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Paul Beales

Associate Professor
Member of the Crystallisation and Directed Assembly group

Contact details

Room: 1.13
Tel: +44 (0)113 3439101
Email: P.A.Beales@leeds.ac.uk

Keywords

Biomolecular self-assembly
Membrane biophysics
Bionanotechnology
Biological soft matter
Nucleic acid amphiphiles
Bottom-up synthetic biology
Nanomedicine and Nanotoxicology

Photograph of Paul Beales

Research interests

Paul's research focuses on the biophysical properties of lipid membranes and the applications of membrane-based materials. His current work specifically addresses challenges across the field of nanomedicine. This work includes the use of nucleic acid amphiphiles in nanomaterial assembly, adhesion studies and targeted drug delivery. Paul is also interested in therapeutic encapsulation in lipid-based systems and the development of artificial cellular systems for fundamental studies on their interactions with drug delivery systems (relevant to intracellular transport) and nanoparticles (relevant to potential nanotoxicity).

Useful links

Beales group website   
   
   

Publications

Miles DE, Mitchell EA, Kapur N, Beales PA, Wilcox RK Peptide:glycosaminoglycan hybrid hydrogels as an injectable intervention for spinal disc degeneration Journal of Materials Chemistry B 4 3225-3231, 2016
DOI:10.1039/c6tb00121a
View abstract

Petrache AI, Machin DC, Williamson DJ, Webb ME, Beales PA Sortase-mediated labelling of lipid nanodiscs for cellular tracing Molecular BioSystems 12 1760-1763, 2016
DOI:10.1039/c6mb00126b
View abstract

Khan S, Li M, Muench SP, Jeuken LJC, Beales PA Durable proteo-hybrid vesicles for the extended functional lifetime of membrane proteins in bionanotechnology Chemical Communications 52 11020-11023, 2016
DOI:10.1039/c6cc04207d
View abstract

Leite NB, Aufderhorst-Roberts A, Palma MS, Connell SD, Neto JR, Beales PA PE and PS Lipids Synergistically Enhance Membrane Poration by a Peptide with Anticancer Properties Biophysical Journal 109 936-947, 2015
DOI:10.1016/j.bpj.2015.07.033
View abstract

Beales PA, Ciani B, Cleasby AJ Nature's lessons in design: nanomachines to scaffold, remodel and shape membrane compartments. Physical Chemistry Chemical Physics 17 15489-15507, 2015
DOI:10.1039/c5cp00480b
View abstract

Beales PA, Ciani B Chemical compartmentalisation by membranes: From biological mechanism to biomimetic applications Physical Chemistry Chemical Physics 17 15487-15488, 2015
DOI:10.1039/c5cp90089a

Gordon VD, Beales PA, Shearman GC, Zhao Z, Seddon JM, Poon WCK, Egelhaaf SU Solid-Like Domains in Mixed Lipid Bilayers. Effect of Membrane Lamellarity and Transition Pathway Advances in Planar Lipid Bilayers and Liposomes 20 137-154, 2014
DOI:10.1016/B978-0-12-418698-9.00005-8
View abstract

Beales PA, Vanderlick TK Application of nucleic acid-lipid conjugates for the programmable organisation of liposomal modules. Advances in Colloid and Interface Science 207 290-305, 2014
DOI:10.1016/j.cis.2013.12.009
View abstract

Goodchild SC, Sheynis T, Thompson R, Tipping KW, Xue WF, Ranson NA, Beales PA, Hewitt EW, Radford SE β2-Microglobulin amyloid fibril-induced membrane disruption is enhanced by endosomal lipids and acidic pH. PLoS One 9 e104492-, 2014
DOI:10.1371/journal.pone.0104492
View abstract

Geerts N, Schreck CF, Beales PA, Shigematsu H, O'Hern CS, Vanderlick TK Using DNA-driven assembled phospholipid nanodiscs as a scaffold for gold nanoparticle patterning. Langmuir 29 13089-13094, 2013
DOI:10.1021/la403091w
View abstract

Xu J, Vanderlick TK, Beales PA Lytic and non-lytic permeabilization of cardiolipin-containing lipid bilayers induced by cytochrome C. PLoS One 8 -, 2013
DOI:10.1371/journal.pone.0069492
View abstract

