Warriner SL, Bon RS Trivalent Gd-DOTA reagents for modification of proteins RSC Advances 5 96194-96200, 2015
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Murray J, Nowak D, Pukenas L, Azhar R, Guillorit M, Wälti C, Critchley K, Johnson S, Bon RS Solid phase synthesis of functionalised SAM-forming alkanethiol- oligoethyleneglycols Journal of Materials Chemistry B 2 3741-3744, 2014
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Bon RS, Beech DJ In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels -- mirage or pot of gold? Br J Pharmacol 170 459-474, 2013
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Amer MS, McKeown L, Tumova S, Liu R, Seymour VA, Wilson LA, Naylor J, Greenhalgh K, Hou B, Majeed Y, Turner P, Sedo A, O'Regan DJ, Li J, Bon RS, Porter KE, Beech DJ Inhibition of endothelial cell Ca²⁺ entry and transient receptor potential channels by Sigma-1 receptor ligands British Journal of Pharmacology 168 1445-1455, 2013
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Stigter EA, Guo Z, Bon RS, Wu Y-W, Choidas A, Wolf A, Menninger S, Waldmann H, Blankenfeldt W, Goody RS Development of selective, potent RabGGTase inhibitors. J Med Chem 55 8330-8340, 2012
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Deraeve C, Guo Z, Bon RS, Blankenfeldt W, DiLucrezia R, Wolf A, Menninger S, Stigter EA, Wetzel S, Choidas A, Alexandrov K, Waldmann H, Goody RS, Wu Y-W Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase. J Am Chem Soc 134 7384-7391, 2012
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Samatov TR, Wolf A, Odenwälder P, Bessonov S, Deraeve C, Bon RS, Waldmann H, Lührmann R Psoromic acid derivatives: a new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay. Chembiochem 13 640-644, 2012

Mooijman M, Bon RS, Sprenkels NE, van Oosterhout HN, de Kanter FJJ, Groen MB, Ruijter E, Orru RVA Synthesis of Imidazolidine-2-(thi)ones via C2-Selective Oxidation and Thionation of 2-Imidazolinium Halides SYNLETT 23 80-84, 2012

Wetzel S, Bon RS, Kumar K, Waldmann H Biology-oriented synthesis. Angew Chem Int Ed Engl 50 10800-10826, 2011
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Hedberg C, Dekker FJ, Rusch M, Renner S, Wetzel S, Vartak N, Gerding-Reimers C, Bon RS, Bastiaens PIH, Waldmann H Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design. Angew Chem Int Ed Engl 50 9832-9837, 2011
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Wagner BK, Gilbert TJ, Hanai J-I, Imamura S, Bodycombe NE, Bon RS, Waldmann H, Clemons PA, Sukhatme VP, Mootha VK A small-molecule screening strategy to identify suppressors of statin myopathy. ACS Chem Biol 6 900-904, 2011
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Bon RS, Guo Z, Stigter EA, Wetzel S, Menninger S, Wolf A, Choidas A, Alexandrov K, Blankenfeldt W, Goody RS, Waldmann H Structure-guided development of selective RabGGTase inhibitors. Angew Chem Int Ed Engl 50 4957-4961, 2011

Bon RS, Waldmann H Bioactivity-guided navigation of chemical space. Acc Chem Res 43 1103-1114, 2010
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Tan K-T, Guiu-Rozas E, Bon RS, Guo Z, Delon C, Wetzel S, Arndt S, Alexandrov K, Waldmann H, Goody RS, Wu Y-W, Blankenfeldt W Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors. J Med Chem 52 8025-8037, 2009
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Nguyen UTT, Guo Z, Delon C, Wu Y, Deraeve C, Fränzel B, Bon RS, Blankenfeldt W, Goody RS, Waldmann H, Wolters D, Alexandrov K Analysis of the eukaryotic prenylome by isoprenoid affinity tagging. Nat Chem Biol 5 227-235, 2009
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Bon RS, Sprenkels NE, Koningstein MM, Schmitz RF, de Kanter FJJ, Dömling A, Groen MB, Orru RVA Efficient C2 functionalisation of 2H-2-imidazolines. Org Biomol Chem 6 130-137, 2008
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Guo Z, Wu Y-W, Tan K-T, Bon RS, Guiu-Rozas E, Delon C, Nguyen TU, Wetzel S, Arndt S, Goody RS, Blankenfeldt W, Alexandrov K, Waldmann H Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex. Angew Chem Int Ed Engl 47 3747-3750, 2008

Bon RS, de Kanter FJJ, Lutz M, Spek AL, Jahnke MC, Hahn FE, Groen MB, Orru RVA Multicomponent synthesis of N-heterocyclic carbene complexes ORGANOMETALLICS 26 3639-3650, 2007

Paravidino M, Bon RS, Scheffelaar R, Vugts DJ, Znabet A, Schmitz RF, de Kanter FJJ, Lutz M, Spek AL, Groen MB, Orru RVA Diastereoselective multicomponent synthesis of dihydropyridones with an isocyanide functionality. Org Lett 8 5369-5372, 2006
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Bon RS, van Vliet B, Sprenkels NE, Schmitz RF, de Kanter FJJ, Stevens CV, Swart M, Bickelhaupt FM, Groen MB, Orru RVA Multicomponent synthesis of 2-imidazolines. J Org Chem 70 3542-3553, 2005
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Bon RS, Hong C, Bouma MJ, Schmitz RF, de Kanter FJJ, Lutz M, Spek AL, Orru RVA Novel multicomponent reaction for the combinatorial synthesis of 2-imidazolines. Org Lett 5 3759-3762, 2003
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Veerman JJN, Bon RS, Hue BTB, Girones D, Rutjes FPJT, van Maarseveen JH, Hiemstra H Synthesis of 2,6-bridged piperazine-3-ones by N-acyliminium ion chemistry. J Org Chem 68 4486-4494, 2003
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