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John Blacker

Professor of Process Chemistry
Member of the Process Research and Development group

Contact details

Room: G27
Tel: +44 (0)113 3438239
Email: J.Blacker@leeds.ac.uk

Keywords

Industrial process development
Fine Chemical and pharmaceutical manufacture
Asymmetric catalysis
Chiral synthesis


Photograph of John Blacker

Research interests

Development of chemical and process technologies to improve manufacturing efficiency. Examples include pharmaceutical route design, asymmetric transfer hydrogenation and dehydrogenation, asymmetric cyanation, biocatalysis, continuous flow processing.

Currently involved in setting-up The Institute of Process Research and Development (IPRD).

The Institute of Process Research and Development (IPRD) is a joint initiative by the Schools of Chemistry and Engineering at The University of Leeds. It is being formed to help the fine chemical industry access better chemical and process technology for making products more efficiently and cost effectively with less waste; to provide resources, expertise and advice, particularly in testing speculative but high value ideas on new routes and processes; to support high level training in process development.

The need for IPRD has arisen because financial and regulatory pressures are demanding more efficient processes to produce complex organic chemical products more cheaply, with higher more consistent quality and with less waste. In response to industrys needs, government is calling public institutions to encourage closer collaboration between chemists, engineers, academics and industry.

IPRD will integrate the expertise of chemists, engineers, industrialists and academics. As IPRD develops it is planned to install a kilogramme scale-up lab to be used for test manufacturing and training.

Useful links

Blacker Group Pages   
Institute of Process Research and Development   
Full publication list   

Publications

Husgentobler KG, Rasparini M, Thompson LA, Jolley KE, Blacker AJ, Turner NJ Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, A Key Building Block for the Synthesis of Ticagrelor ORGANIC PROCESS RESEARCH&DEVELOPMENT 21 195-199, 2017
DOI:10.1021/acs.oprd.6b00346

Zhao Y, King G, Kwan MHT, Blacker AJ A Mild and Selective Method for the Catalytic Hydrodeoxygenation of Cyanurate Activated Phenols in Multiphasic Continuous Flow ORGANIC PROCESS RESEARCH&DEVELOPMENT 20 2012-2018, 2016
DOI:10.1021/acs.oprd.6b00314

Lucas SJ, Lord RM, Basri AM, Allison SJ, Phillips RM, Blacker AJ, McGowan PC Increasing anti-cancer activity with longer tether lengths of group 9 Cp∗ complexes Dalton Transactions 45 6812-6815, 2016
DOI:10.1039/c6dt00186f
View abstract

Blacker AJ, Breen JR, Bourne RA, Hone CA The growing impact of continuous flow methods on the twelve principles of green chemistry In RSC Green Chemistry , 2016
DOI:10.1039/9781782625940-00140
View abstract

Stirling MJ, Sweeney G, MacRory K, Blacker AJ, Page MI The kinetics and mechanism of the organo-iridium-catalysed enantioselective reduction of imines ORGANIC&BIOMOLECULAR CHEMISTRY 14 3614-3622, 2016
DOI:10.1039/c6ob00245e

Holmes N, Akien GR, Blacker AJ, Woodward RL, Meadows RE, Bourne RA Self-optimisation of the final stage in the synthesis of EGFR kinase inhibitor AZD9291 using an automated flow reactor REACTION CHEMISTRY&ENGINEERING 1 366-371, 2016
DOI:10.1039/c6re00059b

Sambiagio C, Munday RH, John Blacker A, Marsden SP, McGowan PC Green alternative solvents for the copper-catalysed arylation of phenols and amides RSC Advances 6 70025-70032, 2016
DOI:10.1039/c6ra02265k
View abstract

Stirling MJ, Mwansa JM, Sweeney G, Blacker AJ, Page MI The kinetics and mechanism of the organo-iridium catalysed racemisation of amines ORGANIC&BIOMOLECULAR CHEMISTRY 14 7092-7098, 2016
DOI:10.1039/c6ob00884d

Chapman MR, Kwan MHT, King GE, Kyffin BA, Blacker AJ, Willans CE, Nguyen BN Rapid, metal-free and aqueous synthesis of imidazo[1,2-: A] pyridine under ambient conditions Green Chemistry 18 4623-4627, 2016
DOI:10.1039/c6gc01601d
View abstract