Churchman AH, Wallace R, Milne SJ, Brown AP, Brydson R, Beales PA Serum albumin enhances the membrane activity of ZnO nanoparticles. Chemical Communications 49 4172-4174, 2013
DOI:10.1039/c3cc37871c
View abstract

Bergstrom CL, Beales PA, Lv Y, Vanderlick TK, Groves JT Cytochrome c causes pore formation in cardiolipin-containing membranes. Proceedings of the National Academy of Sciences of USA 110 6269-6274, 2013
DOI:10.1073/pnas.1303819110
View abstract

Beales PA, Geerts N, Inampudi KK, Shigematsu H, Wilson CJ, Vanderlick TK Reversible assembly of stacked membrane nanodiscs with reduced dimensionality and variable periodicity. Journal of the American Chemical Society 135 3335-3338, 2013
DOI:10.1021/ja311561d
View abstract

Zhang S, Nelson A, Beales PA Freezing or wrapping: the role of particle size in the mechanism of nanoparticle-biomembrane interaction. Langmuir 28 12831-12837, 2012
DOI:10.1021/la301771b
View abstract

Nam J, Vanderlick TK, Beales PA Formation and dissolution of phospholipid domains with varying textures in hybrid lipo-polymersomes Soft Matter 8 3982-3988, 2012

Beales PA, Bergstrom CL, Geerts N, Groves JT, Vanderlick TK Single vesicle observations of the cardiolipin-cytochrome C interaction: induction of membrane morphology changes. Langmuir 27 6107-6115, 2011
DOI:10.1021/la104924c
View abstract

Nam J, Beales PA, Vanderlick TK Giant phospholipid/block copolymer hybrid vesicles: mixing behavior and domain formation. Langmuir 27 1-6, 2011
DOI:10.1021/la103428g
View abstract

Beales PA, Nam J, Vanderlick TK Specific adhesion between DNA-functionalized "Janus'' vesicles: size-limited clusters Soft Matter 7 1747-1755, 2011
DOI:10.1039/c0sm01055c
View abstract

Xu J, Beales PA, Vanderlick TK DNA mediated artificial cell functionalization in the microfluidic environment ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 240 -, 2010

Beales PA, Vanderlick TK Partitioning of membrane-anchored DNA between coexisting lipid phases Journal of Physical Chemistry B 113 13678-13686, 2009
DOI:10.1021/jp9006735
View abstract

Beales PA, Vanderlick TK DNA as membrane-bound ligand-receptor pairs: duplex stability is tuned by intermembrane forces Biophysical Journal 96 1554-1565, 2009
DOI:10.1016/j.bpj.2008.11.027
View abstract

Nam J, Beales PA, Vanderlick TK Adhesive and mechanical properties of multi-componen block copolymer/phospholipid vesicles assembled via DNA hybridization and receptor-ligand binding AIChE Annual Meeting, Conference Proceedings -, 2008

Nam J, Beales PA, Vanderlick TK Biomimetic membrane properties and the morphology of giant hybrid vesicles with phospholipid/block copolymer coexistence AIChE Annual Meeting, Conference Proceedings -, 2008

Beales PA, Vanderlick TK Specific binding of different vesicle populations by the hybridization of membrane-anchored DNA Journal of Physical Chemistry A 111 12372-12380, 2007
DOI:10.1021/jp075792z
View abstract

Gordon VD, Beales PA, Zhao Z, Blake C, MacKintosh FC, Olmsted PD, Cates ME, Egelhaaf SU, Poon WCK Lipid organization and the morphology of solid-like domains in phase-separating binary lipid membranes Journal of Physics: Condensed Matter 18 L415-L420, 2006
DOI:10.1088/0953-8984/18/32/L02
View abstract

Beales PA, Gordon VD, Zhao ZJ, Egelhaaf SU, Poon WCK Solid-like domains in fluid membranes, 2005
DOI:10.1088/0953-8984/17/45/020

Beales PA, Gordon VD, Zhao ZJ, Egelhaaf SU, Poon WCK Solid-like domains in fluid membranes Journal of Physics Condensed Matter 17 S3341-S3346, 2005
DOI:10.1088/0953-8984/17/45/020
View abstract

Poon WCK, Egelhaaf SU, Beales PA, Salonen A, Sawyer L Protein crystallization: scaling of charge and salt concentration in lysozyme solutions Journal of Physics: Condensed Matter 12 L569-L574, 2000
DOI:10.1088/0953-8984/12/35/103
View abstract