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Stefan Auer

Lecturer
Member of the Crystallisation and Directed Assembly group

Contact details

Room: 1.12
Tel: +44 (0)113 3438669
Email: S.Auer@leeds.ac.uk

Keywords

Computational biophysics
Soft matter physics
Statistical mechanics
Biomolecular self-assembly
Phase transitions
Nucleation

Photograph of Stefan Auer

Research interests

My research is focused on the application of theoretical computational tools developed in soft condensed matter physics to investigate the phase behaviour and transitions of complex systems of biomolecules. From a purely statistical mechanical point of view an ensemble of many peptides and proteins represents a new and important system which should lead to bridge our understanding of colloidal systems, polymers, and proteins. Examples of transitions that I investigated include colloidal crystallization and the aggregation of proteins into amyloid fibrils. My long term goal is to understand more generally the nucleation and regulation of normal and aberrant self-assembly in biological systems, and how we can functionalise them as nanomaterials.

Useful links

Research group pages   
Centre for Molecular Nanoscience    
   

Publications

Auer S Simple Model of the Effect of Solution Conditions on the Nucleation of Amyloid Fibrils. J Phys Chem B -, 2017
DOI:10.1021/acs.jpcb.7b05400
View abstract

Rizzi LG, Auer S, Head DA Importance of non-affine viscoelastic response in disordered fibre networks Soft Matter 12 4332-4338, 2016
DOI:10.1039/c6sm00139d
View abstract

Rizzi LG, Auer S Amyloid Fibril Solubility Journal of Physical Chemistry B 119 14631-14636, 2015
DOI:10.1021/acs.jpcb.5b09210
View abstract

Auer S Nucleation of polymorphic amyloid fibrils Biophysical Journal 108 1176-1186, 2015
DOI:10.1016/j.bpj.2015.01.013
View abstract

Rizzi LG, Head DA, Auer S Universality in the morphology and mechanics of coarsening amyloid fibril networks Physical Review Letters 114 -, 2015
DOI:10.1103/PhysRevLett.114.078102
View abstract

Auer S Amyloid fibril nucleation: effect of amino acid hydrophobicity Journal of Physical Chemistry B 118 5289-5299, 2014
DOI:10.1021/jp411370y
View abstract

Bingham RJ, Rizzi LG, Cabriolu R, Auer S Communication: Non-monotonic supersaturation dependence of the nucleus size of crystals with anisotropically interacting molecules. Journal of Chemical Physics 139 -, 2013
DOI:10.1063/1.4861044
View abstract

Kashchiev D, Cabriolu R, Auer S Confounding the paradigm: Peculiarities of amyloid fibril nucleation Journal of the American Chemical Society 135 1531-1539, 2013
DOI:10.1021/ja311228d
View abstract

Cabriolu R, Kashchiev D, Auer S Breakdown of nucleation theory for crystals with strongly anisotropic interactions between molecules. J Chem Phys 137 204903-, 2012
DOI:10.1063/1.4767531
View abstract

Auer S, Ricchiuto P, Kashchiev D Two-step nucleation of amyloid fibrils: omnipresent or not? J Mol Biol 422 723-730, 2012
DOI:10.1016/j.jmb.2012.06.022
View abstract

Auer S, Ricchiuto P, Kashchiev D Two-step nucleation of amyloid fibrils: Omnipresent or not? Journal of Molecular Biology 422 723-730, 2012
DOI:10.1016/j.jmb.2012.06.022
View abstract

Brukhno AV, Ricchiuto P, Auer S Tracking polypeptide folds on the free energy surface: effects of the chain length and sequence. J Phys Chem B 116 8703-8713, 2012
DOI:10.1021/jp300990k
View abstract

Ricchiuto P, Brukhno AV, Auer S Protein aggregation: kinetics versus thermodynamics. J Phys Chem B 116 5384-5390, 2012
DOI:10.1021/jp302797c
View abstract

Auer S Phase diagram of polypeptide chains. J Chem Phys 135 175103-, 2011
DOI:10.1063/1.3656764
View abstract

Cabriolu R, Kashchiev D, Auer S Size distribution of amyloid nanofibrils. Biophys J 101 2232-2241, 2011
DOI:10.1016/j.bpj.2011.09.053
View abstract

Ricchiuto P, Brukhno AV, Paci E, Auer S Communication: Conformation state diagram of polypeptides: a chain length inducedα-β transition. J Chem Phys 135 061101-, 2011
DOI:10.1063/1.3624928
View abstract

Cabriolu R, Auer S Amyloid Fibrillation Kinetics: Insight from Atomistic Nucleation Theory J MOL BIOL 411 275-285, 2011
DOI:10.1016/j.jmb.2011.05.032

Brukhno AV, Akinshina A, Coldrick Z, Nelson A, Auer S Phase phenomena in supported lipid films under varying electric potential SOFT MATTER 7 1006-1017, 2011
DOI:10.1039/c0sm00724b

Cabriolu R, Kashchiev D, Auer S Atomistic theory of amyloid fibril nucleation. J Chem Phys 133 225101-, 2010
DOI:10.1063/1.3512642
View abstract

Auer S, Kashchiev D Insight into the correlation between lag time and aggregation rate in the kinetics of protein aggregation. Proteins 78 2412-2416, 2010
DOI:10.1002/prot.22762
View abstract

Kashchiev D, Auer S Nucleation of amyloid fibrils. J Chem Phys 132 215101-, 2010
DOI:10.1063/1.3447891
View abstract

Auer S, Kashchiev D Phase Diagram of alpha-Helical and beta-Sheet Forming Peptides PHYS REV LETT 104 -, 2010
DOI:10.1103/PhysRevLett.104.168105

Auer S, Trovato A, Vendruscolo M A condensation-ordering mechanism in nanoparticle-catalyzed peptide aggregation. PLoS Comput Biol 5 e1000458-, 2009
DOI:10.1371/journal.pcbi.1000458
View abstract

Auer S, Dobson CM, Vendruscolo M, Maritan A Self-Templated Nucleation in Peptide and Protein Aggregation PHYS REV LETT 101 -, 2008
DOI:10.1103/PhysRevLett.101.258101

Auer S, Meersman F, Dobson CM, Vendruscolo M A Generic Mechanism of Emergence of Amyloid Protofilaments from Disordered Oligomeric Aggregates PLOS COMPUT BIOL 4 -, 2008
DOI:10.1371/journal.pcbi.1000222

Auer S, Miller MA, Krivov SV, Dobson CM, Karplus M, Vendruscolo M Importance of metastable states in the free energy landscapes of polypeptide chains Physical Review Letters 99 -, 2007
DOI:10.1103/PhysRevLett.99.178104
View abstract

Auer S, Dobson CM, Vendruscolo M Characterization of the nucleation barriers for protein aggregation and amyloid formation HFSP J 1 137-146, 2007
DOI:10.2976/1.2760023

Cacciuto A, Auer S, Frenkel D Onset of heterogeneous crystal nucleation in colloidal suspensions Nature 428 404-406, 2004
DOI:10.1038/nature02397

Auer S, Frenkel D Line tension controls wall-induced crystal nucleation in hard-sphere colloids Physical Review Letters 91 015703,1-4, 2003
DOI:10.1103/PhysRevLett.91.015703

Auer S, Frenkel D Suppression of crystal nucleation in polydisperse colloids due to increase of the surface free energy Nature 413 711-713, 2001
DOI:10.1038/35099513

Auer S, Frenkel D Prediction of absolute crystal-nucleation rate in hard-sphere colloids Nature 409 1020-1023, 2001
DOI:10.1038/35059035