Marce P, Lynch J, Blacker AJ, Williams JMJ Conversion of nitroalkanes into carboxylic acids via iodide catalysis in water CHEMICAL COMMUNICATIONS 52 1013-1016, 2016
DOI:10.1039/c5cc08681g

Marce P, Lynch J, Blacker AJ, Williams JMJ A mild hydration of nitriles catalysed by copper(II) acetate CHEMICAL COMMUNICATIONS 52 1436-1438, 2016
DOI:10.1039/c5cc08714g

Holmes N, Akien GR, Savage RJD, Stanetty C, Baxendale IR, Blacker AJ, Taylor BA, Woodward RL, Meadows RE, Bourne RA Online quantitative mass spectrometry for the rapid adaptive optimisation of automated flow reactors REACTION CHEMISTRY&ENGINEERING 1 96-100, 2016
DOI:10.1039/c5re00083a

Page PCB, Farah MM, Buckley BR, Chan Y, Blacker AJ Preparation of C2-Symmetric Biaryl Bisiminium Salts and Their Use as Organocatalysts for Asymmetric Epoxidation SYNLETT 27 126-130, 2016
DOI:10.1055/s-0035-1560540
View abstract

Blacker AJ, Jolley KE Continuous formation of N-chloro-N,N-dialkylamine solutions in well-mixed meso-scale flow reactors Beilstein Journal of Organic Chemistry 11 2408-2417, 2015
DOI:10.3762/bjoc.11.262
View abstract

Leonard J, Blacker AJ, Marsden SP, Jones MF, Mulholland KR, Newton R A Survey of the Borrowing Hydrogen Approach to the Synthesis of some Pharmaceutically Relevant Intermediates Organic Process Research and Development 19 1400-1410, 2015
DOI:10.1021/acs.oprd.5b00199
View abstract

Sherborne GJ, Chapman MR, Blacker AJ, Bourne RA, Chamberlain TW, Crossley BD, Lucas SJ, Mcgowan PC, Newton MA, Screen TEO, Thompson P, Willans CE, Nguyen BN Activation and deactivation of a robust immobilized Cp*Ir-transfer hydrogenation catalyst: A multielement in situ X-ray absorption spectroscopy study Journal of the American Chemical Society 137 4151-4157, 2015
DOI:10.1021/ja512868a
View abstract

Rodriguez Barzano A, Lord R, Basri AM, Phillips RM, Blacker AJ, McGowan PC Synthesis and anticancer activity evaluation of eta(5)-C-5(CH3)(4)R ruthenium complexes bearing chelating diphosphine ligands Dalton Transactions 44 3265-3270, 2015
DOI:10.1039/c4dt02748e
View abstract

Sambiagio C, Munday RH, Marsden SP, Blacker AJ, McGowan PC Picolinamides as effective ligands for copper-catalysed aryl ether formation: structure-activity relationships, substrate scope and mechanistic investigations Chemistry (Weinheim an der Bergstrasse, Germany) 20 17606-17615, 2014
DOI:10.1002/chem.201404275
View abstract

Breen JR, Blacker J, Gasparini G, Robinson S Continuous flow synthesis of chiral amines Abstracts of Papers of the American Chemical Society 248 , 2014
View abstract

Nova A, Taylor DJ, Blacker AJ, Duckett SB, Perutz RN, Eisenstein O Computational studies explain the importance of two different substituents on the chelating bis(amido) ligand for transfer hydrogenation by bifunctional Cp*Rh(III) catalysts Organometallics 33 3433-3442, 2014
DOI:10.1021/om500356e
View abstract

Sambiagio C, Marsden SP, Blacker AJ, McGowan PC Copper catalysed Ullmann type chemistry: from mechanistic aspects to modern development CHEMICAL SOCIETY REVIEWS 43 3525-3550, 2014
DOI:10.1039/c3cs60289c

Rodríguez-Bárzano A, Fonseca JDA, Blacker AJ, McGowan PC Ruthenium halide complexes as N-alkylation catalysts European Journal of Inorganic Chemistry 2014 1974-1983, 2014
DOI:10.1002/ejic.201400117
View abstract

