School of Chemistry

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Richard Ansell

Senior Lecturer
Member of the Crystallisation and Directed Assembly group

Contact details

Room: 2.91a
Tel: +44 (0)113 3436415
Email: R.J.Ansell@leeds.ac.uk

Keywords

Chemical sensors
Molecular recognition
Nanostructured materials
Molecularly imprinted polymers
Templated materials
Modified electrodes and photoelectrodes
Electroorganic synthesis

Photograph of Richard Ansell

Research interests

My main interest is in new advanced materials and their applications in analytical science and electrochemistry. The work is multidisciplinary, at the boundaries of physical organic chemistry, biophysical chemistry, materials chemistry and analytical science.

Projects are in several areas

  1. Molecular recognition in imprinted polymers: Improving molecular recognition in these synthetic receptors through understanding and manipulating the interactions of the ligand with the binding site.
  2. Electrochemical biosensors: The interactions of NAD(P)(H) mimetics with dehydrogenases, electrochemical mediators and molecular wires, and their use in sensors.
  3. Nanostructured materials and surfaces: Using organic structures as templates to grow nanostructured inorganic films, tubes and particles.
  4. Electroorganic chemistry in flow devices.
  5. Modified electrodes for electroorganic synthesis, and photoelectrochemistry.

Useful links

Ansell lab web pages   
   
   

Publications

Ansell RJ Characterization of the Binding Properties of Molecularly Imprinted Polymers In Molecularly Imprinted Polymers in Biotechnology , 2015
DOI:10.1007/10_2015_316
View abstract

Cookson NJ, Henkelis JJ, Ansell RJ, Fishwick CW, Hardie MJ, Fisher J Encapsulation of sodium alkyl sulfates by the cyclotriveratrylene-based, [Pd(6)L(8)](12+) stella octangula cage. Dalton Trans 43 5657-5661, 2014
DOI:10.1039/c4dt00237g
View abstract

Brailsford AD, Gavrilović I, Ansell RJ, Cowan DA, Kicman AT Two-dimensional gas chromatography with heart-cutting for isotope ratio mass spectrometry analysis of steroids in doping control Drug Testing and Analysis 4 962-969, 2012
DOI:10.1002/dta.1379
View abstract

Ansell RJ, Kuah JKL, Wang D, Jackson CE, Bartle KD, Clifford AA Imprinted polymers for chiral resolution of (±)-ephedrine, 4: Packed column supercritical fluid chromatography using molecularly imprinted chiral stationary phases Journal of Chromatography A 1264 117-123, 2012
DOI:10.1016/j.chroma.2012.09.069
View abstract

Nguyen TH, Ansell RJ N-isopropylacrylamide as a functional monomer for noncovalent molecular imprinting JOURNAL OF MOLECULAR RECOGNITION 25 1-10, 2012
DOI:10.1002/jmr.1163

Brailsford AD, Gavrilović I, Cowan DA, Kicman AT, Ansell RJ Two-dimensional gas chromatography with heart-cutting for isotope ratio mass spectrometry analysis of steroids in doping control Drug Testing and Analysis -, 2012
DOI:10.1002/dta.1379
View abstract

Ansell RJ, Kuah JKL, Wang D, Jackson CE, Bartle KD, Clifford AA Imprinted polymers for chiral resolution of (±)-ephedrine, 4: Packed column supercritical fluid chromatography using molecularly imprinted chiral stationary phases Journal of Chromatography A -, 2012
DOI:10.1016/j.chroma.2012.09.069
View abstract

Gavrilovic I, Mitchell K, Brailsford AD, Cowan DA, Kicman AT, Ansell RJ A molecularly imprinted receptor for separation of testosterone and epitestosterone, based on a steroidal cross-linker STEROIDS 76 478-483, 2011
DOI:10.1016/j.steroids.2011.01.004

Nguyen TH, Ansell RJ Fluorescent imprinted polymer sensors for chiral amines. Org Biomol Chem 7 1211-1220, 2009
DOI:10.1039/b816733h
View abstract

Ansell RJ, Wang D Imprinted polymers for chiral resolution of (+/-)-ephedrine. Part 3: NMR predictions and HPLC results with alternative functional monomers. Analyst 134 564-576, 2009
DOI:10.1039/b815145h
View abstract

Ansell RJ, Meegan JE, Barrett SA, Warrinner SL On the interactions of alkyl 2-hydroxycarboxylic acids with alkoxysilanes 2. Complexation and esterification of di- and tricarboxylic acids DALTON T 1460-1470, 2009
DOI:10.1039/b814488e

Ansell RJ, Tunon PG, Wang YT, Myers P, Ivory CF, Keen JN, Findlay JBC Electrophoretic field gradient focusing with on-column detection by fluorescence quenching ANALYST 134 226-229, 2009
DOI:10.1039/b815446e