Rodríguez-Bárzano A, Blacker AJ, McGowan PC Synthesis and characterisation of tetramethylfulvene complexes of ruthenium. Dalton Trans 42 16669-16671, 2013
DOI:10.1039/c3dt52747f
View abstract

Lucas SJ, Crossley BD, Pettman AJ, Vassileiou AD, Screen TEO, Blacker AJ, McGowan PC A robust method to heterogenise and recycle group 9 catalysts Chemical Communications 5562-5564, 2013
DOI:10.1039/c3cc42550a
View abstract

Winkworth PGA, Blacker J, Marsden SP, Telford A, Ford GJG Catalytic hydrogen transfer in polycyclic indole formation Abstracts of papers of the American Chemical Society 245 , 2013

Lucas SJ, McGowan PC, Blacker AJ Tethered [p]Cp* based[p]group 9 complexes as transfer hydrogenation catalysts ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 243 , 2012

Page PCB, Farah MM, Buckley BR, Elsegood MRJ, Blacker AJ Novel biphenyl organocatalysts for iminium ion-catalyzed asymmetric epoxidation Tetrahedron -, 2012
DOI:10.1016/j.tet.2012.10.076
View abstract

Blacker J, Williams MT Pharmaceutical Process Development, 2011
View abstract

Blaser HU, Federsel H-JR Asymmetric Catalysis on Industrial Scale, 2011
View abstract

Blacker AJ, Roy M, Hariharan S, Headley C, Upare A, Jagtap A, Wankhede K, Mishra SK, Dube D, Bhise S, Vishwasrao S, Kadam N Convenient Method for Synthesis of N-Protected alpha-Amino Epoxides: Key Intermediates for HIV Protease Inhibitors ORG PROCESS RES DEV 15 331-338, 2011
DOI:10.1021/op100174

Blacker AJ, Williams MT Pharmaceutical Process Development Current Chemical and Engineering Challenges Preface PHARMACEUTICAL PROCESS DEVELOPMENT: CURRENT CHEMICAL AND ENGINEERING CHALLENGES VII-VIII, 2011
DOI:10.1039/9781849733076-FP007

Blacker AJ, Williams MT Future Trends and Challenges PHARMACEUTICAL PROCESS DEVELOPMENT: CURRENT CHEMICAL AND ENGINEERING CHALLENGES 331-341, 2011
DOI:10.1039/9781849733076-00331

Blacker AJ, Williams MT Pharmaceutical Process Development Current Chemical and Engineering Challenges Introduction PHARMACEUTICAL PROCESS DEVELOPMENT: CURRENT CHEMICAL AND ENGINEERING CHALLENGES 1-14, 2011
DOI:10.1039/9781849733076-00001

Saidi O, Bamford MJ, Blacker AJ, Lyncha J, Marsden SP, Plucinski P, Watson RJ, Williams JMJ Iridium-catalyzed formylation of amines with paraformaldehyde Tetrahedron Letters 51 5804-5806, 2010
DOI:10.1016/j.tetlet.2010.08.106
View abstract

Blacker AJ, Roy M, Hariharan S, Upare A, Jagtap A, Wankhede K, Mishra SK, Dube D, Bhise S, Vishwasrao S, Kadam N Convenient Method for Synthesis of N-Protected alpha-Amino Epoxides: Key Intermediates for HIV Protease Inhibitors ORG PROCESS RES DEV 14 1364-1371, 2010
DOI:10.1021/op100174j

Saidi O, Blacker AJ, Lamb GW, Marsden SP, Taylor JE, Williams JMJ Borrowing Hydrogen in Water and Ionic Liquids: Iridium-Catalyzed Alkylation of Amines with Alcohols ORG PROCESS RES DEV 14 1046-1049, 2010
DOI:10.1021/op100024j

Blacker AJ, Thompson P Scale-Up Studies in Asymmetric Transfer Hydrogenation, 2010
DOI:10.1002/9783527630639.ch16

Dunn P, Wells A, Williams MT Green Chemistry in the Pharmaceutical Industry, 2010
View abstract

Blacker J, Headley CE Dynamic Resolution of Chiral Amine Pharmaceuticals: Turning Waste Isomers into Useful Product, 2010
DOI:10.1002/9783527629688.ch13

McConville M, Ruan JW, Blacker J, Xiao JL Synthesis of oxygen heterocycles by regioselective Heck reaction ORG BIOMOL CHEM 8 5614-5619, 2010
DOI:10.1039/c0ob00508h

Valera FE, Quaranta M, Moran A, Blacker J, Armstrong A, Cabral JT, Blackmond DG The Flow's the Thing ... Or Is It? Assessing the Merits of Homogeneous Reactions in Flask and Flow ANGEW CHEM INT EDIT 49 2478-2485, 2010
DOI:10.1002/anie.200906095

McConville M, Blacker J, Xiao JL Heck Reaction in Diols and Cascade Formation of Cyclic Ketals SYNTHESIS-STUTTGART 349-360, 2010
DOI:10.1055/s-0029-1217139

Saidi O, Blacker AJ, Farah MM, Marsden SP, Williams JMJ Iridium-catalysed amine alkylation with alcohols in water CHEM COMMUN 46 1541-1543, 2010
DOI:10.1039/b923083a

Fow KL, Zhu Y, Chuah GK, Jaenicke S, Van Nispen SFGM, Van Buijtenen J, Vekemans JAJM, Meuldijk J, Hulshof LA, Page M, Blacker J, Stirling M, Ko SB, Kim MJ, Park J, Gastaldi S, Gil G, Bertrand MP, Kamaruddin AH, Hamzah F, Kamaruddin AH, Hamzah F, Truppo M, Pollard D, Moore J, Devine P Dynamic Kinetic Resolution for the Synthesis of Esters, Amides and Acids Using Lipases, 2009
DOI:10.1002/9780470748589.ch4

Blacker AJ, Clot E, Duckett SB, Eisenstein O, Grace J, Nova A, Perutz RN, Taylor DJ, Whitwood AC Synthesis and structure of "16-electron" rhodium(III) catalysts fortransfer hydrogenation of a cyclic imine: mechanistic implications. Chem Commun (Camb) 6801-6803, 2009
DOI:10.1039/b912943j
View abstract

Blacker AJ, Farah MM, Marsden SP, Saidi O, Williams JMJ Oxidative conversion of amines into benzoxazoles using hydrogen transfer catalysis TETRAHEDRON LETT 50 6106-6109, 2009
DOI:10.1016/j.tetlet.2009.08.042

Blacker AJ, Brown S, Clique B, Gourlay B, Headley CE, Ingham S, Ritson D, Screen T, Stirling MJ, Taylor D, Thompson G A Low-Waste Process To Sertraline By Diastereomeric Crystal Resolution and Waste Isomer Racemisation ORG PROCESS RES DEV 13 1370-1378, 2009
DOI:10.1021/op900112f

Page PCB, Buckley BR, Farah MM, Blacker AJ Binaphthalene-Derived Iminium Salt Catalysts for Highly Enantioselective Asymmetric Epoxidation EUR J ORG CHEM 3413-3426, 2009
DOI:10.1002/ejoc.200900252

Blacker AJ, Farah MM, Hall MI, Marsden SP, Saidi O, Williams JMJ Synthesis of benzazoles by hydrogen-transfer catalysis. Org Lett 11 2039-2042, 2009
DOI:10.1021/ol900557u
View abstract

McConville M, Saidi O, Blacker J, Xiao JL Regioselective Heck Vinylation of Electron-Rich Olefins with Vinyl Halides: Is the Neutral Pathway in Operation? J ORG CHEM 74 2692-2698, 2009
DOI:10.1021/jo802781m

Blacker AJ, Duckett SB, Grace J, Perutz RN, Whitwood AC Reactivity, Structures, and NMR Spectroscopy of Half-Sandwich Pentamethylcyclopentadienyl Rhodium Amido Complexes Relevant to Transfer Hydrogenation ORGANOMETALLICS 28 1435-1446, 2009
DOI:10.1021/om8009969

Saidi O, Blacker AJ, Farah MM, Marsden SP, Williams JMJ Selective Amine Cross-Coupling Using Iridium-Catalyzed "Borrowing Hydrogen" Methodology ANGEW CHEM INT EDIT 48 7375-7378, 2009
DOI:10.1002/anie.200904028