Tunon PG, Wang Y, Myers P, Bartle KD, Bowhill L, Ivory CF, Ansell RJ Electrophoretic field gradient focusing: An investigation of the experimental parameters ELECTROPHORESIS 29 457-465, 2008
DOI:10.1002/elps.200700443

Ansell RJ, Wang DY, Kuah JKL Imprinted polymers for chiral resolution of (+/-)-ephedrine. Part 2: probing pre-polymerisation equilibria in different solvents by NMR ANALYST 133 1673-1683, 2008
DOI:10.1039/b806376a

Ansell RJ, Barrett SA, Meegan JE, Warriner SL On the interactions of alkyl 2-hydroxycarboxylic acids with alkoxysilanes: Selective esterification of simple 2-hydroxycarboxylic acids Chemistry a European journal 13 4654-4664, 2007
DOI:10.1002/chem.200601859

Hunt CE, Ansell RJ Use of fluorescence shift and fluorescence anisotropy to evaluate the re-binding of template to (S)-propranolol imprinted polymers. Analyst 131 678-683, 2006
DOI:10.1039/b518248d
View abstract

Alexander C, Andersson HS, Andersson LI, Ansell RJ, Kirsch N, Nicholls IA, O'Mahony J, Whitcombe MJ Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003 Journal of Molecular Recognition 19 106-180, 2006

Hunt CE, Pasetto P, Ansell RJ, Haupt K A fluorescence polarisation molecular imprint sorbent assay for 2,4-D: a non-separation pseudo-immunoassay Chemical Communications 16 1754-1756, 2006
DOI:10.1039/b516194k

Ansell RJ Molecularly imprinted polymers for the enantioseparation of chiral drugs ADV DRUG DELIVER REV 57 1809-1835, 2005
DOI:10.1016/j.addr.2005.07.014

Meegan JE, Aggeli A, Ansell RJ, Brown A, Brydson R An SEM study of the effect of altering the reaction pH on fluoride catalysed silica sol-gel templating of self-assembling peptide fibrils Materials Research Society Symposium Proceedings 897 93-100, 2005

Ansell RJ Application of MIPs as Antibody Mimics in Immunoassays In Molecularly Imprinted Materials, Science&Technology , 2005

Ansell RJ, Kuah KL Imprinted polymers for chiral resolution of (+/-)-ephedrine: understanding the pre-polymerisation equilibrium and the action of different mobile phase modifiers The Analyst 130 179-187, 2004
DOI:10.1039/b408751h

Ansell RJ Molecularly imprinted polymers in pseudoimmunoassay. J Chromatogr B Analyt Technol Biomed Life Sci 804 151-165, 2004
DOI:10.1016/j.jchromb.2004.02.022
View abstract

Meegan JE, Aggeli A, Boden N, Brydson R, Brown AP, Carrick L, Ansell RJ EFTEM investigation of silica nanotubes produced using designed self assembling beta-sheet peptide fibrils as templates INST PHYS CONF SER , 2004
View abstract

Meegan JE, Aggeli A, Boden N, Brydson R, Brown AP, Carrick L, Brough AR, Hussain A, Ansell RJ Designed self-assembled beta-sheet peptide fibrils as templates for silica nanotubes ADV FUNCT MATER 14 31-37, 2004
DOI:10.1002/adfm.200304477

Brydson RMD, Brown AP, Pan S, Lovely GR, Aslam Z, Calvert C, Meegan JE, Scott AJ, Ansell RJ Electron energy loss spectroscopy of physical and biological nanostructured materials Beijing Conference Conference on Analysis and Instrumentation, Beijing, China , 2003

Kriz D, Ansell RJ Biomimetic electrochemical sensors based on molecular imprinting In Techniques and Instrumentation in Analytical Chemistry , 2001

Ansell RJ MIP-ligand binding assays (pseudo-immunoassays) BIOSEPARATION 10 365-377, 2001

Ansell RJ, Mosbach K Magnetic molecularity imprinted polymer beads for drug radioligand binding assay The Analyst 123 1611-1616, 1998

Ansell RJ, Mosbach K Molecularly imprinted polymers prepared by suspension polymerisation in perfluorocarbon liquids, with emphasis on the role of the porogenic solvent Journal of Chromatography 787 55-66, 1997

Ansell RJ, Kriz D, Mosbach K Molecularly imprinted polymers for bioanalysis: Chromatography, binding assays and biomimetic sensors Current Opinion in Biotechnology 7 89-94, 1996

Ansell RJ, Ramstrom O, Mosbach K Towards artificial antibodies by the technique of molecular imprinting Clinical Chemistry 42 1506-1512, 1996