Grigg R, Blacker J, Kilner C, McCaffrey S, Savic V, Sridharan V Stereoselective synthesis of chiral beta(2,3)-disubstituted-beta-amino acid derivatives using Pd/In transmetallation cascade processes TETRAHEDRON 64 8177-8181, 2008
DOI:10.1016/j.tet.2008.06.037

Page PCB, Farah MM, Buckley BR, Blacker AJ, Lacour J Novel binaphthalene-amine catalysts for the asymmetric epoxidation of alkenes SYNLETT 1381-1385, 2008
DOI:10.1055/s-2008-1072592

Ikariya T, Blacker AJ Asymmetric transfer hydrogenation of ketones with bifunctional transition metal-based molecular ACCOUNTS CHEM RES 40 1300-1308, 2007
DOI:10.1021/ar700134q

Page PCB, Buckley BR, Barros D, Blacker AJ, Marples BA, Elsegood MRJ Asymmetric organocatalysis of epoxidation by iminium salts under non-aqueous conditions TETRAHEDRON 63 5386-5393, 2007
DOI:10.1016/j.tet.2007.04.066

Blacker AJ, Stirling MJ, Page MI Catalytic racemisation of chiral amines and application in dynamic kinetic resolution ORG PROCESS RES DEV 11 642-648, 2007
DOI:10.1021/op060233w

Blacker AJ Enantioselective Transfer Hydrogenations In The Handbook of Homogeneous Hydrogenation , 2007

Stirling M, Blacker AJ, Page MI Chemoenzymatic dynamic kinetic resolution of secondary amines Tetrahedron Letters 48 1247-1250, 2007

Page PCB, Farah MM, Buckley BR, Blacker AJ New chiral binaphthalene-derived iminium salt organocatalysts for asymmetric epoxidation of alkenes The Journal of Organic Chemistry (Washington) 72 4424-4430, 2007

Vries JGD, Elsevier CJ The handbook of homogeneous hydrogenation, 2007

Grigg R, McCaffrey S, Sridharan V, Fishwick CWG, Kilner C, Korn S, Bailey K, Blacker J Enantioselective synthesis of non-proteinogenic 2-arylallyl-alpha-amino acids via Pd/In catalytic cascades TETRAHEDRON 62 12159-12171, 2006
DOI:10.1016/j.tet.2006.09.098

Belokon YN, Blacker AJ, Clutterbuck LA, Hogg D, North M, Reeve C An asymmetric, chemo-enzymatic synthesis of O-acetylcyonohydrins European Journal of Organic Chemistry 20 4609-4617, 2006

Page PCB, Buckley BR, Barros D, Blacker AJ, Heaney H, Marples BA Non-aqueous iminium salt mediated catalytic asymmetric epoxidation Tetrahedron 62 6607-6613, 2006

Li XH, Blacker J, Houson I, Wu XF, Xiao JL An efficient Ir(III) catalyst for the asymmetric transfer hydrogenation of ketones in neat water SYNLETT 1155-1160, 2006
DOI:10.1055/s-2006.932490

Page PCB, Buckley BR, Rassias GA, Blacker AJ New chiral iminium salt catalysis for asymmetric epoxidation European Journal of Organic Chemistry 30 803-813, 2006

Blacker J, North M Commercial catalysts CHEM IND-LONDON 22-25, 2005

Page PCB, Buckley BR, Heaney H, Blacker AJ asymmetric epoxidation of cis-alkenes mediated by iminium salts: Highly enantioselective synthesis of levcromakalim Organic Letters 7 375-377, 2005

Belokon YN, Blacker AJ, Carta P, Clutterbuck LA, North M Synthetic and mechanistic studies on asymmetric cyanohydrin synthesis using a titanium(salen) bimetallic catalyst Tetrahedron 60 10433-10447, 2004

Sun XY, Manos G, Blacker J, Martin J, Gavriilidis A Asymmetric transfer hydrogenation of acetophenone with 1R,2S-aminoindanol/pentamethylcyclopentadienylrhodiuim catalyst ORG PROCESS RES DEV 8 909-914, 2004
DOI:10.1021/op0499066

Blacker AJ, North M, Belokon YN Asymmetric carbon-carbon bond formation. Use of CACHy™ catalysts to produce optically active cyanohydrins Chimica Oggi 22 -, 2004
View abstract

Atherton JH, Blacker J, Crampton MR, Grosjean C The Strecker reaction: kinetic and equilibrium studies of cyanide addition to iminium ions. Org Biomol Chem 2 2567-2571, 2004
DOI:10.1039/B407853E
View abstract

Page PCB, Buckley BR, Blacker AJ Iminium salt catalysts for asymmetric epoxidation: The first high enantioselectivities Organic Letters 6 1543-1546, 2004

Belokon YN, Blacker AJ, Clutterbuck LA, North M Catalytic, asymmetric synthesis of cyanohydrin ethyl carbonates Organic Letters 5 4505-4507, 2003

Murphy DM, Boyd DR, Sharma ND, Blacker AJ Chemoenzymatic synthesis of chiral aza-arene ligands Abstracts of papers of the American Chemical Society 226 115-115, 2003

Murphy DM, Boyd FR, Sharma ND, Blacker AJ Chemoenzymatic synthesis of chiral aza-arene ligands Biochemistry 42 8601-8601, 2003

Lim CW, Tissot O, Mattison A, Hooper MW, Brown JM, Cowley AR, Hulmes DI, Blacker AJ Practical preparation and resolution of 1-(2 '-diphenylphosphino-1'-naphthyl)isoquinoline: A useful ligand for catalytic asymmetric synthesis Organic Process Research and Development 7 379-384, 2003

Boyd DR, Sharma ND, Kerley NA, McConville G, Allen CCR, Blacker AJ Chemoenzymatic synthesis of enantiopure dihydroxy-1,2,3,4-tetrahydronophthalenes from naphthalene and dihydronaphthalene precursors Arkivoc (Archive for Organic Chemistry) 7 32-48, 2003

Beagley P, Davies PJ, Blacker AJ, White C Chiral metallocenes. 3. The enantioselective reduction of C=X bonds (X = O or CH2) by the chiral ansa=metallocenes (R) - or (S) - [TiCl2(eta(5) :eta(5) - C5Me4SiMe2C5H3R*)] (R* = menthyl or neomenthyl) Organometallics 21 5852-5858, 2002

Aggarwal VK, Coogan MP, Stenson RA, Jones RVH, Fieldhouse R, Blacker J Developments in the simmons-smith-mediated epoxidation reaction European Journal of Organic Chemistry 319-326, 2002
View abstract

Bubert C, Blacker J, Brown SM, Crosby J, Fitzjohn S, Muxworthy JP, Thorpe T, Williams JMJ Synthesis of water-soluble aminosulfonamide ligands and their application in enantioselective transfer hydrogenation TETRAHEDRON LETT 42 4037-4039, 2001

Thorpe T, Blacker J, Brown SM, Bubert C, Crosby J, Fitzjohn S, Muxworthy JP, Williams JMJ Efficient rhodium and iridium-catalysed asymmetric transfer hydrogenation using water-soluble aminosulfonamide ligands TETRAHEDRON LETT 42 4041-4043, 2001

Tomkins JM, Nabbs BK, Barnes K, Legido M, Blacker AJ, McKendry RA, Abeil C Preparation of symmetrical and unsymmetrical DNA-protein conjugates with DNA as a molecular scaffold ChemBioChem 2 375-378, 2001

Aggarwal VK, Stenson RA, Jones RVH, Fieldhouse R, Blacker J A novel procedure for the synthesis of aziridines: application of Simmons-Smith reagents to aziridination TETRAHEDRON LETT 42 1587-1589, 2001

Blacker AJ Catalytic Asymmetric Synthesis, 2nd Ed. Edited by Iwao Ojima Wiley-VCH: New York. 2000. 864 pp. DM 298. ISBN 0-471-29805-0 Organic Process Research&Development 5 340-340, 2001

Blacker AJ Recent developments in chiral technology Innovations in Pharmaceutical Technology 01 77-81, 2001

Blacker AJ, Clarke ML, Loft MS, Mahon MF, Humphries ME, Williams JM Platinum-catalysed allylic alkylation: reactivity, enantioselectivity, and regioselectivity. Chemistry 6 353-360, 2000
DOI:10.1002/(SICI)1521-3765(20000117)6:2<353::AID-CHEM353>3.0.CO;2-U
View abstract

King EC, Blacker AJ, Bugg TDH Enzymatic breakdown of poly-gamma-D-glutamic acid in Bacillus licheniformis: Identification of a polyglutamyl gamma-hydrolase enzyme BIOMACROMOLECULES 1 75-83, 2000
DOI:10.1021/bm990001n

Blacker AJ, Clarke ML, Loft MS, Williams JMJ Use of tricyclohexylphosphine to control regiochemistry in palladium-catalyzed allylic alkylation ORG LETT 1 1969-1971, 1999

Blacker AJ, Clarke ML, Loft MS, Mahon MF, Williams JMJ Synthesis and structure of enantiomerically pure platinum complexes of phosphino-oxazolines and their use in asymmetric catalysis ORGANOMETALLICS 18 2867-2873, 1999

Bowers NI, Boyd DR, Sharma ND, Goodrich PA, Groocock MR, Blacker AJ, Goode P, Dalton H Stereoselective benzylic hydroxylation of 2-substituted indanes using toluene dioxygenase as biocatalyst J CHEM SOC PERK T 1 1453-1461, 1999

Blacker AJ, Clark ML, Loft MS, Williams JMJ First highly enantioselective allylic alkylations catalysed by platinum complexes CHEM COMMUN 913-914, 1999

King EC, Watkins WJ, Blacker AJ, Bugg TDH Covalent modification in aqueous solution of poly-gamma-D-glutamic acid from Bacillus licheniformis J POLYM SCI POL CHEM 36 1995-1999, 1998

Boyd DR, Sharma ND, Byrne B, Hand MV, Malone JF, Sheldrake GN, Blacker J, Dalton H Enzymatic and chemoenzymatic: synthesis and stereochemical assignment of cis-dihydrodiol derivatives of monosubstituted benzenes J CHEM SOC PERK T 1 1935-1943, 1998

Blacker AJ, Teulade-Fichou MP, Vigneron JP, Fauquet M, Lehn JM Selective photocleavage of single-stranded nucleic acids by cyclobisintercaland molecules. Bioorg Med Chem Lett 8 601-606, 1998
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Collins AN, Sheldrake GN, Crosby J Chirality in Industry II, 1998
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Knight FI, Brown JM, Lazzari D, Ricci A, Blacker AJ Electrophilic amination of catecholboronate esters formed in the asymmetric hydroboration of vinylarenes TETRAHEDRON 53 11411-11424, 1997

Tomkins JM, Barnes KJ, Blacker AJ, Watkins WJ, Abell C Lipophilic modification of oligonucleotides TETRAHEDRON LETT 38 691-694, 1997

Boyd DR, Sharma ND, Bowers NI, Goodrich PA, Groocock MR, Blacker AJ, Clarke DA, Howard T, Dalton H Stereoselective dioxygenase-catalysed benzylic hydroxylation at prochiral methylene groups in the chemoenzymatic synthesis of enantiopure vicinal aminoindanols. TETRAHEDRON-ASYMMETR 7 1559-1562, 1996

BLACKER AJ, BOOTH RJ, DAVIES GM, SUTHERLAND JK SYNTHESES OF 6-BETA-HYDROXYSHIKIMIC ACID AND ITS DERIVATIVES J CHEM SOC PERK T 1 2861-2870, 1995

PARKER MC, MOORE BD, BLACKER AJ MEASURING ENZYME HYDRATION IN NONPOLAR ORGANIC-SOLVENTS USING NMR BIOTECHNOL BIOENG 46 452-458, 1995

Blacker AJ Measuring enzyme hydration in nonpolar organic solvents using NMR Biotechnology and Bioengineering 46 452-458, 1995

Blacker AJ Scaling biological processes to make chiral fine chemicals Speciality Chemicals 15 S1-S4, 1995

BOYD DR, SHARMA ND, AGARWAL R, KERLEY NA, MCMORDIE RAS, SMITH A, DALTON H, BLACKER AJ, SHELDRAKE GN A NEW SYNTHETIC ROUTE TO NON-K AND BAY-REGION ARENE OXIDE METABOLITES FROM CIS-DIOLS J CHEM SOC CHEM COMM 1693-1694, 1994

Boyd DR, Blacker J, Byrne B, Dalton H, Hand MV, Kelly SC, Oferrall RAM, Rao SN, Sharma ND, Sheldrake GN Acid-catalyzed aromatization of benzene CIS-1,2-dihydrodiols - a carbocation transition-state poorly stabilized by resonance Journal of the Chemical Society, Chemical Communications 313-314, 1994
DOI:10.1039/C39940000313
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PARKER MC, MOORE BD, BLACKER AJ IN-SITU HYDRATION OF ENZYMES IN NONPOLAR ORGANIC MEDIA CAN INCREASE THE CATALYTIC RATE BIOCATALYSIS 10 269-277, 1994

Blacker AJ Plastics from Microbes In Plastics from Microbes , 1994

Blacker AJ Quantitative deuterium NMR of protein hydration in air and organic solvents Progress in Biotechnology 8 261-266, 1992
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Gaucheron F, Malinge JM, Blacker AJ, Lehn JM, Leng M Possible catalytic activity of DNA in the reaction between the antitumor drug cis-diamminedichloroplatinum(II) and the intercalator N-methyl-2,7-diazapyrenium Proceedings of the National Academy of Sciences of the United States of America 88 3516-3519, 1991
View abstract

Blacker AJ Oxidation reactions of aromatic compounds by biochemical routes Informations Chimie 333 182-183, 1991

Malinge JM, Sip M, Blacker AJ, Lehn JM, Leng M Formation of a DNA monofunctional cis-platinum adduct cross-linking the intercalating drug N-methyl-2, 7-diazapyrenium Nucleic Acids Research 18 3887-3891, 1990
DOI:10.1093/nar/18.13.3887
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Hosseini MW, Blacker AJ, Lehn JM Multiple molecular recognition and catalysis. A multifunctional anion receptor bearing an anion binding site, an intercalating group, and a catalytic site for nucleotide binding and hydrolysis Journal of the American Chemical Society 112 3896-3904, 1990
DOI:10.1021/ja00166a025
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HOSSEINI MW, BLACKER AJ, LEHN JM MULTIPLE MOLECULAR RECOGNITION AND CATALYSIS - NUCLEOTIDE BINDING AND ATP HYDROLYSIS BY A RECEPTOR MOLECULE BEARING AN ANION BINDING-SITE, AN INTERCALATOR GROUP, AND A CATALYTIC SITE J CHEM SOC CHEM COMM 596-598, 1988

Jazwinski J, Blacker AJ, Lehn JM, Cesario M, Guilhem J, Pascard C Cyclo-bisintercalands: Synthesis and structure of an intercalative inclusion complex, and anion binding properties Tetrahedron Letters 28 6060-, 1987
DOI:10.1016/S0040-4039(00)96863-1
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Blacker AJ Molecular anion binding and substrate photooxidation in visible light by 2,7-diazapyrenium cations Helvetica Chimica Acta 70 1-12, 1987
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Blacker AJ, Jazwinski J, Lehn JM, Wilhelm FX Photochemical cleavage of DNA by 2,7-diazapyrenium cations Journal of the Chemical Society, Chemical Communications 1035-1037, 1986
DOI:10.1039/C39860001035
View abstract

Chapman MR, Kwan MHT, King G, Jolley KE, Hussain M, Hussain S, Salama IE, González Nino C, Thompson LA, Bayana ME, Clayton A, Nguyen BN, Turner NJ, Kapur N, Blacker AJ A Simple and Versatile Laboratory Scale CSTR for Multiphasic Continuous-Flow Chemistry and Long Residence Times Organic Process Research&Development -,
DOI:10.1021/acs.oprd.7b00173
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Jolley KE, Nye W, González Niño C, Kapur N, Rabion A, Rossen K, Blacker AJ Highly Productive Continuous Flow Synthesis of Di- and Tripeptides in Water Organic Process Research&Development -,
DOI:10.1021/acs.oprd.7b00214
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Zhao Y, Blacker J, Marsden S Sustainable aromatics: Synthesis and hydrogenolysis of trisubstituted-1,3,5-triazines with lignin monomer compounds,